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    Separation of blood constituents
    6.
    发明专利
    Separation of blood constituents 失效
    血液分离

    公开(公告)号：JPS5731621A

    公开(公告)日：1982-02-20

    申请号：JP9516581

    申请日：1981-06-19

    申请人： Max Planck Gesellschaft

    发明人： YOZEFU HAA BUIIZERAA

    IPC分类号： G01N33/48 ,  A61K35/16 ,  A61K38/16 ,  A61K39/00 ,  B01J20/281 ,  C07K14/435 ,  G01N30/88

    CPC分类号： A61K35/16 ,  Y10S530/83

    摘要： The invention relates to a process for producing and obtaining anaphylatoxin- and cocytotaxin-containing leucotaxine preparations and anaphylatoxin and cocytotaxin proteins in molecularly homogeneous, biologically active form from contact-activated mammalian serum by the following steps: separation of the proteins from other serum constituents to obtain a serum protein concentrate fraction, separation of a part of accompanying foreign blood proteins from anaphylatoxin and cocytotaxin present in the said protein concentrate fraction, isolation of the leucotaxine preparation by chromatography on hydroxyapatite, and optionally further purification and/or separation of the leucotaxine preparation into anaphylatoxin and cocytotaxin proteins by chromatographical methods. The invention is characterized in that, prior to chromatography on hydroxyapatite, in the above-mentioned process, a major fraction of accompanying foreign blood constituents is separated from the said serum protein concentrate fraction by fractional elution and/or precipitation with a water-soluble alcohol and/or at least one molecular sieve filtration.