公开(公告)号：US09216943B2

公开(公告)日：2015-12-22

申请号：US14114305

申请日：2012-04-27

Applicant: Srinivas Katkam ,  Rajeswar Reddy Sagyam ,  Raghavendar Rao Morthala ,  Babu Ireni ,  Krishna Vinigari ,  Suresh Kumar Ramdoss ,  Srinivasulu Rangineni ,  Arjunkumar Tummala ,  Javed Iqbal ,  Srinivas Oruganti ,  Bhaskar Kandagatla

Inventor： Srinivas Katkam ,  Rajeswar Reddy Sagyam ,  Raghavendar Rao Morthala ,  Babu Ireni ,  Krishna Vinigari ,  Suresh Kumar Ramdoss ,  Srinivasulu Rangineni ,  Arjunkumar Tummala ,  Javed Iqbal ,  Srinivas Oruganti ,  Bhaskar Kandagatla

IPC: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/02 ,  C07C215/28 ,  C07C213/00 ,  C07C213/10

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

Abstract: The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.

Abstract translation: 本申请提供了芬戈莫德及其药学上可接受的盐的制备方法，盐酸芬戈莫德的纯化方法和用于制备无定形芬戈莫德盐酸盐的方法。

公开(公告)号：US20140235895A1

公开(公告)日：2014-08-21

申请号：US14114305

申请日：2012-04-27

Applicant: Srinivas Katkam ,  Rajeswar Reddy Sagyam ,  Raghavendar Rao Morthala ,  Babu Ireni ,  Krishna Vinigari ,  Suresh Kumar Ramdoss ,  Srinivasulu Rangineni ,  Arjunkumar Tummala ,  Javed Iqbal ,  Srinivas Oruganti ,  Bhaskar Kandagatla

Inventor： Srinivas Katkam ,  Rajeswar Reddy Sagyam ,  Raghavendar Rao Morthala ,  Babu Ireni ,  Krishna Vinigari ,  Suresh Kumar Ramdoss ,  Srinivasulu Rangineni ,  Arjunkumar Tummala ,  Javed Iqbal ,  Srinivas Oruganti ,  Bhaskar Kandagatla

IPC: C07C205/45 ,  C07C213/10 ,  C07C215/28 ,  C07C213/00

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

Abstract: The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.

Abstract translation: 本申请提供了芬戈莫德及其药学上可接受的盐的制备方法，盐酸芬戈莫德的纯化方法和用于制备无定形芬戈莫德盐酸盐的方法。

公开(公告)号：US20110028518A1

公开(公告)日：2011-02-03

申请号：US12921873

申请日：2009-03-18

Applicant: Naveen Kumar Kolla ,  Nagaraju Manne ,  Srinivas Gangula ,  Udaykumar Neelam ,  Anitha Naredla ,  Sudhakar Reddy Baddam ,  Sumeet Vishwasrao Patil ,  Arjunkumar Tummala ,  Subbareddy Peddireddy ,  Sachin Gulabrao Shinde ,  Ashok Sigala ,  Satish Varma Mudunuru ,  Madhu Kiran Tummidi

Inventor： Naveen Kumar Kolla ,  Nagaraju Manne ,  Srinivas Gangula ,  Udaykumar Neelam ,  Anitha Naredla ,  Sudhakar Reddy Baddam ,  Sumeet Vishwasrao Patil ,  Arjunkumar Tummala ,  Subbareddy Peddireddy ,  Sachin Gulabrao Shinde ,  Ashok Sigala ,  Satish Varma Mudunuru ,  Madhu Kiran Tummidi

IPC: A61K31/4439 ,  C07D401/12 ,  A61P1/04

CPC classification number: C07D401/12 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/6951 ,  B82Y5/00

Abstract: Processes for the preparation of dexlansoprazole, an amorphous form of dexlansoprazole, a solid dispersion of amorphous dexlansoprazole and a pharmaceutically acceptable carrier, and processes for their preparation. Also provided are crystalline compounds 2-[(R)-[(4-chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and 2-[(R)-[(4-nitro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, and methods for their preparation.

Abstract translation: 右兰索拉唑，无效形式的右兰索拉唑，无定形右兰索拉唑的固体分散体和药学上可接受的载体的方法及其制备方法。 还提供了结晶化合物2 - [（R） - [（4-氯-3-甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑和2 - [（R） - [（4-硝基-3- 甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑及其制备方法。