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公开(公告)号：US20180335385A1
公开(公告)日：2018-11-22
申请号：US15902759
申请日：2018-02-22
申请人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
发明人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
IPC分类号： G01N21/64 , G01N21/75 , G01N33/84 , C08F8/00 , A61B5/145 , G01N33/58 , A61K49/00 , A61B5/1455 , C08F293/00
CPC分类号： G01N21/6486 , A61B5/14539 , A61B5/1455 , A61K49/0021 , A61K49/0082 , A61K49/0093 , C08F8/00 , G01N21/75 , G01N33/582 , G01N33/84 , C08F293/005
摘要： Fluorescence methods and systems that use an optical agent for measuring the pH of a fluid. The optical agent is a photonic nanostructure having a supramolecular structure, such as a shell cross-linked micelle that incorporates at least one linking group that includes one or more photoactive moieties.
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2.发明授权Self-assembled structures, method of manufacture thereof and articles comprising the same 有权自组装结构，其制造方法和包含该组合结构的制品公开(公告)号：US08822130B2
公开(公告)日：2014-09-02
申请号：US13681019
申请日：2012-11-19
CPC分类号： G03F7/2004 , C08F2438/03 , C08G2261/126 , C08G2261/136 , C08G2261/146 , G03F7/0046 , G03F7/038 , G03F7/0382 , G03F7/40
摘要： Disclosed herein is a composition comprising a graft block copolymer comprising a first block polymer; the first block polymer comprising a backbone polymer and a first graft polymer; where the first graft polymer comprises a surface energy reducing moiety; and a second block polymer; the second block polymer being covalently bonded to the first block; wherein the second block comprises the backbone polymer and a second graft polymer; where the second graft polymer comprises a functional group that is operative to crosslink the graft block copolymer; a photoacid generator; and a crosslinking agent.
摘要翻译： 本文公开了包含含有第一嵌段聚合物的接枝嵌段共聚物的组合物; 所述第一嵌段聚合物包含主链聚合物和第一接枝聚合物; 其中第一接枝聚合物包含表面能减少部分; 和第二嵌段聚合物; 第二嵌段聚合物共价键合到第一嵌段; 其中所述第二嵌段包含主链聚合物和第二接枝聚合物; 其中第二接枝聚合物包含可操作地交联接枝嵌段共聚物的官能团; 光致酸发生器; 和交联剂。
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3.发明申请SELF-ASSEMBLED STRUCTURES, METHOD OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME 审中-公开自组装结构，其制造方法和包含其的文章公开(公告)号：US20140142252A1
公开(公告)日：2014-05-22
申请号：US13681012
申请日：2012-11-19
IPC分类号： C08F287/00
CPC分类号： C08F287/00 , C08F283/14 , C08F2438/03 , C08G61/08 , C08G2261/126 , C08G2261/128 , C08G2261/135 , C08G2261/136 , C08G2261/1426 , C08G2261/3324 , C08G2261/418 , C08G2261/74 , C08G2261/76 , C08G2261/77
摘要： Disclosed herein is a copolymer comprising a backbone polymer; and a first graft polymer that comprises a surface energy reducing moiety; the first graft polymer being grafted onto the backbone polymer; where the surface energy reducing moiety comprises a fluorine atom, a silicon atom, or a combination of a fluorine atom and a silicon atom.
摘要翻译： 本文公开了包含主链聚合物的共聚物; 和包含表面能减少部分的第一接枝聚合物; 第一接枝聚合物被接枝到主链聚合物上; 其中表面能减少部分包含氟原子，硅原子或氟原子和硅原子的组合。
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4.发明申请公开(公告)号：US20140141375A1
公开(公告)日：2014-05-22
申请号：US13681026
申请日：2012-11-19
CPC分类号： G03F7/0382 , G03F7/0042 , G03F7/0045 , G03F7/0046 , G03F7/0048 , G03F7/038 , G03F7/0387 , G03F7/075 , G03F7/0757 , G03F7/168
摘要： Disclosed herein is a composition comprising a graft block copolymer comprising a copolymer comprising a backbone polymer; and a first graft polymer that comprises a surface energy reducing moiety; the first graft polymer being grafted onto the backbone polymer; where the surface energy reducing moiety comprises a fluorine atom, a silicon atom, or a combination of a fluorine atom and a silicon atom; a photoacid generator; and a crosslinking agent.
摘要翻译： 本文公开了包含含有包含主链聚合物的共聚物的接枝嵌段共聚物的组合物; 和包含表面能减少部分的第一接枝聚合物; 第一接枝聚合物被接枝到主链聚合物上; 其中表面能减少部分包含氟原子，硅原子或氟原子和硅原子的组合; 光致酸发生器; 和交联剂。
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5.发明授权Functional, cross-linked nanostructures for tandem optical imaging and therapy 有权用于串联光学成像和治疗的功能性交联纳米结构公开(公告)号：US09295650B2
公开(公告)日：2016-03-29
申请号：US13697149
申请日：2011-11-17
申请人： William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Yun Lin , Guorong Sun
发明人： William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Yun Lin , Guorong Sun
IPC分类号： A61K49/00 , A61K9/14 , A61K9/00 , A61K9/107 , A61K9/51 , A61K31/20 , A61K31/70 , A61K38/16 , A61K38/22 , A61K39/395 , A61M5/00
CPC分类号： A61K41/0057 , A61K9/0092 , A61K9/1075 , A61K9/146 , A61K9/5138 , A61K9/5192 , A61K31/20 , A61K31/337 , A61K31/351 , A61K31/70 , A61K31/704 , A61K38/08 , A61K38/16 , A61K38/22 , A61K45/06 , A61K47/6911 , A61K49/0021 , A61K49/0054 , A61K49/0082 , A61K49/0093 , A61M5/007 , A61K2300/00
摘要： The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
摘要翻译： 本发明提供包含光学功能交联的超分子结构和用于串联光学成像和治疗的组合物的光学剂。 本发明的超分子结构和组件包括光学功能的壳交联胶束，其中通过引入一个或多个包含一个或多个光活性部分的连接基团来实现光学官能团。 本发明还包括使用本发明的一种或多种光学剂的成像和治疗方法，其包括具有相关治疗剂的光学功能性壳交联胶束。
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公开(公告)号：US20190302026A1
公开(公告)日：2019-10-03
申请号：US16381988
申请日：2019-04-11
申请人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
发明人： Karen L. Wooley , Richard B. Dorshow , John N. Freskos , William L. Neumann , Jeng J. Shieh , Nam S. Lee , Yun Lin , Guorong Sun
IPC分类号： G01N21/64 , G01N21/75 , G01N33/84 , G01N33/58 , C08F8/00 , A61B5/145 , A61K49/00 , A61B5/1455
摘要： Fluorescence methods and systems that use an optical agent for measuring the pH of a fluid. The optical agent is a photonic nanostructure having a supramolecular structure, such as a shell cross-linked micelle that incorporates at least one linking group that includes one or more photoactive moieties.
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7.发明申请公开(公告)号：US20140141376A1
公开(公告)日：2014-05-22
申请号：US13681019
申请日：2012-11-19
IPC分类号： G03F7/004
CPC分类号： G03F7/2004 , C08F2438/03 , C08G2261/126 , C08G2261/136 , C08G2261/146 , G03F7/0046 , G03F7/038 , G03F7/0382 , G03F7/40
摘要： Disclosed herein is a composition comprising a graft block copolymer comprising a first block polymer; the first block polymer comprising a backbone polymer and a first graft polymer; where the first graft polymer comprises a surface energy reducing moiety; and a second block polymer; the second block polymer being covalently bonded to the first block; wherein the second block comprises the backbone polymer and a second graft polymer; where the second graft polymer comprises a functional group that is operative to crosslink the graft block copolymer; a photoacid generator; and a crosslinking agent.
摘要翻译： 本文公开了包含含有第一嵌段聚合物的接枝嵌段共聚物的组合物; 所述第一嵌段聚合物包含主链聚合物和第一接枝聚合物; 其中第一接枝聚合物包含表面能减少部分; 和第二嵌段聚合物; 第二嵌段聚合物共价键合到第一嵌段; 其中所述第二嵌段包含主链聚合物和第二接枝聚合物; 其中第二接枝聚合物包含可操作地交联接枝嵌段共聚物的官能团; 光致酸发生器; 和交联剂。
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8.发明申请Functional, Cross-Linked Nanostructures for Tandem Optical Imaging and Therapy 有权功能，交联纳米结构的串联光学成像和治疗公开(公告)号：US20130137976A1
公开(公告)日：2013-05-30
申请号：US13697149
申请日：2011-11-17
申请人： William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Lily Nun Lin , Guorong Sun
发明人： William L. Neumann , Richard B. Dorshow , John N. Freskos , Karen L. Wooley , Nam S. Lee , Lily Nun Lin , Guorong Sun
CPC分类号： A61K41/0057 , A61K9/0092 , A61K9/1075 , A61K9/146 , A61K9/5138 , A61K9/5192 , A61K31/20 , A61K31/337 , A61K31/351 , A61K31/70 , A61K31/704 , A61K38/08 , A61K38/16 , A61K38/22 , A61K45/06 , A61K47/6911 , A61K49/0021 , A61K49/0054 , A61K49/0082 , A61K49/0093 , A61M5/007 , A61K2300/00
摘要： The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
摘要翻译： 本发明提供包含光学功能交联的超分子结构和用于串联光学成像和治疗的组合物的光学剂。 本发明的超分子结构和组件包括光学功能的壳交联胶束，其中通过引入一个或多个包含一个或多个光活性部分的连接基团来实现光学官能团。 本发明还包括使用本发明的一种或多种光学剂的成像和治疗方法，其包括具有相关治疗剂的光学功能性壳交联胶束。
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9.发明授权Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications 失效包含两亲共聚物的颗粒，具有交联的壳结构域和内部核心结构域，可用于制药和其它应用公开(公告)号：US06383500B1
公开(公告)日：2002-05-07
申请号：US08902614
申请日：1997-06-27
IPC分类号： A61K700
CPC分类号： A61K9/5138 , A61K9/1075 , C08J3/246 , Y10T428/2998
摘要： Provided are particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain. Also provided are compositions comprising such particles, including pharmaceutical compositions, methods of making the present particles, and methods of using such particles, for example for delivery of pharmaceutically active agents.
摘要翻译： 提供了包含具有交联壳结构域和内部核心结构域的两亲共聚物的颗粒。 还提供了包含这种颗粒的组合物，包括药物组合物，制备本发明颗粒的方法，以及使用这些颗粒的方法，例如用于递送药物活性剂。
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公开(公告)号：US20180016390A1
公开(公告)日：2018-01-18
申请号：US15650244
申请日：2017-07-14
申请人： Karen L. Wooley , Simcha E. Felder , Brooke A. Versaw , Ashlee A. Jahnke , Lauren A. Link , Mark W. Wooley , Charles A. Hinton , William R. Howell, JR.
发明人： Karen L. Wooley , Simcha E. Felder , Brooke A. Versaw , Ashlee A. Jahnke , Lauren A. Link , Mark W. Wooley , Charles A. Hinton , William R. Howell, JR.
CPC分类号： C08G64/0216 , C08G75/02 , C08G75/045 , C08G75/12 , C12P19/04
摘要： Degradable polycarbonates network based bulk materials are provided. The bulk materials of the present disclosure may be produced having a wide range of tunable mechanical, physical, and thermal properties and are hydrolytically degradable. The bulk materials of the present disclosure may be suitable for the manufacture of a variety of sport fishing equipment or other equipment for water use or that may benefit from hydrolytic degradation in the environment.
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