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    Prostaglandin d-mimic compound, its preparation and antitumor agent containing the same
    9.
    发明专利
    Prostaglandin d-mimic compound, its preparation and antitumor agent containing the same 失效
    PROSTAGLANDIN D-MIMIC化合物，其制备和含有它的抗菌剂

    公开(公告)号：JPS595155A

    公开(公告)日：1984-01-12

    申请号：JP11275782

    申请日：1982-06-30

    申请人： Ono Pharmaceut Co Ltd

    发明人： WAKATSUKA HIROHISA ,  YAMATO TAKASHI ,  HASHIMOTO SHINSUKE

    IPC分类号： A61K31/557 ,  A61K31/5575 ,  A61P35/00 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/937 ,  C08B37/00

    CPC分类号： C07D307/937 ,  C07C405/00 ,  C08B37/0015

    摘要： NEW MATERIAL:The compound of formula I ([A] is group of formula II W formula IV; when [A] is group of formula II, C
    13 -C
    14 -C
    15 is group of formula V, and when [A] is group of formula III or formula IV, it is group of formula VI; R is H or 1W12C alkyl; R
    1 is single bond or 1W5C alkylene; R
    2 is 1W8C alkyl, etc.; the configuration of C
    9 -C
    10 in group of formula IV is Z, that of C
    13 - C
    14 in group of formula V is E and those of C
    12 -C
    13 and C
    14 -C
    15 are E, Z or EZ; when R
    1 is single bond, R
    2 is not substituted or unsubstituted phenoxy), its cyclodextrin-clathrate compound, or when R=H, its salt.
    EXAMPLE: 6-Keto-PGD
    1 methyl ester.
    USE: An antitumor agent.
    PROCESS: A compound of formula I wherein [A] is group of formula II or formula III can be prepared by hydrolyzing the compound of formula VII (R
    3 is 1- ethoxyethyl, etc.; R
    4 is lower alkyl) under acidic condition. The product wherein [A] is group of formula II can be converted to anothr compound of formula I wherein [A] is group of formula IV by reacting in an aqueous solution of an acid.
    COPYRIGHT: (C)1984,JPO&Japio

    摘要翻译： 新物质：式I化合物（[A]是式Ⅱ-式IV的基团;当[A]为式II基团时，C13-C14-C15为式V基团，当[A]为 式III或式IV，它是式VI的基团; R是H或1-12C烷基; R 1是单键或1-5C亚烷基; R 2是1-8C烷基等;配置 式Ⅴ基团中的C 9 -C 10的化合物是Z，式Ⅴ中C 13 -C 14的化合物是E，C 12 -C 13和C 14 -C 15的那些是E，Z或EZ;当R 1是单键时， R 2不是取代或未取代的苯氧基），其环糊精包合物，或当R = H时，其盐。 实施例：6-酮-PGD1甲酯。 用途：抗肿瘤剂。 方法：其中[A]是式II或式III基团的式I化合物可以通过水解式VII化合物（R 3是1-乙氧基乙基等; R 4是低级烷基）来制备， 在酸性条件下。 其中[A]是式II基团的产物可以通过在酸的水溶液中反应而转化为式I化合物，其中[A]是式IV基团。