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8 条记录 (耗时 0.016 秒)

    Novel urea derivatives and their medical use
    1.
    发明申请
    Novel urea derivatives and their medical use 审中-公开
    新型尿素衍生物及其医疗用途

    公开(公告)号：US20070142450A1

    公开(公告)日：2007-06-21

    申请号：US10590104

    申请日：2005-03-16

    申请人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

    发明人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

    IPC分类号： A61K31/4015 ,  A61K31/40 ,  C07D207/40 ,  C07D207/04

    CPC分类号： C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07D207/04 ,  C07D207/40

    摘要： This invention relates to novel urea derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的尿素衍生物，其被发现是烟碱乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Diphenylurea derivatives and their use as chloride channel blockers
    3.
    发明申请
    Diphenylurea derivatives and their use as chloride channel blockers 失效
    二苯基脲衍生物及其作为氯通道阻断剂的用途

    公开(公告)号：US20060178413A1

    公开(公告)日：2006-08-10

    申请号：US10561189

    申请日：2004-06-15

    申请人： Bjarne Dahl ,  Palle Christophersen

    发明人： Bjarne Dahl ,  Palle Christophersen

    IPC分类号： C07D257/02 ,  A61K31/41

    CPC分类号： C07D257/04

    摘要： The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical compositions comprising the compounds of the invention.

    摘要翻译： 本发明涉及可用作氯化物通道阻断剂的新型二苯基脲衍生物。 在其他方面，本发明涉及这些化合物在治疗方法中的用途，以及包含本发明化合物的药物组合物。

    Diphenylurea Derivatives Useful As Potassium Channel Activators
    7.
    发明申请
    Diphenylurea Derivatives Useful As Potassium Channel Activators 审中-公开
    用作钾通道活化剂的二苯基脲衍生物

    公开(公告)号：US20070293553A1

    公开(公告)日：2007-12-20

    申请号：US11791340

    申请日：2005-12-14

    申请人： Bjarne Dahl ,  Palle Christophersen ,  Joachim Demnitz

    发明人： Bjarne Dahl ,  Palle Christophersen ,  Joachim Demnitz

    IPC分类号： A61K31/41 ,  A61P11/00 ,  A61P13/00 ,  A61P25/00

    CPC分类号： A61K31/17 ,  A61K31/41

    摘要： The present invention relates to the medical use of a certain group of diphenyl urea derivatives as potassium channel blockers for treating cardiovascular diseases, an obstructive or inflammatory airway disease, urinary incontinence, psychosis, epilepsy or pain, or for facilitating the blood-brain barrier permeability for other therapeutic substances. In other aspects the invention relates to the use of these compounds in a method of therapy.

    摘要翻译： 本发明涉及一组二苯脲衍生物作为治疗心血管疾病，阻塞性或炎性气道疾病，尿失禁，精神病，癫痫或疼痛的钾通道阻滞剂或促进血脑屏障渗透性的医学用途 用于其他治疗物质。 在其它方面，本发明涉及这些化合物在治疗方法中的用途。

    Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy
    8.
    发明申请
    Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy 审中-公开
    可用于治疗抗血管发生治疗的疾病的化合物

    公开(公告)号：US20060058395A1

    公开(公告)日：2006-03-16

    申请号：US10522258

    申请日：2003-07-31

    申请人： Jens Lichtenberg ,  Palle Christophersen ,  Bjarne Dahl

    发明人： Jens Lichtenberg ,  Palle Christophersen ,  Bjarne Dahl

    IPC分类号： A61K31/13

    CPC分类号： A61K31/41

    摘要： This invention relates to the use of certain compounds for the treatment of diseases that are responsive to antiangiogenetic therapy. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis and psoriasis. The compounds are particularly useful for anti-metastatic treatment or for the treatment of age-related macular degeneration.

    摘要翻译： 本发明涉及某些化合物用于治疗对抗血管发生治疗有反应的疾病的用途。 过多的血管生成发生在癌症，糖尿病性失明，年龄相关性黄斑变性，类风湿性关节炎和银屑病等疾病中。 该化合物特别可用于抗转移治疗或治疗年龄相关性黄斑变性。