公开(公告)号：US20070259354A1

公开(公告)日：2007-11-08

申请号：US11536394

申请日：2006-09-28

申请人： Guy Servant ,  Paul Brust ,  Bryan Moyer ,  Min Lu ,  Fernando Echeverri ,  David Dahan ,  Mark Zoller ,  Mark Williams ,  Rachel Kimmich ,  Poonit Kamdar ,  Tanya Ditschun ,  Andrew Patron

发明人： Guy Servant ,  Paul Brust ,  Bryan Moyer ,  Min Lu ,  Fernando Echeverri ,  David Dahan ,  Mark Zoller ,  Mark Williams ,  Rachel Kimmich ,  Poonit Kamdar ,  Tanya Ditschun ,  Andrew Patron

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N5/10

CPC分类号： C07K14/705

摘要： Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.

摘要翻译： 提供了在人细胞中有效表达的修饰的人TRPM8核酸序列和基于细胞的测定和含有其的测试试剂盒。 这些测定使用表达根据本发明的修饰的人TRPM8核酸序列的细胞鉴定TRPM8调节剂，其中所述序列相对于野生型人类TRPM8核酸序列已被修饰，以优化所需细胞中的离子通道表达。 已经显示使用这些修饰的TRPM8序列的测定来鉴定与已知的冷却剂如薄荷醇和icilin更好或相当地调节人类TRPM8离子通道的化合物。

公开(公告)号：US20070003680A1

公开(公告)日：2007-01-04

申请号：US11455314

申请日：2006-06-15

申请人： Catherine Tachdjian ,  Andrew Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

发明人： Catherine Tachdjian ,  Andrew Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

IPC分类号： A23L1/236

CPC分类号： A23L2/39 ,  A23G3/36 ,  A23G9/32 ,  A23L7/122 ,  A23L27/204 ,  A23L27/205 ,  A23L27/30 ,  A23V2002/00 ,  C07C233/11 ,  C07C233/22 ,  C07C235/34 ,  C07C235/78 ,  C07C237/20 ,  C07C255/57 ,  C07C271/22 ,  C07D213/30 ,  C07D213/85 ,  C07D239/26 ,  C07D241/24 ,  C07D307/52 ,  C07D307/54 ,  C07D333/24 ,  A23V2200/16

摘要： The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

摘要翻译： 本文公开的本发明涉及人造双芳族酰胺化合物，当与可食食品或饮料或药物组合物以优选约100ppm或更低的量级的浓度接触时，可用作甜味调味剂，甜味调味剂或 用于食品，饮料和其他可食用产品的甜味增味剂或任选在常规调味剂如已知天然糖甜味剂和先前已知的人造甜味剂存在下或与之混合的口服药物或组合物。