公开(公告)号：US08962692B2

公开(公告)日：2015-02-24

申请号：US13465383

申请日：2012-05-07

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: A61K31/095 ,  A61K31/105 ,  C07C323/03 ,  C07C323/64 ,  C07C327/34 ,  C07C323/60 ,  C07D241/08 ,  C07D487/04 ,  C07K5/062

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明公开了具有以下通式的半胱氨酸前药：具有以下通式的半胱氨酸前药的胱氨酸二聚体：具有以下通式的保护半胱氨酸类似物：具有以下通式的受保护的半胱氨酸类似物的二聚体：本发明还包括含有 公开的前药，二聚体和类似物，以及使用这些化合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US08435997B2

公开(公告)日：2013-05-07

申请号：US12897353

申请日：2010-10-04

Applicant: James M. Cook ,  Edward Merle Johnson, II ,  David A. Baker ,  Wenyuan Yin

Inventor： James M. Cook ,  Edward Merle Johnson, II ,  David A. Baker ,  Wenyuan Yin

IPC: A61K31/497

CPC classification number: C07D241/08

Abstract: The present invention provides cysteine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US08268854B2

公开(公告)日：2012-09-18

申请号：US12471019

申请日：2009-05-22

Applicant: James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

Inventor： James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

IPC: C07D471/12 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.

Abstract translation: 提供具有根据式（I）的一般结构的化合物：还提供包含这些化合物的药物组合物。 本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。

公开(公告)号：US08173809B2

公开(公告)日：2012-05-08

申请号：US12367867

申请日：2009-02-09

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: C07D295/00

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction. Exemplary prodrugs include the cysteine compound having the formula as well as cystine dimers thereof.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。 示例性的前药包括具有下式的半胱氨酸化合物及其胱氨酸二聚体。

公开(公告)号：US20100130481A1

公开(公告)日：2010-05-27

申请号：US12684845

申请日：2010-01-08

Applicant: James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioeyan Li ,  Jianming Yu ,  Dongmel Han

Inventor： James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioeyan Li ,  Jianming Yu ,  Dongmel Han

IPC: A61K31/551 ,  A61P25/22

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.

Abstract translation: 公开了使用口服活性苯并二氮杂衍生物及其盐的方法。 这些化合物及其盐具有降低镇静，催眠，肌肉松弛剂或共济失调作用的抗惊厥和抗焦虑活性。

公开(公告)号：US20090306121A1

公开(公告)日：2009-12-10

申请号：US12471019

申请日：2009-05-22

Applicant: James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

Inventor： James M. Cook ,  Michael L. Van Linn ,  Wenyuan Yin

IPC: A61K31/4375 ,  C07D471/14 ,  A61P25/32

CPC classification number: C07D471/04

Abstract: Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides methods of treating alcoholism, methods of reducing alcohol intake, methods of treating anhedonia, and methods of treating anxiety using theses compounds or the compositions containing them.

Abstract translation: 提供具有根据式（I）的一般结构的化合物：还提供包含这些化合物的药物组合物。 本发明还提供了使用这些化合物或含有它们的组合物治疗酒精中毒的方法，降低酒精摄取的方法，治疗焦虑的治疗方法和治疗焦虑症的方法。

公开(公告)号：US07618958B2

公开(公告)日：2009-11-17

申请号：US11173981

申请日：2005-06-30

Applicant: James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V. Srirama Sarma ,  Chunchun Zhang

Inventor： James M. Cook ,  Hao Zhou ,  Shengming Huang ,  P.V.V. Srirama Sarma ,  Chunchun Zhang

IPC: A61P25/22 ,  A61K31/5513 ,  C07D243/14 ,  C07D243/18 ,  C07D487/04 ,  C07D495/04 ,  C07D495/14

CPC classification number: C07D243/24 ,  C07D243/16 ,  C07D471/06 ,  C07D487/04 ,  C07D487/06

Abstract: The present invention provides compositions and methods of using stereospecific benzodiazepine derivatives, their salts and prodrugs for the treatment of anxiolytic or convulsant disorders having the side effects of reduced alcohol craving in human alcoholics and a concomitant reduced sedative, hypnotic, muscle relaxant and ataxic side-effects. The invention further provides pharmaceutical compositions for treatment of anxiolytic and convulsant disorders in subjects in need thereof, comprising a compound, prodrug or a salt having a chemical structure represented by any one of Formula I-XXI and a pharmaceutically-acceptable carrier.

Abstract translation: 本发明提供了使用立体定向苯并二氮杂衍生物，其盐和前药用于治疗在人类酒精中具有降低酒精渴求的副作用的抗焦虑或惊厥疾病的组合物和方法，以及伴随的降低镇静剂，催眠药，肌肉松弛剂和共济失调副作用的组合物和方法， 效果。 本发明还提供用于治疗有需要的受试者的抗焦虑和惊厥疾病的药物组合物，其包含具有由式I-XXI中任一项所示的化学结构和药学上可接受的载体的化合物，前药或盐。

公开(公告)号：US20090281109A1

公开(公告)日：2009-11-12

申请号：US12367867

申请日：2009-02-09

Applicant: James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

Inventor： James M. Cook ,  David A. Baker ,  Wenyuan Yin ,  Edward Merle Johnson, II

IPC: A61K31/497 ,  C07D241/08 ,  C07D241/36 ,  C07D241/04 ,  A61K31/4965 ,  C07C69/003 ,  A61K31/215 ,  A61K31/225 ,  A61P25/18 ,  A61P25/30

CPC classification number: C07D241/08 ,  A61K9/0053 ,  C07C323/60 ,  C07C327/34 ,  C07D211/86 ,  C07D487/04 ,  C07K5/0606

Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.

Abstract translation: 本发明提供了用于治疗精神分裂症和药物成瘾的半胱氨酸和胱氨酸前药。 本发明还包括含有药物组合物的药物组合物和使用前药和组合物治疗精神分裂症和药物成瘾的方法。

公开(公告)号：US07119196B2

公开(公告)日：2006-10-10

申请号：US10402538

申请日：2003-03-28

Applicant: James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han ,  Snjezana Lelas ,  John F. McElroy

Inventor： James M. Cook ,  Qi Huang ,  Xiaohui He ,  Xioayan Li ,  Jianming Yu ,  Dongmei Han ,  Snjezana Lelas ,  John F. McElroy

IPC: C07D487/12

CPC classification number: C07D471/04 ,  C07D243/12 ,  C07D243/20 ,  C07D243/24 ,  C07D487/04 ,  C07D487/06 ,  C07D495/04 ,  C07D495/14 ,  C07D498/04 ,  C07D519/00

Abstract: Orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anxiolytic and anticonvulsant activity with reduced sedative/hypnotic/muscle relaxant/ataxic effects.

Abstract translation: 公开了口服活性苯二氮卓衍生物及其盐。 这些化合物及其盐具有抗焦虑和抗惊厥活性，降低镇静/催眠/肌肉松弛/共济失调作用。

公开(公告)号：US3948190A

公开(公告)日：1976-04-06

申请号：US512140

申请日：1974-10-04

Applicant: James M. Cook, III ,  Edward K. Tazzia

Inventor： James M. Cook, III ,  Edward K. Tazzia

IPC: B65D19/00 ,  B65D19/44 ,  B65D19/24

CPC classification number: B65D19/004 ,  B65D19/44 ,  B65D2519/00034 ,  B65D2519/00069 ,  B65D2519/00268 ,  B65D2519/00288 ,  B65D2519/00318 ,  B65D2519/00333 ,  B65D2519/00338 ,  B65D2519/00407 ,  B65D2519/0094

Abstract: An industrial load-carrying pallet comprising an integral sheet of material formed with strengthening ribs extending thereacross, three centrally disposed pedestals extending downwardly at the center line and generally W-shaped pedestals disposed adjacent the side extremities. Grooves extend downwardly from the upper surface and are disposed along the circumference of four circles for receiving the bottom rims of four drums. The pedestals have recesses therein disposed on the circumference of four circles whereby the pedestals may rest upon and engage the top rims of four drums. The area of the top surface within each circle for receiving the bottom rim of a drum is spherically concave. The side pedestals have spaced converging walls in a downward direction which are joined at the lower extremities by a bottom base. Empty pallets may be stacked by placing the pedestals within one another. However, there is included anti-locking means in the form of shoulders extending inwardly from the side walls of the side pedestals to engage bottom base of a like pedestal of another pallet to prevent stacked pallets from being wedged into binding engagement with one another.

Abstract translation: 一种工业承载托盘，其包括整体的材料片材，其形成有在其上延伸的加强肋，在中心线向下延伸的三个中心布置的基座以及邻近所述侧端布置的大体上为W形的基座。 槽从上表面向下延伸，并且沿着四个圆的圆周设置以接收四个鼓的底部边缘。 基座在四个圆周的圆周上具有凹槽，由此基座可以搁置在四个滚筒的顶部边缘上并与其接合。 用于接收鼓的底部边缘的每个圆中的顶部表面的面积是球形的。 侧基座具有向下方向的间隔的会聚壁，其在下端通过底部底座连接。 可以通过将基座放置在彼此中来堆叠空托盘。 然而，包括从侧座的侧壁向内延伸的肩部形式的防抱死装置，以接合另一个托盘的类似基座的底部基座，以防止堆叠的托盘楔入彼此的结合接合。