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公开(公告)号：US08936630B2
公开(公告)日：2015-01-20
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。
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公开(公告)号：US20110125078A1
公开(公告)日：2011-05-26
申请号：US12951852
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
摘要翻译： 用于递送光学刺激的方法包括用对波长范围内的光敏感的光敏通道蛋白转染靶组织，通过光学刺激装置将波长范围内的光传送到目标组织，基本上同时将光传递到靶 组织，感测生物电信号，基于生物电信号确定患者治疗状态，以及基于感测到的患者治疗状态来调整到目标组织的光的传送。
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公开(公告)号：US20110125077A1
公开(公告)日：2011-05-26
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。
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