摘要:
The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要:
PROBLEM TO BE SOLVED: To provide compositions, apparatuses and methods useful for concurrently performing in high throughput a large number of biological or chemical assays using repeated arrays of probes. SOLUTION: A combination includes a surface having a plurality of test regions. At least 2 of the plurality of test regions, in a preferred embodiment at least 20 of the test regions, are substantially identical, wherein each of the test regions includes an array of general anchor molecules. The anchors are associated with bifunctional linker molecules. The bifunctional linker molecules contain each a portion which is specific for at least one of the anchors and a portion which is a probe specific for a target of interest. The resulting array of probes is used to analyze the presence or test the activity of one or more target molecules specifically interacting with the probes. In a preferred embodiment, a sample to be tested is brought to contact with the combination after the sample has been treated by a nuclease protection procedure. COPYRIGHT: (C)2010,JPO&INPIT
摘要:
PROBLEM TO BE SOLVED: To provide a reactive hydrophilic coating and hydrogel which can be applied to various substrates for the purpose of covalently attaching a functional material to a substrate. SOLUTION: The crosslinked hydrogel for coating the substrate comprises at least one azlactone-functional copolymer which comprises: a plurality of azlactone moieties; a plurality of azlactone functional groups; and at least one comonomer, and at least one kind of crosslinking agent having a first moiety and a second moiety, wherein the first moiety of a first crosslinking agent is covalently bound to a first azlactone moiety and the second moiety of the first crosslinking agent is covalently bound to a second azlactone moiety or a second crosslinking agent. COPYRIGHT: (C)2010,JPO&INPIT
摘要:
PROBLEM TO BE SOLVED: To provide a preferred sample storing method and system. SOLUTION: The sample storing method and system implement a plurality of sample carriers configured to support a plurality of samples nodes in a predetermined spatial relationship, sample storage devices for selectively placing the plurality of sample carriers in an archive, and a sample node removal apparatus for locating and removing selected ones of the plurality of sample nodes. Alternative embodiments are disclosed wherein the sample node removal apparatus includes a laser and a mechanical clipping tool, which may be manually operated or automated. COPYRIGHT: (C)2010,JPO&INPIT
摘要:
This is invention is directed to methods of identifying analytes that are differentially present between two samples. The methods involve determining retention data by desorption spectrometry for analytes in different samples using the same selectivity conditions, comparing the data, and identifying analytes that are differentially retained.
摘要:
PROBLEM TO BE SOLVED: To provide a system and a method for retentate chromatography. SOLUTION: This preparing method of the base for detecting at least a single analyte in sample, include (a) a process for exposing the above sample in at least two different selection conditions, where each selection condition is defined by combination of absorbent and eluent to enable retention of the analyte with the absorbent; (b) a process for using desorption spectrometry to determine at least one selection condition in which the analyte is retained; and (c) a process for preparing the base containing at least one absorbent of the determined selection condition. COPYRIGHT: (C)2007,JPO&INPIT