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    Diagnosis of P. aeruginosa infection in the lungs of patients
    3.
    发明授权
    Diagnosis of P. aeruginosa infection in the lungs of patients 有权
    诊断患者肺部铜绿假单胞菌感染

    公开(公告)号：US07717857B2

    公开(公告)日：2010-05-18

    申请号：US12150199

    申请日：2008-04-25

    Applicant: Graham Timmins ,  Vojo P. Deretic

    Inventor： Graham Timmins ,  Vojo P. Deretic

    IPC: A61B5/08

    CPC classification number: C12Q1/04 ,  A61K51/04 ,  A61K51/0406 ,  A61K51/1206 ,  G01N33/497 ,  G01N2333/21

    Abstract: The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.

    Abstract translation: 本发明涉及用于检测铜绿假单胞菌感染风险的患者肺部铜绿假单胞菌感染和细菌负担的方法，特别是包括囊性纤维化（CF）患者。 本方法提供了许多试验（呼吸，血液，尿液），其易于对患者施用，其将敏感且特异性地检测肺部感染铜绿假单胞菌（粘液样和非粘液样）的存在和程度，并允许监测细菌 负载作为监测治疗的参数。

    MAGNETODYNAMIC ACTIVATION OF 13C-ACYL ISONIAZID AND ISONIAZID AND ETHIONAMIDE DERIVATIVES
    5.
    发明申请
    MAGNETODYNAMIC ACTIVATION OF 13C-ACYL ISONIAZID AND ISONIAZID AND ETHIONAMIDE DERIVATIVES 有权
    13C-ACYL异亮氨酸和异亮氨酸和酰胺衍生物的磁活性激活

    公开(公告)号：US20150246126A1

    公开(公告)日：2015-09-03

    申请号：US14426543

    申请日：2013-09-06

    Applicant: Graham TIMMINS ,  Seong Won CHOI ,  STC.UNM

    Inventor： Graham Timmins ,  Seong Won Choi

    IPC: A61K41/00 ,  A61K31/4409

    CPC classification number: A61K41/0052 ,  A61K31/4409

    Abstract: The invention provides method of treating a subject suffering from, or at risk of developing, a Mycobacterium infection by administering to the subject a therapeutically-effective amount of isotopically labeled isoniazid and/or ethionamide, or an analog, derivative or prodrug thereof, and exposing the subject to a magnetic field.

    Abstract translation: 本发明提供了通过向受试者施用治疗有效量的同位素标记的异烟肼和/或乙硫异烟胺或其类似物，衍生物或前药，以及暴露于受试者的方法，治疗患有或有发展为分枝杆菌感染风险的受试者 受到磁场的影响。

    Diagnosis of infection in the lungs of patients
    6.
    再颁专利
    Diagnosis of infection in the lungs of patients 有权
    诊断患者肺部感染

    公开(公告)号：USRE44533E1

    公开(公告)日：2013-10-08

    申请号：US13467514

    申请日：2012-05-09

    Applicant: Graham Timmins ,  Vojo P. Deretic

    Inventor： Graham Timmins ,  Vojo P. Deretic

    IPC: A61B5/08

    CPC classification number: C12Q1/04 ,  A61K51/04 ,  A61K51/0406 ,  A61K51/1206 ,  G01N33/497 ,  G01N2333/21

    Abstract: The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.

    Abstract translation: 本发明涉及用于检测铜绿假单胞菌感染风险的患者肺部铜绿假单胞菌感染和细菌负担的方法，特别是包括囊性纤维化（CF）患者。 本方法提供了许多试验（呼吸，血液，尿液），其易于对患者施用，其将敏感且特异性地检测肺部感染铜绿假单胞菌（粘液样和非粘液样）的存在和程度，并允许监测细菌 负载作为监测治疗的参数。

    SYSTEM AND METHODS OF MELANOMA PREVENTION
    7.
    发明申请
    SYSTEM AND METHODS OF MELANOMA PREVENTION 审中-公开
    梅兰病预防系统与方法

    公开(公告)号：US20110021623A1

    公开(公告)日：2011-01-27

    申请号：US12895227

    申请日：2010-09-30

    Applicant: Graham TIMMINS ,  Leslie Paige Lund

    Inventor： Graham TIMMINS ,  Leslie Paige Lund

    IPC: A61K31/351 ,  A61K31/235 ,  A61K31/17

    CPC classification number: A61K31/351 ,  A61K8/37 ,  A61K8/46 ,  A61K8/498 ,  A61K2800/782 ,  A61K2800/92 ,  A61Q17/04

    Abstract: Inhibiting the enzymic action of tyrosinase in the melanocyte prior to, during, or after ultraviolet (UV) radiation exposure, including over-exposure causing erythema, or sunburn, prevents the production of melanin and thereby melanoma. Melanoma can be prevented by using a tyrosinase inhibitor agent that inhibits the enzymic action of tyrosinase to prevent damage and/or death of melanocytes. The inhibitor agent can be applied to the skin or ingested.

    Abstract translation: 在紫外线（UV）辐射暴露（包括过度暴露引起红斑或晒伤）之前，期间或之后，在黑素细胞中抑制酪氨酸酶的酶作用可以防止黑色素和黑色素瘤的产生。 可以通过使用抑制酪氨酸酶的酶作用以防止黑素细胞的损伤和/或死亡的酪氨酸酶抑制剂来防止黑素瘤。 抑制剂可以施用于皮肤或摄取。

    Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke
    10.
    发明申请
    Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke 审中-公开
    血液生物标志物用于缺血性脑卒中早期血脑屏障中断

    公开(公告)号：US20150198617A1

    公开(公告)日：2015-07-16

    申请号：US14677053

    申请日：2015-04-02

    Applicant: Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

    Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

    IPC: G01N33/68

    CPC classification number: G01N33/6893 ,  G01N2333/4703 ,  G01N2800/2871 ,  G01N2800/52

    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

    Abstract translation: 提供了用于确定血脑屏障（BBB）损伤并治疗可能由于缺血事件而遭受BBB损伤的患者的方法和装置。 所述方法和装置涉及检测血液样品中裂解的闭合蛋白片段的存在。 根据一些实施方案，该方法进一步提供基于样品中闭合蛋白片段的浓度确定BBB损伤的程度。 在进一步的实施方案中，本公开提供用于检测血液样品中闭合蛋白片段的存在的试剂盒。

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