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    Continuous process for alkylation of cyclic tertiary amine
    5.
    发明专利
    Continuous process for alkylation of cyclic tertiary amine 有权
    循环胺连接方法

    公开(公告)号：JP2013133335A

    公开(公告)日：2013-07-08

    申请号：JP2012261150

    申请日：2012-11-29

    申请人： Cerbios - Pharma Sa ,  セルビオス − ファルマ・エス・アーCerbios − Pharma Sa

    发明人： MEREU ANDREA ,  MOROSOLI MORENO ,  PERSEGHINI MAURO ,  SPREAFICO ALESSANDRO

    IPC分类号： C07D207/12 ,  C07D451/10

    CPC分类号： C07D451/00 ,  C07D207/12 ,  C07D209/94 ,  C07D451/12 ,  C07D491/04

    摘要： PROBLEM TO BE SOLVED: To provide a continuous process for alkylation of a tertiary amine, particularly, a continuous process for quaternization of a cyclic tertiary amine useful for production of a highly pure cyclic quaternary ammonium salt.SOLUTION: The continuous process for alkylation of a tertiary amine includes continuous supply of a solution of a cyclic tertiary amine in a preferred solvent or a mixture of a plurality of solvents and optionally continuous supply of a solution of an alkylating agent dissolved in a preferred solvent or a mixture of plurality of solvents, to a continuous flow reactor; maintenance of the temperature in a range of from 20 to 200°C; recovery of a solution containing the pure quaternary cyclic ammonium compound; and then isolation of the pure quaternary cyclic ammonium compound. Specifically, the continuous method includes production of tiotropium bromide, glycopyrronium bromide and ipratropium bromide.

    摘要翻译： 要解决的问题：提供用于烷基化叔胺的连续方法，特别是用于季铵化用于生产高纯度环状季铵盐的环状叔胺的连续方法。溶液：用于烷基化的连续方法 叔胺包括在优选的溶剂或多种溶剂的混合物中连续供应环状叔胺的溶液，并且任选地连续供应溶解在优选的溶剂或多种溶剂的混合物中的烷基化剂的溶液， 连续流动反应器; 将温度维持在20〜200℃的范围内; 回收含有纯的季铵化合物的溶液; 然后分离纯的季铵化合物。 具体来说，连续方法包括生产噻托溴铵，溴化格列溴铵和异丙托溴铵。