公开(公告)号：US06696298B2

公开(公告)日：2004-02-24

申请号：US10012729

申请日：2001-12-07

申请人： Ronald M. Cook ,  Rand Dill ,  Arnie Baltzley

发明人： Ronald M. Cook ,  Rand Dill ,  Arnie Baltzley

IPC分类号： G01N110

CPC分类号： G01N35/1002 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/0036 ,  B01J2219/00389 ,  B01J2219/00414 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00722 ,  B01L3/0203 ,  C40B40/06 ,  C40B60/14 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/114165 ,  Y10T436/119163 ,  Y10T436/2575

摘要： Embodiments of the present invention are directed to an improved chemical synthesis apparatus for performing chemical synthesis such as nuclei acid synthesis in a plurality of reaction wells or cells in an efficient manner. The apparatus employs dispenser heads that each include a cluster of nozzles which are fluidicly coupled to a plurality of reagent sources for dispensing different reagents through the single dispenser head. Because each dispenser head is capable of dispensing a plurality of different reagents, the apparatus can perform simultaneous synthesis in a plurality of cells at a high throughput without complex and elaborate control of movement of the dispenser heads relative to the cells.

摘要翻译： 本发明的实施方案涉及一种用于在多个反应孔或细胞中以有效的方式进行化学合成如核酸合成的改进的化学合成装置。 该设备使用分配器头，每个分配器头包括一组喷嘴，其流体耦合到多个试剂源，用于通过单个分配头分配不同的试剂。 因为每个分配器头部能够分配多个不同的试剂，所以该设备可以以高通量在多个单元中执行同时合成，而无需对分配器头相对于单元的运动进行复杂和精细的控制。