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公开(公告)号：US20080090762A1
公开(公告)日：2008-04-17
申请号：US11704726
申请日：2007-02-09
申请人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
发明人： Kenneth Grabstein , Dirk Anderson , June Eisenman , Victor Fung , Charles Rauch
IPC分类号： A61K38/17 , A61P1/04 , A61P31/18 , C07H21/04 , C07K14/47 , C07K16/18 , C12N15/63 , C12N5/06 , C12N5/12 , C12P21/02
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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2.发明授权公开(公告)号：US07192935B1
公开(公告)日：2007-03-20
申请号：US09724841
申请日：2000-11-28
CPC分类号： C07K14/5443 , A61K38/00
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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公开(公告)号：US06555354B2
公开(公告)日：2003-04-29
申请号：US09726968
申请日：2000-11-29
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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4.发明授权Method for treating or preventing gastrointestinal disease with epithelium-derived T-cell factor 失效用上皮衍生的T细胞因子治疗或预防胃肠道疾病的方法
公开(公告)号：US5707616A
公开(公告)日：1998-01-13
申请号：US726817
申请日：1996-10-04
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性ETF的核酸序列，指导ETF表达的表达载体，ETF多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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公开(公告)号：US20080160571A1
公开(公告)日：2008-07-03
申请号：US11709436
申请日：2007-02-21
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US6072047A
公开(公告)日：2000-06-06
申请号：US883036
申请日：1997-06-26
申请人： Charles Rauch , Henning Walczak
发明人： Charles Rauch , Henning Walczak
IPC分类号： C12N15/09 , A61K38/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/08 , C07H21/04 , C12N15/63
CPC分类号： C07K16/2878 , C07K14/70578 , C07K14/715 , A61K38/00 , C07K2317/34
摘要： A protein designated TRAIL receptor binds the protein known as TNF-Related Apoptosis-Inducing Ligand (TRAIL). The TRAIL receptor finds use in purifying TRAIL or inhibiting activities thereof. Isolated DNA sequences encoding TRAIL-R polypeptides are provided, along with expression vectors containing the DNA sequences, and host cells transformed with such recombinant expression vectors. Antibodies that are immunoreactive with TRAIL-R are also provided.
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公开(公告)号：US20130020843A1
公开(公告)日：2013-01-24
申请号：US13358400
申请日：2012-01-25
CPC分类号： A47C5/005 , A47C9/00 , Y10T29/49815
摘要： A disposable and portable seating apparatus made from a single sheet of recyclable material, such as corrugated cardboard. The apparatus is intended to be used as temporary seating for events, festivals, gatherings, or similar situations where seating is not readily available, or practical. The structural component of the seating apparatus is designed to interlock providing optimal strength to support the weight of an average adult. The design and material allow the seating apparatus to be assembled and disassembled relatively easily, without the use of any tools or additional bonding agents, such as glue, staples, or other adhesives. After use, the seat can be turned upside down and serve as a recycling container, or trash receptacle for discarded materials, such as; cans, bottles, etc. The exterior of the assembled may act as a medium for advertising purposes, used by companies promoting products, events, contests, teams, or organizations.
摘要翻译： 由一片可回收材料制成的一次性便携式座椅装置，如瓦楞纸板。 该装置旨在用作临时座位用于事件，节日，聚会或类似情况，其中座位不容易获得或实用。 座椅装置的结构部件被设计成互锁提供最佳强度以支撑一般成人的重量。 设计和材料允许座椅装置相对容易地组装和拆卸，而不使用任何工具或附加的粘合剂，例如胶水，订书钉或其他粘合剂。 使用后，座椅可以颠倒倒转，作为回收容器，或废弃物的垃圾桶，如： 罐头，瓶子等。组装的外部可以作为广告目的的媒介，由促进产品，事件，比赛，团队或组织的公司使用。
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公开(公告)号：US20070063787A1
公开(公告)日：2007-03-22
申请号：US11523141
申请日：2006-09-19
申请人： Charles Rauch
发明人： Charles Rauch
IPC分类号： H01P5/10
CPC分类号： H01P5/10
摘要： The present antenna system includes a balun for coupling an antenna to a feed line. The balun has at least two transmission line transformers, such that the transmission line transformers are coupled in parallel at their inputs with the feedline, and coupled in series at their outputs with the antenna. At least one of the transmission line transformers maintained by the balun is fabricated so that it has reduced power dissipation properties, and reduced electromagnetic stress handling properties with respect to the other transmission line transformers. Such considerations reduce fabrication time, waste of material, and the cost of the balun.
摘要翻译： 本天线系统包括用于将天线耦合到馈线的平衡 - 不平衡变换器。 平衡 - 不平衡转换器具有至少两个传输线变压器，使得传输线变压器在其输入端与馈线并联耦合，并且在其输出端与天线串联耦合。 制造由平衡 - 不平衡变换器维持的传输线变压器中的至少一个，使得其相对于其它传输线变压器具有降低的功率耗散特性和降低的电磁应力处理性能。 这样的考虑减少了制造时间，材料的浪费和平衡 - 不平衡变换器的成本。
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公开(公告)号：US06406901B1
公开(公告)日：2002-06-18
申请号：US09579766
申请日：2000-05-26
IPC分类号： C12N950
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US5985262A
公开(公告)日：1999-11-16
申请号：US794524
申请日：1997-02-03
IPC分类号： A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K16/24 , C12N5/12 , C12N15/24
CPC分类号： A61K38/1709 , Y10S514/885
摘要： Nucleic acid sequences which encode biologically active EMF, expression vectors which direct the expression of ETF, ETE polypeptides, antibodies which specffically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
摘要翻译： 公开了编码生物活性EMF的核酸序列，指导ETF表达的表达载体，ETE多肽，特异性结合ETF的抗体及其制备方法。 还公开了治疗或预防胃肠道疾病和HIV或HIV相关疾病的方法。
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