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公开(公告)号:JPH02268649A
公开(公告)日:1990-11-02
申请号:JP8868789
申请日:1989-04-08
申请人: KANEBO LTD
发明人: KIZAWA KENJI , NAGANUMA KEIKO , MURAKAMI UMEJI , TAKEMOTO TAIRA , FUKUDA MASAYOSHI , UCHIUMI KENJI , IGUCHI KEIJI
IPC分类号: A23G3/00 , A23G3/34 , A23G4/00 , A23J3/10 , A23J3/34 , A23L1/305 , A23L2/38 , A23L33/00 , C12P21/06
摘要: PURPOSE:To obtain a peptide mixture or its salt which is useful as a functional food or health food by hydrolyzing milk casein with pepsin, fractionating the hydrolysate and selecting the fraction. of specific solubility and molecular weight, having sedative action. CONSTITUTION:(A) Milk casein and (B) pepsin are added to (C) hydrochloric acid to effect hydrolysis, the reaction mixture is adjusted in its pH to 9 and combined with (D) ethanol to precipitate the subject peptide. The peptide mixture or its salt has more than 100mg/ml solubility in water, more than 1mg/ml solubility in ammonia 80% ethanol of pH9, 850 to 56,000 molecular weight, having physical condition-controlling functions.
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公开(公告)号:JPS62270533A
公开(公告)日:1987-11-24
申请号:JP11567486
申请日:1986-05-20
发明人: MARUYAMA SUSUMU , TOMIZUKA NOBORU , SUZUKI HIDEO , MORITA KAZUYOSHI , SUGAI RYUJI , TAKEMOTO TAIRA
IPC分类号: A61K38/17 , A23J3/10 , A23J3/34 , A23L1/305 , A23L2/66 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C12P21/06
摘要: PURPOSE:An ingestible substance, obtained by containing an angiotensin converting enzyme inhibitory peptide and useful as a health food for preventing hypertension, etc. CONSTITUTION:A peroral ingestible substance obtained by containing 5-60wt% angiotensin converting enzyme inhibitory peptide, e.g. CEI12 (having the amino acid sequence expressed by formula I), CEIbeta7 (formula II), CEI5 (formula III), etc., obtained by digesting casein with trypsin. The substance, together with a carrier, may be formulated into the form of tablet, capsule, powder, granule, etc. The substance may be used as a solid or liquid food, e.g. confectionery, powdered green tea, etc., or favorite food, e.g. alcohol beverage, sports drink, etc. In both cases, the substance is preferably enteric from the viewpoint of preventing hydrolysis of ACE inhibitory peptide and deterioration in activity by gastric fluid. EFFECT:The substance has extremely low toxicity and can be continuously and orally administered for aiming at moderation of hypertension tendency and regulation of blood pressure.
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公开(公告)号:JPS6178716A
公开(公告)日:1986-04-22
申请号:JP20285284
申请日:1984-09-26
申请人: Kanebo Ltd
发明人: KASHIKI HIROAKI , IDA ETSUKO , TAKEMOTO TAIRA , NAKAO KAZUO , INUI MASAYOSHI
摘要: PURPOSE: To provide a perfumery composition containing the essential oil component accumulated in the cultured cell or cultured tissue of a plant belonging to Pelargonium genus or Viola genus, and exhibiting remarkable effect when added to cosmetics, foods, etc.
CONSTITUTION: The leaf or leaf of a plant belonging to Pelargonium genus is cultured in a medium containing 10
-5 W10
-7 M of auxin and 10
-5 W10
-6 M of cytokinin, or the leaf or root of a plant belonging to Viola genus is cultured in a medium containing 10
-5 W10
-7 M of auxin and 10
-5 W10
-6 M of cytokinin. The cultivation is started by repeating the irradiation with light at 5,000W10,000 lux for 16W24hr and the keeping of the system in dark place for 8W0hr, and carried out at 22W30°C. The essential oil component accumulated in the induced callus, indefinite bud is separated e.g. by extraction with petroelum ether, steam distillation, etc. A cosmetic compounded with said essential oil component has low irritation to the skin and gives smoothly finished skin.
COPYRIGHT: (C)1986,JPO&Japio摘要翻译: 目的:提供含有在属于天竺葵属或中提琴属植物的培养细胞或培养组织中积聚的精油成分的香料组合物,并且在添加到化妆品,食品等中时显示出显着的效果。构成:叶或叶 的属于天竺葵属的植物在含有10 -5 -10 -7 M的生长素和10 -5 -5 -10 -6 M的细胞分裂素的培养基中培养,或者将叶或根 属于中堇属植物的植物在含有10 -5 -10 -7 M的生长素和10 -5 -5 -10 -6 M的细胞分裂素的培养基中培养。 通过以5,000-10,000勒克斯光重复照射16-24小时并在黑暗处保持该系统8-0小时,并在22-30℃进行培养开始培养。 积累在诱导愈伤组织中的精油成分,不定芽被分离,例如 通过用石油醚提取,蒸汽蒸馏等。与所述精油成分混合的化妆品对皮肤具有低刺激性并且给出平滑的成品皮肤。
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公开(公告)号:JPS613331B2
公开(公告)日:1986-01-31
申请号:JP13793882
申请日:1982-08-10
申请人: Kanebo Ltd
发明人: ARAI SEIICHI , TAKEMOTO TAIRA , ABE TAKASHI
IPC分类号: A61K49/00
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公开(公告)号:JPS60177026A
公开(公告)日:1985-09-11
申请号:JP3126984
申请日:1984-02-20
申请人: KANEBO LTD
发明人: MORITA KAZUYOSHI , TAKEMOTO TAIRA , MATSUI TADASHI , MORI KENJI , NAGASAWA HISANAO , OOTANI YASUNAGA , ARAI SOUICHI
摘要: PURPOSE:The titled grafting agent, obtained by bringing a free amino acid ester of p-toluenesulfonic acid expressed by a specific formula into contact with an alkaline medium, and eliminating p-toluenesulfonic acid, and having improved emulsifying and humectant property. CONSTITUTION:An amino acid alkyl, ester of p-toluenesulfonate is brought into contact with an alkaline medium, e.g. NaOH, and salted out preferably in the presence of a salt, e.g. NaCl, to afford a free amino acid ester expressed by formula I [R1 is amino acid residue; R2 is (un)saturated hydrocarbon], etc. The resultant amino acid ester and a hydrophilic protein, e.g. casein, are subjected to enzymic reaction. USE:An emulsifying agent for cosmetics and foods.
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公开(公告)号:JPS6030649B2
公开(公告)日:1985-07-17
申请号:JP12244382
申请日:1982-07-13
申请人: KANEBO LTD
发明人: MORI KENJI , MIURA YUMIKO , TAKEMOTO TAIRA
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