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公开(公告)号:US5929251A
公开(公告)日:1999-07-27
申请号:US565
申请日:1997-12-30
申请人: Peter Pochlauer , Wolfram Hendel , Christian Burger , Anita Lamplmayr , Harald Poschko , Antonia Praus , Gerald Summer
发明人: Peter Pochlauer , Wolfram Hendel , Christian Burger , Anita Lamplmayr , Harald Poschko , Antonia Praus , Gerald Summer
IPC分类号: B01J23/04 , B01J27/232 , B01J31/02 , C07B61/00 , C07D207/46 , C07D207/12
CPC分类号: C07D207/46
摘要: Process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 together form a C.sub.6 -aryl radical, in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. and isolation of the corresponding carboxylic acid succinimidyl ester.
摘要翻译: 通过N-羟基琥珀酰亚胺与羧酸和下式的卤代磷酸酯的反应制备羧酸琥珀酰亚胺酯的方法,其中R 1和R 2相同或不同,并且是C 2 -C 6烷基或苯基 或者R1和R2一起形成C 6 - 芳基,在碱存在下,在稀释剂中,在0℃至100℃的温度下,分离相应的羧酸琥珀酰亚胺酯。
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公开(公告)号:US5734064A
公开(公告)日:1998-03-31
申请号:US833120
申请日:1997-04-04
申请人: Peter Pochlauer , Wolfram Hendel , Christian Burger , Anita Lamplmayr , Harald Poschko , Antonia Praus , Gerald Summer
发明人: Peter Pochlauer , Wolfram Hendel , Christian Burger , Anita Lamplmayr , Harald Poschko , Antonia Praus , Gerald Summer
IPC分类号: B01J23/04 , B01J27/232 , B01J31/02 , C07B61/00 , C07D207/46
CPC分类号: C07D207/46
摘要: A process for the preparation of carboxylic acid succinimidyl esters by reaction of N-hydroxysuccinimide with a carboxylic acid and a halophosphoric acid ester of the formula ##STR1## is desired, in which R.sub.1 and R.sub.2 are identical or different and are a C.sub.2 - to C.sub.6 -alkyl radical or a phenyl radical, or R.sub.1 and R.sub.2 The process is carried out in the presence of a base in a diluent at a temperature of 0.degree. C. up to 100.degree. C. with isolation of the corresponding carboxylic acid succinimidyl ester.
摘要翻译: 需要通过N-羟基琥珀酰亚胺与羧酸和式I的卤代磷酸酯反应来制备羧酸琥珀酰亚胺酯的方法,其中R1和R2相同或不同,为C2- C 6 - 烷基或苯基,或R 1和R 2。该方法在碱存在下,在稀释剂中,在0℃至100℃的温度下进行,分离相应的羧酸琥珀酰亚胺酯 。
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公开(公告)号:US5939580A
公开(公告)日:1999-08-17
申请号:US976089
申请日:1997-11-21
申请人: Engelbert Kloimstein , Wolfram Hendel , Klaus Reiter , Christian Burger , Antonia Praus , Karl Heinz Giselbrecht , Eduard Perndorfer
发明人: Engelbert Kloimstein , Wolfram Hendel , Klaus Reiter , Christian Burger , Antonia Praus , Karl Heinz Giselbrecht , Eduard Perndorfer
IPC分类号: C07C67/313 , C07C67/333 , C07C67/52 , C07C67/56 , C07C67/60 , C07C69/67 , C07C69/675 , C07C69/716 , C07C69/66
CPC分类号: C07C67/333
摘要: Process for preparing glyoxylic esters or their hydrates in which a water-soluble salt of a maleic or fumaric monoester or a mixture thereof is reacted with ozone in aqueous solution at temperatures of from 0 to 50.degree. C., and the corresponding glyoxylic ester or its hydrate is isolated from the resulting reaction mixture.
摘要翻译: 制备乙醛酸酯或其水合物的方法,其中马来酸或富马酸单酯的水溶性盐或其混合物在0〜50℃的温度下与臭氧在水溶液中反应,并且相应的乙醛酸酯或其 从所得反应混合物中分离出水合物。
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