Abstract:
PROBLEM TO BE SOLVED: To provide an array for spotting a material in the form of a print on the surface of a substrate. SOLUTION: The array 1 includes a bottom plate 12 and studs 14 fixedly provided at the end part of the first face 121 of the bottom plate. The studs are disposed on the first face 121 of the bottom plate 12 so that the faces 141 of all studs 14 fixedly provided on the bottom plate 12 can be almost simultaneously brought into contact with the surface of the substrate. A manufacturing method of the array, and also a method for almost simultaneously spotting many material prints which are the same or not the same on the surface of the substrate by using the array 1 are provided in order to perform analysis are provided. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
The present invention relates to functional elements that comprise microstructures containing biofunctionalized nanoparticles arranged on a carrier, a method for the production of these functional elements and the use thereof.
Abstract:
In a macro-stamper (1), for depositing materials (A) on a substrate surface (B), comprising studs (14) fixed to a base and having a flat face (141) for retaining solution of (A) at the free end, all of the flat faces being contactable with (B) simultaneously, at least one of the flat faces carries a motif of the shape in which (A) is to be deposited on (B). A macro-stamper (1), for depositing materials (A) on a substrate surface (B), comprises a base (12), with a first (lower) face (121), and studs (14) fixed to the base. Each stud has an axis perpendicular to the first face, one end fixed to the first face and an opposite (free) end with a flat face (141), locally parallel to a plane tangential to the first face, for retaining solution of (A). The studs are mounted on the lower face so that the flat faces of all of the studs can contact (B) simultaneously. The novel feature is that at least one of the flat faces carries a motif (i.e. a uniform surface or spot, periodic geometric motif and/or light diffracting complex geometric motif) of the shape in which (A) is to be deposited on (B), the dimensions of the studs and motifs being in the millimeter and nanometer ranges respectively. Independent claims are included for: (1) the production of the macro-stamper (1), by (a) placing a mold, crossed by hollow indentations reproducing the size and location of the studs (14), on and in contact with one face of a plate; (b) filling the indentations with curable material(s) for forming the stamper after curing; and (c) extracting the stamper from the mold; and (2) a method for simultaneously depositing materials (A) on a substrate surface using the macro-stamper (1), involving (i) depositing solutions of (A) on the faces (141) of the studs (14) of the stamper, (ii) partially drying the solutions and (iii) rapidly applying the stamper to (B), so that (A) are deposited simultaneously on (A) in a pattern of prints reproducing the shapes of the stud faces.
Abstract:
PROBLEM TO BE SOLVED: To provide a biochip producing device that can shorten a biochip producing period, prevents mixing of different kinds of biopolymer solutions, and can easily obtain a uniform site. SOLUTION: The biochip producing device for arranging many different biopolymers on a substrate of the biochip comprises a support body movable in any direction, an integrally constituted stamp attached to the support body, and a biopolymer solution feeder for feeding two or more kinds of different biopolymer solutions adhering to the stamp tip. The biopolymer solutions are stuck to the stamp tip from the biopolymer solution feeder, and the stamp is pressed onto the substrate of the biochip, thereby sticking the biopolymer solutions to the substrate surface of the biochip in the arrangement same as that of the stamp to simultaneously form a plurality of sites. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract:
PROBLEM TO BE SOLVED: To provide a method for mass-producing microstructures, in particular, nanometer level structures such as biochips, protein chips, quantum dots, quantum chips and the like. SOLUTION: Antigens 12 are arranged in a two-dimensional form on a substrate 11, and probes 13 are arranged in the two-dimensional form so as to head along a fixed direction in order to combine its joint section with the antigens 12. A thin film layer 16 is made up by depositing an inorganic material such as Ni or the like on the probes 13 on the substrate 11 in a sputtering process or a vacuum evaporation process, and a support layer 17 is made up on the upper surface of the evenly formed thin film layer 16 by depositing the same inorganic material in an electroforming process. Then, the thin film layer 16 and the support layer 17 are separated from the substrate 11, thereby obtaining a mother stamper 18 with a cavity 19 having the geometry of a living body. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract:
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.
Abstract:
Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate.