公开(公告)号：JP2005112728A

公开(公告)日：2005-04-28

申请号：JP2003345090

申请日：2003-10-02

Applicant: Takasago Internatl Corp ,  高砂香料工業株式会社

Inventor： MATSUMOTO TAKASHI ,  FUJIWARA MITSUHIKO ,  NARA HIDEKI ,  YAMADA SHINYA

IPC: C07F3/02 ,  C07D477/04 ,  C07F7/18 ,  C07F9/6561

CPC classification number: C07D477/04 ,  C07F7/1892 ,  C07F9/65611 ,  Y02P20/55

Abstract: PROBLEM TO BE SOLVED: To provide a method of obtaining carbapenem compounds useful as intermediates for the synthesis of carbapenem compounds under mild conditions in a short step in a good yield by solving the problems of the conventional method. SOLUTION: The method for producing the carbapenem compounds comprises performing the reaction represented by formula (3) (wherein R 1 and R 2 are each hydrogen or a lower alkyl group; R 3 is a hydrogen atom or a lower alkyl group; R 4 is a protective group for hydrogen and a hydroxy group; R 5 is a protective group for a carboxy group; R 8 is a 1-12C alkyl group or the like; R 9 is a 1-12C alkyl group, a halogen or the like; Y is an active ester group or the like; and L is an active ester group of a hydroxy group) in the presence of a magnesium compound. COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 待解决的问题：提供一种通过解决常规方法的问题，以短期步骤获得用作碳酸青霉烯化合物的温和条件合成中间体的碳青霉烯化合物的方法。 解决方案：制备碳青霉烯化合物的方法包括进行由式（3）表示的反应（其中R 1 和R 2 各自为氢或低级烷基 基团; R 3是一个氢原子或一个低级烷基; R 4是保护氢和羟基的基团; R“SP”5 是羧基的保护基; R 16是1-12C烷基等; R 11是1-12C烷基，卤素或 Y为活性酯基等，L为羟基的活性酯基）。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2005095155A

公开(公告)日：2005-04-14

申请号：JP2004234705

申请日：2004-08-11

Applicant: Takasago Internatl Corp ,  高砂香料工業株式会社

Inventor： WATABE MASAYA ,  YAMADA SHINYA ,  FUJIWARA MITSUHIKO ,  SAYO NOBORU

IPC: C12P41/00

Abstract: PROBLEM TO BE SOLVED: To provide a method for easily and efficiently producing alcohols and esters in which a ratio of a specified stereoisomer (geometric isomer) is increased, by using an enzyme derived from a microorganism, without using enzymes derived from animals difficult to be massively supplied, nor enzymes derived from plants having problems in handling.
SOLUTION: This method for obtaining the alcohol having a high steric purity of the specified geometric isomer comprises subjecting a geometrically isomeric alcohol mixture to half esterification with an acid anhydride in the presence of a hydrolase, or subjecting the mixture to transesterification reaction with a carboxylic acid ester used as a substitute for the acid anhydride, so as to obtain a half ester or an ester in which the ratio of the specified geometric isomer is increased, and then subjecting the half ester or the ester thus obtained to a hydrolyzing operation, etc., according to ordinary procedures.
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种通过使用来源于微生物的酶而不使用源自动物的酶，容易且有效地制备其中特定的立体异构体（几何异构体）的比率增加的醇和酯的方法 难以大量供应，也不是源于植物问题的酶。 解决方案：用于获得具有特定几何异构体的高空间纯度的醇的方法包括在水解酶存在下使几何异构醇混合物与酸酐进行半酯化反应，或将混合物进行酯交换反应， 用作酸酐的替代物的羧酸酯，以获得其中指定的几何异构体的比例增加的半酯或酯，然后将由此获得的半酯或酯进行水解操作 等等，按照普通程序。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2004315465A

公开(公告)日：2004-11-11

申请号：JP2003114111

申请日：2003-04-18

Applicant: Takasago Internatl Corp ,  高砂香料工業株式会社

Inventor： NAKAMURA JUNJI ,  YAMADA SHINYA ,  KENMOCHI HIROYUKI ,  HORI YASUSHI

IPC: C07D307/00 ,  C08F20/28

Abstract: PROBLEM TO BE SOLVED: To provide a new monomer compound having a lactone structure and giving a polymer having improved properties as a resist material, etc.
SOLUTION: The compound is expressed by general formula (1) (one of R
1 and R
2 is methyl and the other is isopropyl; one of R
3 and R
4 is H and the other is hydroxy, acryloyloxy or methacryloyloxy; R
5 and R
6 are each independently H or an alkyl; X is (R
7 )(R
8 )C-C(R
9 )(R
10 ); and R
7 , R
8 , R
9 and R
10 are each independently H or an alkyl).
COPYRIGHT: (C)2005,JPO&NCIPI

Abstract translation: 要解决的问题：提供具有内酯结构的新型单体化合物，并提供具有改进性能的聚合物作为抗蚀剂材料等。溶液：该化合物由通式（1）表示（1 R 1 和R 2 是甲基，另一个是异丙基; R 3和R 4中的一个是H 另一个是羟基，丙烯酰氧基或甲基丙烯酰氧基; R 5和R 6共同独立地是H或烷基; X是（R SP 7） （R 8 ）CC（R 9 ）（R 10 ）; R R 4，R 10和R 10各自独立地为H或烷基。 版权所有（C）2005，JPO＆NCIPI

公开(公告)号：JP2012115726A

公开(公告)日：2012-06-21

申请号：JP2010265555

申请日：2010-11-29

Applicant: Takasago Internatl Corp ,  高砂香料工業株式会社

Inventor： YAMADA SHINYA ,  MAEDA HIRONORI ,  HORI YASUSHI

IPC: B01J31/28 ,  C07B53/00 ,  C07B61/00 ,  C07C45/62 ,  C07C47/21

CPC classification number: B01J31/04 ,  B01J21/12 ,  B01J23/40 ,  B01J23/44 ,  B01J23/74 ,  B01J23/755 ,  B01J27/053 ,  B01J29/068 ,  B01J29/072 ,  B01J31/062 ,  B01J31/1616 ,  B01J31/2217 ,  B01J31/26 ,  B01J2231/645 ,  B01J2531/0275 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/847 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/62 ,  Y02P20/588 ,  C07C47/21

Abstract: PROBLEM TO BE SOLVED: To provide a catalyst for producing optically-active aldehydes or ketones being optically-active carbonyl compounds by selectively asymmetrically hydrogenating α, β-unsaturated carbonyl compounds, particularly a catalyst insoluble in a reaction mixture for obtaining an optically-active citronellal useful as a perfume by selectively asymmetrically hydrogenating citral, geranial or neral; and also to provide a method for producing corresponding optically-active carbonyl compounds.SOLUTION: The invention relates to a catalyst for asymmetrically hydrogenating α, β-unsaturated carbonyl compounds, which contains: the powder of at least one metal selected from group 8-10 metals in the periodic table, or a metal-supported material in which at least one metal selected from group 8-10 metals is supported by a carrier; an optically-active peptide compound; and an acid, and also relates to a method for producing optically-active carbonyl compounds using the catalyst.

Abstract translation: 要解决的问题：提供一种用于通过选择性不对称氢化α，β-不饱和羰基化合物，特别是不溶于反应混合物中的催化剂以获得光学活性的羰基化合物来提供用于制备光学活性的醛或酮的催化剂， 活性香茅醛通过选择性不对称氢化柠檬醛，香叶酸或香草来用作香料; 并且还提供了制备相应的光学活性羰基化合物的方法。 解决方案：本发明涉及用于不对称氢化α，β-不饱和羰基化合物的催化剂，其包含：选自周期表中第8-10族金属中的至少一种金属的粉末或金属负载材料 其中选自第8-10族金属中的至少一种金属由载体支撑; 光学活性肽化合物; 和酸，还涉及使用该催化剂制备光学活性羰基化合物的方法。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2012131785A

公开(公告)日：2012-07-12

申请号：JP2011262574

申请日：2011-11-30

Applicant: Takasago Internatl Corp ,  高砂香料工業株式会社

Inventor： MAEDA HIRONORI ,  ITO HISANORI ,  YAMADA SHINYA ,  HORI YASUSHI

IPC: C07C29/156 ,  B01J25/02 ,  B01J31/22 ,  B01J31/28 ,  C07B53/00 ,  C07B57/00 ,  C07B61/00 ,  C07C35/12

CPC classification number: C07C29/132 ,  B01J21/18 ,  B01J23/44 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/17 ,  C07C29/56 ,  C07C2601/14 ,  C07C35/12 ,  C07C35/17

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing optically-active menthol, which is composed of a few steps that are all catalytic reaction steps, therefore producing little environment-polluting waste, and can achieve a reduction in the manufacturing cost.SOLUTION: The method for producing optically-active menthol includes steps of: (A-1) subjecting at least one of geranial and neral to asymmetric hydrogenation to obtain optically active citronellal; (B-1) subjecting the optically active citronellal to ring-closing reaction with an acid catalyst to obtain optically active isopulegol; and (C-1) hydrogenating the optically active isopulegol to obtain optically active menthol.

Abstract translation: 要解决的问题：提供一种由全部催化反应步骤的几个步骤组成的光学活性薄荷醇的方法，因此几乎不产生环境污染的废物，并且可以实现制造成本的降低 。 解决方案：用于制备光学活性薄荷醇的方法包括以下步骤：（A-1）将至少一种龙涎香和不饱和氢化物进行不对称氢化以获得光学活性的香茅醛; （B-1）使光学活性香茅醛与酸催化剂进行闭环反应，得到光学活性的异胡前药; 和（C-1）氢化旋光异黄酮获得光学活性薄荷醇。 版权所有（C）2012，JPO＆INPIT