公开(公告)号：US5051254A

公开(公告)日：1991-09-24

申请号：US252075

申请日：1988-09-30

Applicant: Mette Strand

Inventor： Mette Strand

IPC: A61K39/00 ,  C07K14/435 ,  C07K16/18 ,  C07K19/00

CPC classification number: C07K14/4354 ,  C07K16/18 ,  C07K19/00 ,  A61K39/00

Abstract: Polypeptide epitopes are defined herein which when used as components of vaccine compositions, induced partial immunity to Schistosoma mansoni. The epitopes are found on the surface of schistosomula. The epitopes are part of larger proteins which are immunologically cross-reactive with myosin heavy chains from other species. However, anti-myosin antibodies directed against myosin molecules of other species are not cross-reactive with the surface epitopes of S. mansoni.

Abstract translation: 多肽表位在本文中定义，当用作疫苗组合物的组分时，诱导对曼氏血吸虫的部分免疫。 血吸虫表面发现表位。 表位是与来自其他物种的肌球蛋白重链免疫交叉反应的较大蛋白质的一部分。 然而，针对其他物种的肌球蛋白分子的抗肌球蛋白抗体不与曼氏假单胞菌的表面表位交叉反应。

公开(公告)号：US4416866A

公开(公告)日：1983-11-22

申请号：US297290

申请日：1981-08-28

Applicant: Mette Strand

Inventor： Mette Strand

IPC: A61K38/00 ,  C07K16/20 ,  G01N33/00

CPC classification number: C07K16/20 ,  A61K38/00

Abstract: Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. Fluke infections are screened by determining presence of fluke antigens defined by antibodies produced by hybridomas ATCC HB-8086 and HB-8087. Chronic and acute fluke infections are distinguished by determining presence of fluke spine protein. Fluke infections are combated by injecting warm-blooded animals with antibodies produced by hybridomas ATCC HB-8086, HB-8087 and HB-8088, or with proteins defined by those antibodies.

Abstract translation: 公开了提供一种检测方法的抗体和抗原以及一种防治吸虫的方法。 通过确定由杂交瘤ATCC HB-8086和HB-8087产生的抗体定义的抗原抗原的存在来筛选Fluke感染。 通过确定侥幸脊椎蛋白的存在来区分慢性和急性感冒感染。 通过注射温血动物与由杂交瘤ATCC HB-8086，HB-8087和HB-8088产生的抗体或由那些抗体定义的蛋白质来抗击Fluke感染。

公开(公告)号：US5219566A

公开(公告)日：1993-06-15

申请号：US725804

申请日：1991-07-09

Applicant: Mette Strand

Inventor： Mette Strand

IPC: A61K39/00 ,  C07K14/435 ,  C07K16/18 ,  C07K19/00

CPC classification number: C07K19/00 ,  C07K14/4354 ,  C07K16/18 ,  A61K39/00

Abstract: Polypeptide epitopes are defined herein which when used as components of vaccine compositions, induced partial immunity to Schistosoma mansoni. The epitopes are found on the surface of schistosumula. The epitopes are part of larger proteins which are immunologically cross-reactive with myosin heavy chains from other species. However, anti-myosin antibodies directed against myosin molecules of other species are not cross-reactive with the surface epitopes of S. mansoni.

Abstract translation: 多肽表位在本文中定义，当用作疫苗组合物的组分时，诱导对曼氏血吸虫的部分免疫。 在血吸虫表面发现表位。 表位是与来自其他物种的肌球蛋白重链免疫交叉反应的较大蛋白质的一部分。 然而，针对其他物种的肌球蛋白分子的抗肌球蛋白抗体不与曼氏假单胞菌的表面表位交叉反应。

公开(公告)号：US4472509A

公开(公告)日：1984-09-18

申请号：US386110

申请日：1982-06-07

Applicant: Otto A. Gansow ,  Mette Strand

Inventor： Otto A. Gansow ,  Mette Strand

IPC: A61K51/10 ,  C07K16/10 ,  C07K16/18 ,  C07K16/30 ,  A61K39/00 ,  A61K39/42 ,  A61K43/00 ,  A61K49/00

CPC classification number: A61K51/1093 ,  C07K16/1036 ,  C07K16/18 ,  C07K16/3015 ,  A61K2121/00 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/819

Abstract: Methods of manufacturing and purifying metal chelate conjugated monoclonal antibodies are described. The chelated metal may be one which emits alpha, beta or gamma radiation, or positrons. Alternatively, the metal can be one which is fluorogenic or paramagnetic. The conjugates are suited for diagnostic and therapeutic uses.

Abstract translation: 描述了制备和纯化金属螯合物共轭单克隆抗体的方法。 螯合金属可以是发射α，β或γ辐射的金属或正电子。 或者，金属可以是荧光或顺磁性的金属。 缀合物适用于诊断和治疗用途。

公开(公告)号：US4530908A

公开(公告)日：1985-07-23

申请号：US489004

申请日：1983-04-27

Applicant: Mette Strand

Inventor： Mette Strand

IPC: A61K38/00 ,  C07K16/20 ,  G01N33/577 ,  G01N33/48 ,  C12N15/00 ,  G01N33/56

CPC classification number: G01N33/577 ,  C07K16/20 ,  A61K38/00 ,  Y10S435/948 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S530/806 ,  Y10S530/809 ,  Y10S530/828 ,  Y10S530/855

Abstract: Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded animal is provided which comprises the testing of body serum or body fluids for the presence of fluke spine glycoprotein or anti-spine antibodies. Fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088, as well as the antibodies produced by the fused cell hybrids, are also provided.

Abstract translation: 公开了提供一种检测方法的抗体和抗原以及一种防治吸虫的方法。 提供了用于测定温血动物中的活性吸虫感染的诊断方法，其包括测试身体血清或体液以存在侥幸脊柱糖蛋白或抗脊椎抗体。 还提供了融合细胞杂交瘤ATCC HB-8086，ATCC HB-8087和ATCC HB-8088，以及由融合细胞杂交体产生的抗体。

公开(公告)号：US4454106A

公开(公告)日：1984-06-12

申请号：US386109

申请日：1982-06-07

Applicant: Otto A. Gansow ,  Mette Strand

Inventor： Otto A. Gansow ,  Mette Strand

IPC: A61K51/10 ,  C07K16/10 ,  C07K16/18 ,  C07K16/30 ,  G01N33/60 ,  A61K43/00 ,  A61K49/02

CPC classification number: C07K16/18 ,  A61K51/1093 ,  C07K16/1036 ,  C07K16/3015 ,  A61K2121/00 ,  Y10S436/804 ,  Y10S436/819

Abstract: Therapeutic and diagnostic methods employing metal chelate conjugated monoclonal antibodies are described. Metals employed in therapeutic conjugated antibodies include alpha particle, beta particle or Auger electron emitting isotopes. Diagnostic methods may be either in vivo or in vitro. Chelated metals employed in diagnostic techniques may include, inter alia, gamma or positron emitting metals as well as fluorogenic or paramagnetic metals.

Abstract translation: 描述了使用金属螯合物缀合的单克隆抗体的治疗和诊断方法。 用于治疗性结合抗体的金属包括α粒子，β粒子或俄歇电子发射同位素。 诊断方法可以是体内或体外。 用于诊断技术的螯合金属尤其可以包括γ或正电子发射金属以及荧光或顺磁金属。