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    MASTER MONITORING MECHANISM FOR A GEOGRAPHICAL DISTRIBUTED DATABASE
    1.
    发明申请
    MASTER MONITORING MECHANISM FOR A GEOGRAPHICAL DISTRIBUTED DATABASE 有权
    地理分布数据库的主监控机制

    公开(公告)号：US20110178985A1

    公开(公告)日：2011-07-21

    申请号：US13121561

    申请日：2009-09-30

    申请人： Marta San Martin Arribas ,  Jorge Nevado Jimenez ,  Dennis Henriksen

    发明人： Marta San Martin Arribas ,  Jorge Nevado Jimenez ,  Dennis Henriksen

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30584 ,  G06F17/30581

    摘要： The present invention faces the issue of data replication in different database nodes of a geographically distributed database wherein clients cannot always perform any database-related operation in the closest database node. Thus, the present invention provides for an enhanced distributed database system with a plurality of nodes, each node arranged for storing a replica of at least one partition of data, and a method of handling said distributed database system comprising the steps of: partitioning data to a number of partitions; replicating each partition into a number of replicas; for each partition, distributing the number of replicas amongst database nodes; activating more than one node; monitoring at each active node events of: latest updating of each replica, replica status, status of local resources in charge of each replica, and connectivity status of each replica; upon activation o deactivation of a node, determining which node is considered current master node for each partition in charge of current mast replica; for any request received in a node to read/write data, determining the current master node in charge of the current master replica, and routing said request to said current master node.

    摘要翻译： 本发明面临地理分布式数据库的不同数据库节点中数据复制的问题，其中客户端不能总是在最近的数据库节点中执行任何数据库相关的操作。 因此，本发明提供了一种具有多个节点的增强分布式数据库系统，每个节点被布置用于存储至少一个数据分区的副本，以及一种处理所述分布式数据库系统的方法，包括以下步骤：将数据分割成 一些分区; 将每个分区复制到多个副本中; 为每个分区分配数据库节点之间的副本数; 激活多个节点; 每个活动节点上的监视事件：每个副本的最新更新，副本状态，负责每个副本的本地资源的状态以及每个副本的连接状态; 在激活时o停止节点，确定哪个节点被认为是负责当前桅杆复制的每个分区的当前主节点; 对于在节点中接收到的用于读/写数据的请求，确定当前主节点负责当前主副本，并将所述请求路由到所述当前主节点。

    Master monitoring mechanism for a geographical distributed database
    7.
    发明授权
    Master monitoring mechanism for a geographical distributed database 有权
    地理分布式数据库的主监控机制

    公开(公告)号：US08375001B2

    公开(公告)日：2013-02-12

    申请号：US13121561

    申请日：2009-09-30

    申请人： Marta San Martin Arribas ,  Jorge Nevado Jimenez ,  Dennis Henriksen

    发明人： Marta San Martin Arribas ,  Jorge Nevado Jimenez ,  Dennis Henriksen

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30584 ,  G06F17/30581

    摘要： A distributed database system with a plurality of nodes is provided, each node storing a replica of at least one partition of data. A method of handling the distributed database system comprises: partitioning data into a number of partitions; replicating each partition into a number of replicas; for each partition, distributing the number of replicas amongst database nodes; activating more than one node; monitoring at each active node events of: latest updating of each replica, replica status, status of local resources in charge of each replica, and connectivity status of each replica; upon activation or deactivation of a node, determining which node is considered current master node for each partition in charge of current master replica; for any request received in a node to read/write data, determining the current master node in charge of the current master replica, and routing said request to said current master node.

    摘要翻译： 提供了具有多个节点的分布式数据库系统，每个节点存储至少一个数据分区的副本。 一种处理分布式数据库系统的方法包括：将数据分割成多个分区; 将每个分区复制到多个副本中; 为每个分区分配数据库节点之间的副本数; 激活多个节点; 每个活动节点上的监视事件：每个副本的最新更新，副本状态，负责每个副本的本地资源的状态以及每个副本的连接状态; 在节点的激活或去激活时，确定哪个节点被认为是负责当前主副本的每个分区的当前主节点; 对于在节点中接收到的用于读/写数据的请求，确定当前主节点负责当前主副本，并将所述请求路由到所述当前主节点。

    Distributed Master Election
    8.
    发明申请
    Distributed Master Election 有权
    分布式大选

    公开(公告)号：US20110188506A1

    公开(公告)日：2011-08-04

    申请号：US13122517

    申请日：2009-09-30

    申请人： Marta San Martin Arribas ,  Dennis Henriksen ,  Jorge Nevado Jimenez

    发明人： Marta San Martin Arribas ,  Dennis Henriksen ,  Jorge Nevado Jimenez

    IPC分类号： H04L12/56

    CPC分类号： H04L67/1095 ,  H04L67/1002 ,  H04L67/1008 ,  H04L67/101 ,  H04L67/1097

    摘要： A transmitting node in a telecommunications network, wherein data are distributed into one or more data storage groups (DSG), and wherein data related to a DSG is replicated into a plurality of data storage elements (DS) distributed along one or more nodes of the network. The transmitting node includes a network interface through which a bi-directional connection is established with a plurality of other nodes in a transport layer of the network, and from which messages are sent to the plurality of other nodes comprising an operational state matrix (OSM), which includes information held by the transmitting node about the operational state of the replicas of the DSs of each DSG. The transmitting node includes a memory for storing data. The transmitting node includes a processing unit which forms a list of the plurality of other nodes as having an answer pending of the node in the memory. The network interface receives an OSM from at least some of other nodes which are interpreted by the processing unit as answer messages from the list of the plurality of other nodes to the messages sent by the network interface, and which indicates that an OSM information exchange with the plurality of the other nodes is complete. The processing unit decides a node hosting the master DS replica of each DSG based on the OSM information exchange. The processing unit detects changes in a view of the world (VOW) which includes an accumulated set of OSMs with respect to each DSG hosted by the transmitting node. The network interface sends messages comprising changes in the VOW to the other nodes.

    摘要翻译： 电信网络中的发送节点，其中数据被分配到一个或多个数据存储组（DSG）中，并且其中与DSG相关的数据被复制到沿着所述数据存储组（DSG）的一个或多个节点分发的多个数据存储元件 网络。 发射节点包括网络接口，通过该网络与网络的传输层中的多个其他节点建立双向连接，并且从哪个消息发送到包括操作状态矩阵（OSM）的多个其他节点， ，其包括发送节点关于每个DSG的DS的副本的操作状态的信息。 发送节点包括用于存储数据的存储器。 发送节点包括处理单元，该处理单元将多个其他节点的列表形成为具有存储器中节点的待决答案。 网络接口从至少一些其他节点接收OSM，这些节点由处理单元解释为从多个其他节点的列表到由网络接口​​发送的消息的应答消息，并且其指示OSM信息与 多个其他节点是完整的。 处理单元基于OSM信息交换来决定承载每个DSG的主DS副本的节点。 处理单元检测世界视图（VOW）中的变化，其包括相对于由发送节点托管的每个DSG的累积的OSM集合。 网络接口将包含VOW中的更改的消息发送到其他节点。

    Enzymatic method for modification of recombinant polypeptides
    9.
    发明授权
    Enzymatic method for modification of recombinant polypeptides 失效
    用于修饰重组多肽的酶法

    公开(公告)号：US06403361B1

    公开(公告)日：2002-06-11

    申请号：US09505991

    申请日：2000-02-17

    申请人： Fred W. Wagner ,  Jay Stout ,  Dennis Henriksen ,  Bruce Partridge ,  Shane Manning

    发明人： Fred W. Wagner ,  Jay Stout ,  Dennis Henriksen ,  Bruce Partridge ,  Shane Manning

    IPC分类号： C12N120

    CPC分类号： C07K14/60 ,  A61K38/00 ,  C07K14/605 ,  C07K2319/00 ,  C12P21/02 ,  C12P21/06

    摘要： The method of the invention provides for the formation of a recombinant polypeptide which has been modified at the C-terminal end through the use of a transpeptidation process. The method is suitable for modifying recombinant polypeptides of any source including those which may be commercially available, those derived from recombinant single copy or multicopy polypeptide constructs, or those derived from single or multicopy recombinant fusion protein constructs. The transpeptidation reaction involves contacting an endopeptidase enzyme with a recombinant polypeptide to substitute an addition unit, of one or more amino acids, for a leaving unit, linked to a core polypeptide through a cleavage site recognized by the endopeptidase enzyme. Recombinant polypeptides derived from multicopy polypeptide constructs may be cleaved from the multicopy polypeptide at the N-terminal and C-terminal ends and simultaneously under go substitution of the leaving unit by the desired addition unit. The invention utilizes known and newly discovered cleavage recognition sites to effectuate the desired modification products.

    摘要翻译： 本发明的方法提供了通过使用转肽酶方法在C末端修饰的重组多肽的形成。 该方法适用于修饰任何来源的重组多肽，包括可商购的重组多肽，衍生自重组单拷贝或多拷贝多肽构建体的重组多肽，或衍生自单拷贝或多拷贝重组融合蛋白构建体的重组多肽。 转肽反应包括使内肽酶与重组多肽接触，以将一个或多个氨基酸的加成单元替换为通过内肽酶识别的切割位点与核心多肽连接的离去单元。 衍生自多拷贝多肽构建体的重组多肽可以在N末端和C-末端的多拷贝多肽中切割，同时在离去单位取代所需的加成单位。 本发明利用已知和新发现的裂解识别位点来实现所需的修饰产物。

    Process for the preparation of C-terminally amidated peptides
    10.
    发明授权
    Process for the preparation of C-terminally amidated peptides 失效
    制备C-末端酰胺化肽的方法

    公开(公告)号：US5580751A

    公开(公告)日：1996-12-03

    申请号：US431539

    申请日：1995-04-21

    申请人： Ole Buchardt ,  Klaus Breddam ,  Dennis Henriksen

    发明人： Ole Buchardt ,  Klaus Breddam ,  Dennis Henriksen

    IPC分类号： C07K1/00 ,  C12N9/48 ,  C12P21/02 ,  C12P21/06 ,  C12N9/76

    CPC分类号： C12N9/48 ,  C07K1/003 ,  C12P21/02

    摘要： A process for preparing C-terminally amidated peptides, Peptide-NH.sub.2, is presented. In a first step, a substrate component is reacted with a nucleophile component in the presence of trypsin or a carboxypeptidase using as nucleophile a compound NH.sub.2 -R to form a first reaction product Peptide-NH-R. In a second step, the first reaction product is non-enzymatically chemically cleaved to form the C-terminally amidated product, Peptide-NH.sub.2. The substrate component is selected from a) peptide derivatives Peptide-X-Y, where X is an amino acid or peptide residue and Y is OH, OMe or C-terminal modification and c) C-terminally esterified peptides, Peptide-OR', where R' is alkyl, aryl, heteroaryl, or aralkyl. The nucleophile component is selected from ##STR1## wherein A-F and A'-E' are carbon atoms or up to two hetero atoms, Y is H, alkyl, aryl, aralkyl, oxo or carboxy, X.sup.1 -X.sup.5 are H or various substituents. The cleavage may be induced by photolysis, solvolysis, reduction, rearrangement elimination, or oxidation. The process may be adapted to enzymatic synthesis and lends itself to C-terminal amidation of many types of peptides.

    摘要翻译： 提出了一种制备C末端酰胺化肽肽肽-NH2的方法。 在第一步中，在胰蛋白酶或羧肽酶存在下，使底物成分与亲核成分反应，使用化合物NH2-R作为亲核试剂，形成第一反应产物肽-NH-R。 在第二步中，第一反应产物是非酶学化学裂解以形成C末端酰胺化产物肽-NH 2。 底物组分选自a）肽衍生物P-XY，其中X是氨基酸或肽残基，Y是OH，OMe或C末端修饰，和c）C末端酯化肽，肽-OR'，其中R '是烷基，芳基，杂芳基或芳烷基。 亲核成分选自其中A-F和A'-E'是碳原子或至多两个杂原子，Y是H，烷基，芳基，芳烷基，氧代或羧基，X 1 -X 5是H或各种取代基。 裂解可以通过光解，溶剂分解，还原，重排排除或氧化来诱导。 该方法可适用于酶合成，并适用于许多类型肽的C-末端酰胺化。