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1.发明授权Vascular cells genetically altered to over-express angiogenic proliferation and maturation factors; treatment of atherosclerosis using same 有权血管细胞遗传改变以过表达血管生成增殖和成熟因子; 用同样的方法治疗动脉粥样硬化公开(公告)号：US07767201B2
公开(公告)日：2010-08-03
申请号：US10429093
申请日：2003-05-02
Applicant: Moshe Y. Flugelman , Zoya Gluzman , Meir Preis , Belly Koren , Tzafra Cohen , Adili Tsaba , Anat Weisz
Inventor： Moshe Y. Flugelman , Zoya Gluzman , Meir Preis , Belly Koren , Tzafra Cohen , Adili Tsaba , Anat Weisz
CPC classification number: A61K49/0056 , A61K48/005 , A61K49/0047 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/52 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2840/203 , C12N2840/206
Abstract: This invention relates to a method for producing angiogenesis in a tissue of a patient by administering vascular cells genetically altered to over-express an angiogenic proliferation factor and an angiogenic maturation factor to the affected tissue.
Abstract translation: 本发明涉及一种用于在患者组织中产生血管发生的方法，该方法是通过将经遗传改变以过度表达血管生成增殖因子的血管细胞和血管生成成熟因子施用于受影响的组织。
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2.发明授权公开(公告)号：US07524493B2
公开(公告)日：2009-04-28
申请号：US10468404
申请日：2002-02-28
Applicant: Moshe Y. Flugelman , Zoya Gluzman , Meir Preis , Belly Koren , Tzafra Cohen , Adili Tsaba , Michael Ott
Inventor： Moshe Y. Flugelman , Zoya Gluzman , Meir Preis , Belly Koren , Tzafra Cohen , Adili Tsaba , Michael Ott
CPC classification number: A61K38/1866 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K48/005 , A61M25/10 , A61M2025/1052 , C07K14/47 , C12N2710/10343 , C12N2740/13043 , C12N2799/022 , C12N2799/027 , A61K2300/00
Abstract: A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged liver tissue region of the individual, at least one of the at least two distinct growth factors being an angiogenic factor.
Abstract translation: 提供了在个体损伤的肝组织区域诱导肝再生的方法。 该方法包括向个体的损伤的肝组织区域提供至少两个不同的生长因子的步骤，所述至少两个不同的生长因子中的至少一个是血管生成因子。
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3.发明授权Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b 有权使用MicroRNA-10b测定新辅助治疗和存活的反应的方法公开(公告)号：US08580513B2
公开(公告)日：2013-11-12
申请号：US13172047
申请日：2011-06-29
Applicant: Lorenzo F. Sempere , Murray Korc , Meir Preis
Inventor： Lorenzo F. Sempere , Murray Korc , Meir Preis
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6841 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207 , C12Q2563/131
Abstract: The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay.
Abstract translation: 本发明提供了基于微小RNA表达水平和任选地在诸如福尔马林固定的石蜡包埋样品中的蛋白质癌细胞标记物的存在来确定胰腺导管腺癌中新辅助治疗和无转移生存的响应的方法，所述生物样品使用 原位杂交和任选的免疫组织化学测定。
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4.发明申请Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b 有权使用MicroRNA-10b测定新辅助治疗和存活反应的方法公开(公告)号：US20120021415A1
公开(公告)日：2012-01-26
申请号：US13172047
申请日：2011-06-29
Applicant: Lorenzo F. Sempere , Murray Korc , Meir Preis
Inventor： Lorenzo F. Sempere , Murray Korc , Meir Preis
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6841 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207 , C12Q2563/131
Abstract: The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay.
Abstract translation: 本发明提供了基于微小RNA表达水平和任选地在诸如福尔马林固定的石蜡包埋样品中的蛋白质癌细胞标记物的存在来确定胰腺导管腺癌中新辅助治疗和无转移生存的响应的方法，所述生物样品使用 原位杂交和任选的免疫组织化学测定。
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