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1.发明授权Multiparticle pharmaceutical dosage form for a low-soluble active substances and method for producing said pharmaceutical dosage form 有权用于低溶性活性物质的多颗粒药物剂型和用于生产所述药物剂型的方法公开(公告)号：US08273375B2
公开(公告)日：2012-09-25
申请号：US11572720
申请日：2005-07-08
IPC分类号： A61K9/14 , A61K31/513 , A61K31/4439 , A61K31/55
CPC分类号： A61K31/506 , A61K9/1617 , A61K9/1652 , A61K9/5026 , A61K9/5078 , A61K31/427 , A61K31/55
摘要： The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 μn substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect. A method for producing the inventive multiparticle pharmaceutical dosage is also disclosed.
摘要翻译： 本发明涉及一种口腔形式的口服多颗粒药物剂型，其为减少胃的pH值的容器，其含有多个颗粒，颗粒，颗粒或附聚物，其平均直径范围为50至2500μn，可替代地由a）内部 含有不是肽或蛋白质的活性剂的基质层，也不是其衍生物或共轭物，其熔点大于37℃的亲脂基质和具有粘膜粘附作用的聚合物，b）由 聚合物或阴离子共聚物，其任选地与常规药物添加剂配制，其中活性剂具有根据DAB 10的水溶性，至少30体积份的水用于1重量份的活性剂，并且用亲脂性 基质和所述含活性剂的亲脂基质涂覆有由具有粘膜粘附作用的聚合物制成的基质。 还公开了用于生产本发明的多颗粒药物剂量的方法。
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公开(公告)号：US20110015266A1
公开(公告)日：2011-01-20
申请号：US12922787
申请日：2009-02-26
IPC分类号： A61K47/26 , A61K31/216
CPC分类号： A61K9/1075 , A61K9/19 , A61K47/14 , A61K47/26 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S977/906 , Y10S977/907
摘要： The present invention relates to a lyophilised nanoemulsion comprising a lipophilic phase and one or more sucrose fatty acid esters, to the nanoemulsion which can be prepared from the lyophilised nanoemulsion by redispersion, and to a process for the preparation of the lyophilised nanoemulsion.
摘要翻译： 本发明涉及包含亲油相和一种或多种蔗糖脂肪酸酯的冻干纳米乳液，其可通过再分散从所述冻干的纳米乳液制备的纳米乳液，以及制备所述冻干的纳米乳液的方法。
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公开(公告)号：US08697131B2
公开(公告)日：2014-04-15
申请号：US13138389
申请日：2010-02-11
CPC分类号： A61K9/14 , A61K9/1635 , A61K9/1652
摘要： Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
摘要翻译： 通过将溶剂 - 非溶剂沉淀物与原位喷雾干燥方法组合来制备小粒径的药物药物颗粒。 将药物分散在水混溶性溶剂，特别是乙醇中，并在进料管线中在压力下加热到高于溶剂沸点直到药物溶解。 这种溶液在气体渗透的微反应器中作为细水射流与细水射流碰撞，并且所产生的细雾迅速蒸发。 有机溶剂首先蒸发，然后蒸发。 水可能含有表面改性剂。
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4.发明授权Quarternization of the additive amino alkylmethacrylate copolymer E for improving permeability and solubility of pharmaceuticals 有权氨基甲基丙烯酸烷基酯共聚物E的改性，用于提高药物的渗透性和溶解度公开(公告)号：US08399523B2
公开(公告)日：2013-03-19
申请号：US12747722
申请日：2008-12-12
申请人： Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
发明人： Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
CPC分类号： A61K47/32 , C08F26/02 , C08F220/10 , C08F220/34
摘要： The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quaternization of a fraction of the existing amino alkyl groups.
摘要翻译： 本发明涉及基于加入化学修饰的氨基甲基丙烯酸烷基酯共聚物E来提高药物的渗透性和溶解度的策略，其中化学修饰是一部分现有氨基烷基的季铵化。
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5.发明申请DEVICE FOR INFLUENCING THE MOVEMENT OF FURNITURE PARTS WHICH CAN BE MOVED WITH RESPECT TO ONE ANOTHER, AND PIECE OF FURNITURE 有权用于影响可以移动的家具部件的运动的装置，另一方面，以及家具公开(公告)号：US20090096337A1
公开(公告)日：2009-04-16
申请号：US12233876
申请日：2008-09-19
IPC分类号： A47B88/04
CPC分类号： A47B88/463 , A47B88/457 , A47B2210/0078
摘要： The invention relates to a piece of furniture and to a device for influencing the movement of furniture parts which can be moved with respect to one another, having a guide unit for guidance of a first furniture part on a second furniture part, and having a drive unit by means of which the first furniture part can be moved, in a driven manner, relative to the second furniture part, with the guide unit having a fixed rail, which is associated with the second furniture part, and a moving rail, which is associated with the first furniture part. A pulling-pushing element is provided in order to apply a drive effect from the drive unit to the first furniture part, guided on the fixed rail via guide means.
摘要翻译： 本发明涉及一种家具和用于影响可相对于彼此移动的家俱部件的运动的装置，具有用于引导第二家具部件上的第一家具部件的引导单元，并具有驱动器 第一家具部件可以相对于第二家具部件以驱动的方式移动，导向单元具有与第二家具部件相关联的固定轨道，移动轨道是 与第一家具部件相关联。 提供推拉元件，以便通过引导装置将来自驱动单元的驱动效应施加到在固定轨道上引导的第一家具部件。
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6.发明申请Particulate System For Use in Diminishing Cell Growth/Inducing Cell Killing 审中-公开用于减少细胞生长/诱导细胞杀伤的颗粒系统公开(公告)号：US20140350323A1
公开(公告)日：2014-11-27
申请号：US14344544
申请日：2012-09-12
申请人： Peter Langguth , Karl Buch , Thomas Nawroth , Heinz Schmidberger
发明人： Peter Langguth , Karl Buch , Thomas Nawroth , Heinz Schmidberger
CPC分类号： A61K9/1647 , A61K9/5153 , A61K33/24 , A61K41/0038 , A61K51/1241 , A61N5/10 , A61N2005/1098
摘要： The Invention relates to a particulate system for use in diminishing cell growth, in particular the growth of cancer cells, comprising one or more water soluble lanthanide compounds that are embedded in a solid biodegradable polymer particle, the polymer being selected from the group consisting of polycarbonic acids, polylactic acids, polyglycolic acids, polypeptides or combinations thereof.
摘要翻译： 本发明涉及用于减少细胞生长，特别是癌细胞生长的颗粒系统，其包含一种或多种嵌入固体可生物降解的聚合物颗粒中的水溶性镧系元素化合物，所述聚合物选自聚碳酸酯 酸，聚乳酸，聚乙醇酸，多肽或其组合。
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公开(公告)号：US08211948B2
公开(公告)日：2012-07-03
申请号：US12922787
申请日：2009-02-26
CPC分类号： A61K9/1075 , A61K9/19 , A61K47/14 , A61K47/26 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S977/906 , Y10S977/907
摘要： The present invention relates to a lyophilized nanoemulsion comprising a lipophilic phase and one or more sucrose fatty acid esters, to the nanoemulsion which can be prepared from the lyophilized nanoemulsion by redispersion, and to a process for the preparation of the lyophilized nanoemulsion.
摘要翻译： 本发明涉及包含亲脂相和一种或多种蔗糖脂肪酸酯的冻干纳米乳剂，其可通过再分散由冻干的纳米乳液制备的纳米乳剂，以及制备冻干的纳米乳液的方法。
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8.发明申请公开(公告)号：US20110294770A1
公开(公告)日：2011-12-01
申请号：US13138389
申请日：2010-02-11
IPC分类号： A61K31/58 , A61P3/10 , A61P5/24 , A61K31/403
CPC分类号： A61K9/14 , A61K9/1635 , A61K9/1652
摘要： Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
摘要翻译： 通过将溶剂 - 非溶剂沉淀物与原位喷雾干燥方法组合来制备小粒径的药物药物颗粒。 将药物分散在水混溶性溶剂，特别是乙醇中，并在进料管线中在压力下加热到高于溶剂沸点直到药物溶解。 这种溶液在气体渗透的微反应器中作为细水射流与细水射流碰撞，并且所产生的细雾迅速蒸发。 有机溶剂首先蒸发，然后蒸发。 水可能含有表面改性剂。
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9.发明申请QUARTERNIZATION OF THE ADDITIVE AMINO ALKYLMETHACRYLATE COPOLYMER E FOR IMPROVING PERMEABILITY AND SOLUBILITY OF PHARMACEUTICALS 有权用于改善药物渗透性和溶解性的添加剂氨基甲基丙烯酸甲酯共聚物E的分级公开(公告)号：US20100286288A1
公开(公告)日：2010-11-11
申请号：US12747722
申请日：2008-12-12
申请人： Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
发明人： Peter Langguth , Stefan Grube , Holger Frey , Boris Obermeier
CPC分类号： A61K47/32 , C08F26/02 , C08F220/10 , C08F220/34
摘要： The present invention relates to a strategy for improving the permeability and solubility of pharmaceuticals, based on adding a chemically modified amino alkyl methacrylate copolymer E, wherein the chemical modification is the quaternization of a fraction of the existing amino alkyl groups.
摘要翻译： 本发明涉及基于加入化学修饰的氨基甲基丙烯酸烷基酯共聚物E来提高药物的渗透性和溶解度的策略，其中化学修饰是一部分现有氨基烷基的季铵化。
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公开(公告)号：US5591012A
公开(公告)日：1997-01-07
申请号：US271523
申请日：1994-07-07
申请人： Peter Langguth , Ewald Kille
发明人： Peter Langguth , Ewald Kille
CPC分类号： F04B9/047 , F04B23/023
摘要： In a conveying pump having a cylinder introducible into a reservoir and having a pump piston, whereby the conveyed medium is supplied via an ascending line to a discharge line, an ascending line formed of two sections adjustable relative to one another is provided. The ascending line can be locked at different heights to vary the length of the ascending line so that the conveying pump can be used for reservoirs of different heights without deteriorating the conveying capacity of the pump. This adaptation can be performed easily and quickly. In addition, the conveying pump can be taken apart and easily cleaned, and component parts can be easily replaced.
摘要翻译： 在具有引入容器并具有泵活塞的气缸的输送泵中，由此将输送的介质经由上升管道供给到排放管线，提供由相对于彼此可调节的两个部分形成的上升线。 升降线可以在不同的高度被锁定以改变上升线的长度，使得输送泵可以用于不同高度的储存器，而不会降低泵的输送能力。 这种适应可以方便快捷地进行。 此外，输送泵可以分离并容易地清洁，并且可以容易地更换部件。
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