公开(公告)号：JP2002308863A

公开(公告)日：2002-10-23

申请号：JP2001110778

申请日：2001-04-10

申请人： DAICEL CHEM

发明人： TANAKA HIROMI ,  HAN RITSUZUI ,  IKURA SEI

IPC分类号： C07B61/00 ,  C07D307/33

摘要： PROBLEM TO BE SOLVED: To provide a new 3-acetyl-N-substituted-3- aminomethyltetrahydrofuran-2-one derivative and its production method. SOLUTION: This derivative is represented by formula (1) (wherein R , R , and R are each H or an aliphatic hydrocarbon group; and R and R are each H or an optionally substituted arylmethyl group provided at least one on them is an optionally substituted arylmethyl group) and can be produced by the aminomethylation of a 3-acetyltetrahydrofuran-2-one derivative represented by formula (2) (wherein R , R , and R are each the same as described above) with a primary or secondary amine represented by formula (3) (wherein R and R are each the same as described above) and formaldehyde or its polymer.

公开(公告)号：JPH0741462A

公开(公告)日：1995-02-10

申请号：JP18590393

申请日：1993-07-28

申请人： DAICEL CHEM

发明人： MATSUOKA KAZUYUKI ,  HAN RITSUZUI

IPC分类号： B01J27/19 ,  B01J27/199 ,  C07B61/00 ,  C07C319/20 ,  C07C323/52

摘要： PURPOSE:To efficiently obtain 2-hydroxymethylmercaptobutyric acid at a low cost without producing a large amount of wastes. CONSTITUTION:This method for producing 2-hydroxymethylmercaptobutyric acid is to bring 2-hydroxymethylmercaptobutyramide in liquid phase into contact with water in the presence of a heteropolyacid or its salts and hydrolyze the 2-hydroxymethylmercaptobutyramide. Since sulfuric acid is not used as a reactional component, a large amount of ammonium sulfate is not discharged. Ammonia formed as a by-product can be circulated for use as a reactional raw material.

公开(公告)号：JPH10114703A

公开(公告)日：1998-05-06

申请号：JP27257396

申请日：1996-10-15

申请人： DAICEL CHEM

发明人： KAWABE MASATO ,  HAN RITSUZUI

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C51/145 ,  C07C57/04 ,  C07C67/38 ,  C07C69/533 ,  C07C69/54

摘要： PROBLEM TO BE SOLVED: To carry out carbonylation of an acetylene-type or allene-type unsaturated compound while stably keeping high conversion over a 1.ong period by reacting the unsaturated compound with carbon monoxide in the presence of a specific catal-ysl:: while keeping the conversion of the unsaturated corrpound within a specific range. SOLUTION: A carbonylation catalyst is produced e.g. by compounding l mol of a group Vlll metal source (e.g. tetrakistriphenylphosphineplatinum), 2-100 mol of a ligand (e.jg. triphenylphosphine) and 2-400 mol of an acid (e.g. methacrylic acid). An acetylene-type or allene-type unsaturated compound (e.g. propyne) is carbonylated with carbon monoxide at 10-250'C under atmospheric pressure to 150 atm in the presence of the catalyst while keeping the conversion of the unsaturated compound to ?9O%, preferdly S95%.

公开(公告)号：JPH06135886A

公开(公告)日：1994-05-17

申请号：JP31646892

申请日：1992-10-30

申请人： DAICEL CHEM

发明人： NAKANO TATSUYA ,  HAN RITSUZUI

IPC分类号： C07B61/00 ,  C07C51/12 ,  C07C51/14 ,  C07C51/48 ,  C07C53/124

摘要： PURPOSE:To efficiently obtain a highly pure carboxylic acid from the product of Koch reaction using sulfuric acid catalyst. CONSTITUTION:An olefin such as propene or an alcohol such as 2-propanol is reacted with carbon monoxide in the presence of sulfuric acid catalyst, and a carboxylic acid such as isobutyric acid is extracted with a solvent such as decane having a solubility parameter of from the mixture containing the sulfuric acid and the produced carboxylic acid. The carboxylic acid can also be obtained by extracting the mixed solution with a solvent having a higher boiling point than that of the carboxylic acid and subsequently distilling the extract solution. The carboxylic acid can further be recovered by extracting the mixture with an organic solvent and subsequently treating the extract solution with a weakly basic anion exchange resin.

公开(公告)号：JP2002322136A

公开(公告)日：2002-11-08

申请号：JP2001124499

申请日：2001-04-23

申请人： DAICEL CHEM

发明人： TANAKA HIROMI ,  HAN RITSUZUI ,  IKURA SEI

IPC分类号： C07C221/00 ,  C07B61/00 ,  C07C213/00 ,  C07C215/20 ,  C07C225/06 ,  C07C225/10

摘要： PROBLEM TO BE SOLVED: To provide a new N-substituted aminomethyl cyclopropyl ketone derivative or its salt which are usable for obtaining an aminomethyl cyclopropyl ketone derivative, a 2-amino-1-cyclopropyl ethanol derivative or their salts. SOLUTION: The N-substituted aminomethyl cyclopropyl ketone derivative and its hydrohalide salt are represented by general formula (1). [wherein, R , R , and R are each independently H or an aliphatic hydrocarbon group; R and R are each independently H or an arylmethyl group which may have a substituent, C at the methyl position of the arylmethyl group combins with at least a H atom or a substitutable arylmethyl group, at least one of R and R is an arylmethyl group which may have a substituent].

公开(公告)号：JPH09328448A

公开(公告)日：1997-12-22

申请号：JP14543996

申请日：1996-06-07

申请人： DAICEL CHEM

发明人： KAWABE MASATO ,  YAMAMOTO KENICHI ,  HAN RITSUZUI

IPC分类号： B01J31/04 ,  C07B41/08 ,  C07B61/00 ,  C07C51/06 ,  C07C53/122 ,  C07C59/08 ,  C07C319/12 ,  C07C323/52

摘要： PROBLEM TO BE SOLVED: To obtain a carboxylic acid useful as a basic raw material for organic compounds, by hydrolyzing a carboxylic acid amide in the presence of a carboxylic acid having specific acid strength. SOLUTION: A carboxylic acid amide is hydrolyzed in the presence of a carboxylic acid having

公开(公告)号：JPH0975744A

公开(公告)日：1997-03-25

申请号：JP25691295

申请日：1995-09-07

申请人： DAICEL CHEM

发明人： HAN RITSUZUI ,  MATSUOKA KAZUYUKI

IPC分类号： B01J31/28 ,  C07B61/00 ,  C07C67/38 ,  C07C69/54

摘要： PROBLEM TO BE SOLVED: To obtain a catalyst having high stability and catalytic activity and capable of maintaining high catalytic activity in a carbonylation reaction over a long period of time by combining oligomer or polymer type org. phosphine represented by a specified formula with a source of a group VIII metal of the Periodic Table and an acid. SOLUTION: This carbonylation catalyst system consists of a source of a group VIII metal of the Periodic Table, a polymer having units represented by the formula and an acid. In the formula, A is divalent hydrocarbon which may have a substituent, each of R1 and R2 is H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl or a heterocyclic group and may have a substituent and R1 and R2 may form alkylene by bonding to each other. The group VIII metal is Co, Ni, Rh or Pd and the acid is a protonic acid such as arylsulfonic acid or hydrohalogenic acid. This catalyst is fit for use in carbonylation of α-acetylene or an α-olefin compd.

公开(公告)号：JP2003113142A

公开(公告)日：2003-04-18

申请号：JP2001305917

申请日：2001-10-02

申请人： DAICEL CHEM

发明人： TANAKA HIROMI ,  HAN RITSUZUI ,  IKURA SEI

IPC分类号： C07C67/343 ,  C07C69/743

摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently and inexpensively producing an 1-acyl-1-cyclopropanecarboxylic ester derivative useful as a pharmaceutical intermediate. SOLUTION: This method for producing the 1-acyl-1-cyclopropanecarboxylic ester derivative of formula (2) (where, R is H or a hydrocarbon group; and R is a hydrocarbon group) comprises reacting the corresponding β-ketoester derivative of formula (1) (where, R and R are the same as mentioned above) with 1,2-dichloroethane.

公开(公告)号：JPH10114698A

公开(公告)日：1998-05-06

申请号：JP27257496

申请日：1996-10-15

申请人： DAICEL CHEM

发明人： KAWABE MASATO ,  HAN RITSUZUI

IPC分类号： B01J31/24 ,  C07B61/00 ,  C07C51/14 ,  C07C51/56 ,  C07C67/38 ,  C07C69/533 ,  C07C69/54

摘要： PROBLEM TO BE SOLVED: To keep the catalytic activity over a long period and suppress the formation of by-products by reacting an acetylenic or olefinic unsaturated compound with carbon monoxide having low hydrogen content ion the presence of a carbonylation catalyst. SOLUTION: An acetylenically or olefinically unsaturated compound (preferably a 2-10C α-acetylenically or α-olefinically unsaturated compound) is carbonylated by reacting with carbon monoxide in the presence of a carbonylation catalyst. The reaction is carried out by using carbon monoxide having a hydrogen content of to 1×10 mol in terms of metallic atom and that of carbon monoxide is 1-5mol based on 1mol of the unsaturated compound.

公开(公告)号：JPH08299803A

公开(公告)日：1996-11-19

申请号：JP22716695

申请日：1995-08-11

申请人： DAICEL CHEM

发明人： HAN RITSUZUI ,  MATSUOKA KAZUYUKI

IPC分类号： B01J31/28 ,  C07B61/00 ,  C07C67/38 ,  C07C69/54

摘要： PURPOSE: To carbonylate an acetylenic or olefinic unsaturated compd. by using a catalyst system having high stability and capable of keeping high catalytic activity over a long period of time. CONSTITUTION: A carbonylation catalyst system is constituted by containing a group VIII metal source (e.g. palladium, palladium chloride or the like), a ligand such as triphenylphosphine and an acid such as an alkylsulfonic acid supported on a carrier. An acetylenic or olefin unsaturated compd. and carbon monoxide are reacted in a liquid phase in the presence of the catalyst system and a carbonylated product is stably produced over a long period of time in a high conversion rate with high selectivity. Further, when a nuclephilic compd. having a separable hydrogen atom such as water, alcohol or carboxylic acid is reacted, an unsaturated or a saturated carboxylic acid or ester thereof is produced.