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公开(公告)号：US09061161B2
公开(公告)日：2015-06-23
申请号：US13596944
申请日：2012-08-28
CPC分类号： A61N1/3754 , A61N1/3968 , H03H7/0138 , H03H2001/0042 , H05K13/00 , Y10T29/43 , Y10T29/435 , Y10T29/49002 , Y10T29/49165 , Y10T29/49171 , Y10T29/49208
摘要： In one example, a filtered feedthrough assembly for a medical device, such as, e.g., an implantable medical device, is described. The filtered feedthrough assembly may comprise a feedthrough comprising at least one feedthrough conductive pathway extending between a first feedthrough side and a second feedthrough side; a capacitive filter array comprising at least one filter array conductive pathway extending between a first filter array side and a second filter array side, and at least one capacitor filter substantially surrounding at least a portion the at least one filter array conductive pathway; and at least one electrically conductive member electrically coupling the at least one filter array conductive pathway to the at least one feedthrough conductive pathway.
摘要翻译： 在一个示例中，描述了用于医疗装置的过滤馈通组件，例如可植入医疗装置。 滤波的馈通组件可以包括馈通，其包括在第一馈通侧和第二馈通侧之间延伸的至少一个馈通导电路径; 电容滤波器阵列，包括在第一滤波器阵列侧和第二滤波器阵列侧之间延伸的至少一个滤波器阵列导电路径，以及基本上围绕所述至少一个滤波器阵列导电路径的至少一部分的至少一个电容滤波器; 以及至少一个导电构件，其将所述至少一个过滤器阵列导电路径电耦合到所述至少一个馈通导电路径。
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公开(公告)号：US08936630B2
公开(公告)日：2015-01-20
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。
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公开(公告)号：US08509899B2
公开(公告)日：2013-08-13
申请号：US13008524
申请日：2011-01-18
申请人： John Louis Sommer , Joseph Michael D'Sa , Joyce K. Yamamoto , Brad C. Tischendorf , James D. Reinke , Andrew J. Thom , Thomas P. Miltich , William John Taylor , Kenneth C. Gardeski , Larry Earl Tyler , Jeffrey O. York , Gordon O. Munns
发明人： John Louis Sommer , Joseph Michael D'Sa , Joyce K. Yamamoto , Brad C. Tischendorf , James D. Reinke , Andrew J. Thom , Thomas P. Miltich , William John Taylor , Kenneth C. Gardeski , Larry Earl Tyler , Jeffrey O. York , Gordon O. Munns
IPC分类号： A61N1/362
摘要： Hermetically sealed assemblies, for example, that include IC chips, are configured for incorporation within a connector terminal of an implantable medical electrical lead, preferably within a contact member of the terminal. An assembly may include two feedthrough subassemblies, welded to either end of the contact member, to form an hermetic capsule, in which an IC chip is enclosed, and a tubular member, which allows a lumen to extend therethrough, along a length of the terminal. A multi-electrode lead may include multiplexer circuitry, preferably a switch matrix element and a communications, control and power supply element that are electrically coupled to the contact member and to another contact member of the terminal. Each pair of switch matrix switches allows for any two of the electrodes to be selected, in order to deliver a stimulation vector, via stimulation pulses from a device/pulse generator, to which the connector terminal is connected.
摘要翻译： 例如，包括IC芯片的密封组件被配置为并入可植入医疗电线的连接器端子内，优选地在端子的接触构件内。 组件可以包括焊接到接触构件的任一端的两个馈通子组件，以形成封闭IC芯片的密封胶囊，以及允许内腔沿着端子的长度延伸穿过的管状构件 。 多电极引线可以包括多路复用器电路，优选地是开关矩阵元件和通信，控制和电源元件，其电耦合到接触构件和终端的另一接触构件。 每对开关矩阵开关允许选择任何两个电极，以便通过来自连接器端子连接到的装置/脉冲发生器的刺激脉冲传送刺激矢量。
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公开(公告)号：US20130127567A1
公开(公告)日：2013-05-23
申请号：US13596944
申请日：2012-08-28
CPC分类号： A61N1/3754 , A61N1/3968 , H03H7/0138 , H03H2001/0042 , H05K13/00 , Y10T29/43 , Y10T29/435 , Y10T29/49002 , Y10T29/49165 , Y10T29/49171 , Y10T29/49208
摘要： In one example, a filtered feedthrough assembly for a medical device, such as, e.g., an implantable medical device, is described. The filtered feedthrough assembly may comprise a feedthrough comprising at least one feedthrough conductive pathway extending between a first feedthrough side and a second feedthrough side; a capacitive filter array comprising at least one filter array conductive pathway extending between a first filter array side and a second filter array side, and at least one capacitor filter substantially surrounding at least a portion the at least one filter array conductive pathway; and at least one electrically conductive member electrically coupling the at least one filter array conductive pathway to the at least one feedthrough conductive pathway.
摘要翻译： 在一个示例中，描述了用于医疗装置的过滤馈通组件，例如可植入医疗装置。 滤波的馈通组件可以包括馈通，其包括在第一馈通侧和第二馈通侧之间延伸的至少一个馈通导电路径; 电容滤波器阵列，包括在第一滤波器阵列侧和第二滤波器阵列侧之间延伸的至少一个滤波器阵列导电路径，以及基本上围绕所述至少一个滤波器阵列导电路径的至少一部分的至少一个电容滤波器; 以及至少一个导电构件，其将所述至少一个过滤器阵列导电路径电耦合到所述至少一个馈通导电路径。
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公开(公告)号：US20120165902A1
公开(公告)日：2012-06-28
申请号：US13008524
申请日：2011-01-18
申请人： John Louis Sommer , Joseph Michael D'Sa , Joyce K. Yamamoto , Brad C. Tischendorf , James D. Reinke , Andrew J. Thom , Thomas P. Miltich , William John Taylor , Kenneth C. Gardeski , Larry Earl Tyler , Jeffrey O. York , Gordon O. Munns
发明人： John Louis Sommer , Joseph Michael D'Sa , Joyce K. Yamamoto , Brad C. Tischendorf , James D. Reinke , Andrew J. Thom , Thomas P. Miltich , William John Taylor , Kenneth C. Gardeski , Larry Earl Tyler , Jeffrey O. York , Gordon O. Munns
IPC分类号： A61N1/36
摘要： Hermetically sealed assemblies, for example, that include IC chips, are configured for incorporation within a connector terminal of an implantable medical electrical lead, preferably within a contact member of the terminal. An assembly may include two feedthrough subassemblies, welded to either end of the contact member, to form an hermetic capsule, in which an IC chip is enclosed, and a tubular member, which allows a lumen to extend therethrough, along a length of the terminal. A multi-electrode lead may include multiplexer circuitry, preferably a switch matrix element and a communications, control and power supply element that are electrically coupled to the contact member and to another contact member of the terminal. Each pair of switch matrix switches allows for any two of the electrodes to be selected, in order to deliver a stimulation vector, via stimulation pulses from a device/pulse generator, to which the connector terminal is connected.
摘要翻译： 例如，包括IC芯片的密封组件被配置为并入可植入医疗电线的连接器端子内，优选地在端子的接触构件内。 组件可以包括焊接到接触构件的任一端的两个馈通子组件，以形成封闭IC芯片的密封胶囊，以及允许内腔沿着端子的长度延伸穿过的管状构件 。 多电极引线可以包括多路复用器电路，优选地是开关矩阵元件和通信，控制和电源元件，其电耦合到接触构件和终端的另一接触构件。 每对开关矩阵开关允许选择任何两个电极，以便通过连接器端子连接到的装置/脉冲发生器的刺激脉冲传送刺激矢量。
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公开(公告)号：US20110125078A1
公开(公告)日：2011-05-26
申请号：US12951852
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
摘要翻译： 用于递送光学刺激的方法包括用对波长范围内的光敏感的光敏通道蛋白转染靶组织，通过光学刺激装置将波长范围内的光传送到目标组织，基本上同时将光传递到靶 组织，感测生物电信号，基于生物电信号确定患者治疗状态，以及基于感测到的患者治疗状态来调整到目标组织的光的传送。
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公开(公告)号：US20110125077A1
公开(公告)日：2011-05-26
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译： 提供了从光学刺激装置向目标组织递送光学刺激的方法。 一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。 另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。 另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由 光学光导。
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