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公开(公告)号：US10941198B2
公开(公告)日：2021-03-09
申请号：US16133352
申请日：2018-09-17
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , G01N33/564 , G01N33/68 , A61K47/68
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10081676B2
公开(公告)日：2018-09-25
申请号：US14902394
申请日：2014-07-03
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Shimobi Onuoha , Paert Peterson , Mike Rothe , Martin Woodward , Syeda F. Y. Haque
IPC分类号： A61K39/395 , C12N15/09 , C07K16/24 , G01N33/68 , A61K39/00
摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10112995B2
公开(公告)日：2018-10-30
申请号：US14902409
申请日：2014-07-03
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , C07H21/04 , G01N33/564 , G01N33/68 , A61K47/48
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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公开(公告)号：US11945861B2
公开(公告)日：2024-04-02
申请号：US17154350
申请日：2021-01-21
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. Haque , Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Steffen Meyer , Paert Peterson , Mike Rothe , Philip Vlaicu , Martin Woodward
IPC分类号： C07K16/24 , A61K47/68 , G01N33/564 , G01N33/68
CPC分类号： C07K16/249 , A61K47/6845 , G01N33/564 , G01N33/6866 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N2333/56
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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5.发明授权公开(公告)号：US10975144B2
公开(公告)日：2021-04-13
申请号：US16107889
申请日：2018-08-21
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Kisand , Kai Krohn , Annalisa Macagno , Shimobi Onuoha , Paert Peterson , Mike Rothe , Martin Woodward , Syeda F. Y. Haque
摘要： Provided are novel IL-32 binding molecules of human origin, particularly human anti-IL-32 antibodies as well as IL-32 binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
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公开(公告)号：US20170051055A1
公开(公告)日：2017-02-23
申请号：US14902409
申请日：2014-07-03
申请人： IMMUNOQURE AG
发明人： Syeda F.Y. HAQUE , Adrian HAYDAY , Kai KISAND , Kai KROHN , Annalisa MACAGNO , Steffen MEYER , Paert PETERSON , Mike ROTHE , Philip VLAICU , Martin WOODWARD
IPC分类号： C07K16/24 , G01N33/564 , G01N33/68
CPC分类号： C07K16/249 , A61K47/6845 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/564 , G01N33/6866 , G01N2333/56
摘要： Provided are novel IFN-α binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy are described.
摘要翻译： 提供了人源的新型IFN-α结合分子，特别是人源抗体IFN-α抗体以及IFN-α结合片段，其衍生物和变体。 此外，描述了用于诊断和治疗的药物组合物，试剂盒和方法。
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公开(公告)号：US20210221883A1
公开(公告)日：2021-07-22
申请号：US17154350
申请日：2021-01-21
申请人： IMMUNOQURE AG
发明人： Syeda F. Y. HAQUE , Adrian HAYDAY , Kai KISAND , Kai KROHN , Annalisa MACAGNO , Steffen MEYER , Paert PETERSON , Mike ROTHE , Philip VLAICU , Martin WOODWARD
IPC分类号： C07K16/24 , G01N33/564 , G01N33/68 , A61K47/68
摘要： Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-α antibodies as well as IFN-α binding fragments, derivatives and variants thereof. In addition, pharmaceutical compositions, kits, and methods for use in diagnosis and therapy are described.
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公开(公告)号：US10131709B2
公开(公告)日：2018-11-20
申请号：US15258263
申请日：2016-09-07
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa Macagno , Shimobi Onuoha
摘要： Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
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公开(公告)号：US09957319B2
公开(公告)日：2018-05-01
申请号：US14368749
申请日：2013-01-02
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa Macagno
IPC分类号： C07K16/24 , C07K16/06 , C07K16/18 , C07K16/00 , G01N33/569 , A61K39/395 , A61K45/06 , C07K16/42 , G01N33/68 , A61K39/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/065 , C07K16/18 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N2501/599 , G01N33/56972 , G01N33/6869 , G01N2333/54
摘要： Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human antibodies from memory B cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described.
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10.发明授权公开(公告)号：US09475872B2
公开(公告)日：2016-10-25
申请号：US14369467
申请日：2013-01-02
申请人： IMMUNOQURE AG
发明人： Adrian Hayday , Kai Krohn , Annamari Ranki , Part Peterson , Kai Kisand , Edward Stuart , Annalisa MacAgno , Shimobi Onuoha
IPC分类号： C12N15/09 , C07K16/24 , C07K16/06 , C07K16/18 , C07K16/00 , G01N33/569 , A61K39/395 , A61K45/06 , C07K16/42 , G01N33/68 , A61K39/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/065 , C07K16/18 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N2501/599 , G01N33/56972 , G01N33/6869 , G01N2333/54
摘要： Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
摘要翻译： 提供了人源的新型结合分子，特别是人抗体以及其识别抗原的片段，衍生物和变体，例如与免疫应答，自身免疫性疾病，炎性疾病，代谢紊乱，血管功能，神经变性相关的天然内源蛋白 疾病或肿瘤。 更具体地，提供人自身免疫体和相应的单克隆抗体储库。 此外，描述了用于诊断和治疗的药物组合物，试剂盒和方法。
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