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    Pharmaceutical composition for treatment of disease due to vascular constriction or vasodilation
    3.
    发明专利
    Pharmaceutical composition for treatment of disease due to vascular constriction or vasodilation 有权
    用于治疗由血管扩张或血管扩张引起的疾病的药物组合物

    公开(公告)号：JP2012031201A

    公开(公告)日：2012-02-16

    申请号：JP2011239881

    申请日：2011-11-01

    申请人： Ono Pharmaceut Co Ltd ,  小野薬品工業株式会社

    发明人： NAKADE SHINJI ,  SUZUKI HIDEHIRO ,  HABASHITA HIROSHI

    IPC分类号： C07D211/48 ,  A61K31/437 ,  A61K31/445 ,  A61K31/451 ,  A61K31/4545 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D211/52 ,  C07D401/12 ,  C07D471/04 ,  C07D519/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/445 ,  C07D211/48

    摘要： PROBLEM TO BE SOLVED: To provide a therapeutic and/or preventing agent for a disease due to vascular constriction or vasodilation comprising an EDG-5 modulator EDG (Endothelia differentiation gene)-5 modulator; and also to provide a new EDG-5 antagonist.SOLUTION: A therapeutic and/or preventing agent for a disease due to vascular constriction or vasodilation comprises a EDG-5 modulator. Since EDG-5 modulator specifically binds EDG-5 and shows antagonistic or agonistic action, EDG-5 antagonist is useful for treating and/or preventing for a disease due to vascular constriction, for example, cerebrovascular spasmodic disorder after subarachnoid hemorrhage or stroke, cardiovasucular spasmodic disorder, hypertension, renal disease, cardiac infarction, cardiac angina, arrhythmia, facilitation of the portal blood pressure involved in liver cirrhosis, varicosity involved in liver cirrhosis and the like; or EDG-5 agonist is useful for treating and/or preventing for a disease due to vasodilation of blood vessels, for example, chronic headache (such as migraine, tension-type headache, mixed-type headache thereof, or migrainous neuralgia), haemorrhoid, congestive disorder and the like.

    摘要翻译： 要解决的问题：提供由于包含EDG-5调节剂EDG（内皮分化基因）-5调节剂的血管收缩或血管舒张引起的疾病的治疗和/或预防剂; 并提供新的EDG-5拮抗剂。 解决方案：由于血管收缩或血管舒张引起的疾病的治疗和/或预防剂包括EDG-5调节剂。 由于EDG-5调节剂特异性结合EDG-5并且具有拮抗作用或激动作用，因此EDG-5拮抗剂可用于治疗和/或预防由于血管收缩引起的疾病，例如蛛网膜下腔出血或中风后的脑血管性痉挛障碍 痉挛性疾病，高血压，肾脏疾病，心肌梗死，心脏心绞痛，心律失常，促进肝硬化引起的门静脉血压，涉及肝硬化的静脉曲张等; 或EDG-5激动剂可用于治疗和/或预防由于血管血管扩张引起的疾病，例如慢性头痛（如偏头痛，紧张型头痛，混合型头痛或偏头痛神经痛），痔疮 ，充血障碍等。 版权所有（C）2012，JPO＆INPIT

    Carbohydrate metabolism improving agent
    7.
    发明专利
    Carbohydrate metabolism improving agent 审中-公开
    碳水化合物代谢改良剂

    公开(公告)号：JP2005162720A

    公开(公告)日：2005-06-23

    申请号：JP2003407909

    申请日：2003-12-05

    申请人： Ono Pharmaceut Co Ltd ,  小野薬品工業株式会社

    发明人： NAKADE SHINJI ,  HABASHITA HIROSHI

    IPC分类号： A61K45/00 ,  A61K31/196 ,  A61K31/197 ,  A61K31/44 ,  A61K45/06 ,  A61P1/18 ,  A61P3/10

    摘要： PROBLEM TO BE SOLVED: To provide a carbohydrate metabolism improving agent, particularly provide a new agent that is useful for treating type II diabetes. SOLUTION: This carbohydrate metabolism improving agent that contains EDG-1 agonist. The carbohydrate metabolism improving agent that includes EDG-1 agonist, particularly, a compound that is represented by general formula (I) (wherein the ring A is a ring-forming group; the ring B is a ring-forming group which may be substituted; X and Y mean each a spacer or the like; Z is an acid group; R1 is a substituent or the like) or a salt thereof and a solvate thereof or their products are useful as an insulin secretion promotor, glucose tolerance improver and/or islet pancreas cell protector, thus they can be used for prevention and/or therapy of diabetes, particularly type II diabetes of human and nonhuman mammals, for example, monkey, sheep, cattle, horse, dog, cat, rabbit, rat, mouse or the like. COPYRIGHT: (C)2005,JPO&NCIPI

    摘要翻译： 要解决的问题：提供碳水化合物代谢改善剂，特别是提供可用于治疗II型糖尿病的新药物。

    解决方案：含有EDG-1激动剂的碳水化合物代谢改善剂。 包括EDG-1激动剂的碳水化合物代谢改善剂，特别是由通式（I）表示的化合物（其中环A是成环基团;环B是可以被取代的成环基团） X和Y分别表示间隔基等，Z为酸基，R 1为取代基等）或其盐及其溶剂合物或其产物可用作胰岛素分泌促进剂，葡萄糖耐量改善剂和/ 或胰岛胰腺细胞保护剂，因此它们可用于预防和/或治疗糖尿病，特别是人和非人哺乳动物的II型糖尿病，例如猴，绵羊，牛，马，狗，猫，兔，大鼠，小鼠 或类似物。 版权所有（C）2005，JPO＆NCIPI