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    Pyrimidine substituted purine derivatives
    3.
    发明授权
    Pyrimidine substituted purine derivatives 有权
    嘧啶取代嘌呤衍生物

    公开(公告)号：US08247410B2

    公开(公告)日：2012-08-21

    申请号：US12681584

    申请日：2008-10-03

    Applicant: Harish K. Nagaraj ,  Meredith Williams

    Inventor： Harish K. Nagaraj ,  Meredith Williams

    IPC: A61K31/535 ,  C07D413/14

    CPC classification number: C07D473/32 ,  C07D473/40

    Abstract: The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative conditions or disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative conditions or disorders including tumors and cancers as well as other disorders or conditions related to or associated with PI3 and/or mTOR kinases.

    Abstract translation: 本发明涉及可用作激酶抑制剂的嘌呤化合物。 更具体地，本发明涉及嘌呤化合物，其制备方法，含有这些化合物的药物组合物以及这些化合物在治疗增殖性疾病或病症中的用途。 这些化合物可用作治疗许多增殖性病症或病症的药物，包括肿瘤和癌症以及与PI3和/或mTOR激酶相关或相关的其它病症或病症。

    LEGAL PROJECT MANAGEMENT SYSTEM AND METHOD
    7.
    发明申请
    LEGAL PROJECT MANAGEMENT SYSTEM AND METHOD 审中-公开
    法律项目管理制度与方法

    公开(公告)号：US20130231971A1

    公开(公告)日：2013-09-05

    申请号：US13593244

    申请日：2012-08-23

    Applicant: JUDY BISHOP ,  Mike Burks ,  John Christenson ,  Paul Davis ,  Felicia Morris ,  William Painter ,  Jennifer Reese ,  David Rueff ,  Meredith Williams ,  Conda Winchester

    Inventor： JUDY BISHOP ,  Mike Burks ,  John Christenson ,  Paul Davis ,  Felicia Morris ,  William Painter ,  Jennifer Reese ,  David Rueff ,  Meredith Williams ,  Conda Winchester

    IPC: G06Q10/06

    CPC classification number: G06Q10/063114

    Abstract: A computer-implemented system for developing, tracking and managing legal (and other professional services) projects or matters through the Legal Project Management (LPM) process. The LPM process divides the management of a legal matter or project into three phases: Project Development; Project Execution; and Project Closure. The Project Development Phase includes conflict screening, fee arrangements, identification of the nature and scope of the matter, the goals of the stakeholders, the tasks associated with the matter, and development of a schedule, budget, and a communications plan. The Project Execution Phase involves monitoring the progress of the matter, tracking the actual time and cost to budget, identifying risks and changes to the scope of the matter as they develop, and communicating among team members. The Project Closure Phase includes file closure procedures, and team and client meetings to identify lessons learned in the engagement for future improvement.

    Abstract translation: 通过法律项目管理（LPM）流程开发，跟踪和管理法律（和其他专业服务）项目或事项的计算机实施系统。 LPM过程将法律事务或项目的管理分为三个阶段：项目开发; 项目执行; 和项目关闭。 项目开发阶段包括冲突筛选，费用安排，确定事项的性质和范围，利益攸关方的目标，与事项相关的任务以及制定时间表，预算和通信计划。 项目执行阶段包括监测事项的进展情况，跟踪实际的时间和成本，预算，确定风险和发生变化的范围，以及团队成员之间的沟通。 项目关闭阶段包括文件关闭程序，以及团队和客户会议，以确定参与未来改进的经验教训。

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