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公开(公告)号：US11752337B2
公开(公告)日：2023-09-12
申请号：US16981505
申请日：2020-05-20
IPC分类号： A61N1/36
CPC分类号： A61N1/36025 , A61N1/36031 , A61N1/36034
摘要： Real time mirroring of dominant brain frequencies through the use of two types of stimuli is provided. Through devices and methods that simultaneously look for asymmetries and in real time, one can create real time variable sequences of acoustic and electric stimuli, and then one can effectively and efficiently support the brain to balance its activity between corresponding right and left lobes without one's mindful attention.
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公开(公告)号：US10470593B2
公开(公告)日：2019-11-12
申请号：US16437692
申请日：2019-06-11
发明人： Brett S. Kalm , Karla Lopez
摘要： A product display tester unit is provided to allow for the efficient and effective display of goods, such as creams, lotions, and serums. The display tester unit comprises a fluted panel, a ledge and a base. The display tester unit may be used as part of a display system, and its components are reversibly associated within one another.
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公开(公告)号：US10010623B2
公开(公告)日：2018-07-03
申请号：US14378138
申请日：2013-02-05
申请人： UCL Business PLC
IPC分类号： A61K47/68 , A61K31/537 , A61K47/48 , A61K31/704 , C07D207/24 , C07H15/26 , C07K16/18 , A61K39/00
摘要： The present invention relates to a linker for forming conjugates of a protein or peptide with a therapeutically active agent and which comprise a thiomaleamic acid moiety that is susceptible to cleavage under the pH conditions prevalent in the lysosome.
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公开(公告)号：US09943880B2
公开(公告)日：2018-04-17
申请号：US15041086
申请日：2016-02-11
申请人： Yodle Ventures LLC
发明人： Jason Dorf
CPC分类号： B05D5/06 , B05C1/00 , B05D2203/00 , B41M5/24 , B41M5/26 , B44C1/00 , D06P5/002 , D06P5/003 , D06P5/20 , D06P7/00
摘要： Kits and methods are provided for color customization of articles by applying ink to regions of decreased pigment density. By creating tension over these regions during application of the ink, the ink may be preferentially transferred to those regions.
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公开(公告)号：US09826792B2
公开(公告)日：2017-11-28
申请号：US14916217
申请日：2014-10-28
发明人： Paul Dowd , Philippe M. Putzeys
CPC分类号： A42B3/0473 , A42B3/185
摘要： Devices that facilitate offsetting of weight of heard borne equipment such as helmets and other devices associated with helmets are provided. Through the use of pivots and an arm assembly that distributes weight from a person's head to his or her torso, additional and heavier objects can be carried on a person's head without causing undesirable levels of discomfort.
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公开(公告)号：US09719094B2
公开(公告)日：2017-08-01
申请号：US15255973
申请日：2016-09-02
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.
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公开(公告)号：US09327814B2
公开(公告)日：2016-05-03
申请号：US13566226
申请日：2012-08-03
申请人： Rick Packer
发明人： Rick Packer
CPC分类号： B63H16/04 , Y10T403/602
摘要： A joint is provided for a double bladed paddle which allows for the angle between the blades to be adjusted relative to one another. The joint is formed from joining a female body recessed into a first shaft with a male body extending from a second shaft. The female body encloses a spring mechanism abutted by teeth of a crown with receiving grooves. The male body has protuberances which fit within the receiving grooves leading to the spring mechanism which when pushed in by the male body allows the protuberances to move past the receiving grooves and rotate to slot into the pockets formed between the teeth of the crown.
摘要翻译： 提供了一种用于双叶片的接头，其允许叶片之间的角度相对于彼此调节。 接头是从凹入第一轴的凹形体与从第二轴延伸的凸形体接合形成的。 雌体包围一个弹簧机构，该弹簧机构与具有接收凹槽的牙冠的齿接合。 阳体具有装配在通向弹簧机构的接收槽内的突起，当通过阳体推动时，凸起允许突起移动通过接收槽并且旋转到槽中形成在冠的齿之间的凹穴中。
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公开(公告)号：US09117251B2
公开(公告)日：2015-08-25
申请号：US13718872
申请日：2012-12-18
申请人： Jameslevi Schmidt , Jun Shimada , Mei Shibata , Ben Hertz-Shargel
发明人： Jameslevi Schmidt , Jun Shimada , Mei Shibata , Ben Hertz-Shargel
摘要： The present invention is directed to methods and systems for control of loads that are connected to plugs. Through the use of various embodiments of the present invention one may allow a plurality of users to control the use of power by individual loads and dynamically configurable sets of loads with ease, on both small and large scales. Users may select from energy savings plans to generate compiled device power state schedules that automatically cause devices to enter power savings modes as pre-determined times. Consequently, one can efficiently manage plug load electricity usage in a plurality of buildings.
摘要翻译： 本发明涉及用于控制连接到插头的负载的方法和系统。 通过使用本发明的各种实施例，可以允许多个用户在小尺寸和大尺度上容易地通过单独的负载和动态可配置的负载集来控制功率的使用。 用户可以从节能计划中选择生成编译的设备电源状态调度，自动使设备进入节电模式作为预定时间。 因此，可以有效地管理多个建筑物中的插头负荷用电量。
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10.发明授权Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference 有权三重寡核苷酸复合物和通过RNA干扰进行基因沉默的方法公开(公告)号：US08809514B2
公开(公告)日：2014-08-19
申请号：US12442278
申请日：2007-09-20
IPC分类号： C07H21/00 , C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C07H19/00 , C12N15/11 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2310/3515 , C12N2320/32 , C12N2330/30 , C12N2310/3521
摘要： Provided herein are tripartite oligonucleotide complexes which can be administered to a cell, tissue or organism to silence a target gene. The tripartite oligonucleotide complexes of the disclosure may include a conjugate moiety that facilitates delivery to a cell, tissue or organism without the aid of a transfection reagent.
摘要翻译： 本文提供了可以向细胞，组织或生物体施用以沉默靶基因的三极寡核苷酸复合物。 本公开的三极寡核苷酸复合物可以包括有助于在不用转染试剂的帮助下递送至细胞，组织或生物体的缀合物部分。
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