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公开(公告)号:US4962209A
公开(公告)日:1990-10-09
申请号:US20960
申请日:1987-03-02
申请人: Ralph W. Turner
发明人: Ralph W. Turner
IPC分类号: C07D205/08 , C07D309/30
CPC分类号: C07D309/30 , C07D205/08
摘要: This invention relates to compounds of the formula I ##STR1## wherein: R1 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted) aryl, arylalkyl or silyl (bearing alkyl, aryl or arylalkyl substituents);R2 is hydrogen or alkyl;R3 is hydrogen, alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), alkenyl, aryl, arylalkyl, amino, mono--or di--alkylamino or a group of the formula --OR5 wherein R5 is optionally substituted alkyl, aryl or arylalkyl;R4 is alkyl optionally substituted by one or more alkoxy groups or halogen atoms;Y is optionally substituted alkoxy or cycloalkoxy, arylalkoxy or a group of formula --NR6R7 wherein R6 is hydrogen or alkyl and R7 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), aryl or arylalkyl or R7 is a group of formula --COOR8 is alkyl or arylalkyl, which are useful as intermediates in the synthesis of beta-lactam antibiotics, particularly carbapenems, and to a process for the manufacture of the said compounds.
摘要翻译: 本发明涉及式Ⅰ化合物,其中:R1是烷基,环烷基(其中烷基和环烷基可被取代)芳基,芳基烷基或甲硅烷基(带有烷基,芳基或芳烷基取代基); R2是氢或烷基; R3是氢,烷基,环烷基(其中烷基和环烷基可以被取代),烯基,芳基,芳基烷基,氨基,单 - 或二 - 烷基氨基或式-OR5的基团,其中R5是任选取代的烷基,芳基或芳烷基 ; R4是任选被一个或多个烷氧基或卤素原子取代的烷基; Y是任选取代的烷氧基或环烷氧基,芳基烷氧基或式-NR6R7基团,其中R6是氢或烷基,R7是烷基,环烷基(其中烷基和环烷基可被取代),芳基或芳烷基或R7是式 - COOR8是烷基或芳基烷基,其可用作β-内酰胺抗生素,特别是碳青霉烯类合成中的中间体,以及制备所述化合物的方法。
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公开(公告)号:US5155236A
公开(公告)日:1992-10-13
申请号:US334749
申请日:1989-04-06
IPC分类号: C07D205/08 , C07D309/30 , C07D477/04
CPC分类号: C07D477/04 , C07D205/08 , C07D309/30
摘要: Compounds of formula I: ##STR1## wherein: R1 is hydrogen or alkyl;R2 is alkyl optionally substituted by one or more alkoxy groups or halogen atoms;X is a group of formula --OR3 wherein R3 is alkyl, cycloalkyl, or arylalkyl; or X is a group of formula --NHCVR4 wherein V is oxygen or sulphur, R4 is hydrogen, alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), alkenyl, aryl, arylalkyl, amino, mono- or di-alkylamino or a group of the formula --OR5 wherein R5 is optionally substituted alkyl, aryl or arylalkyl; or X is a group of formula --NHSO.sub.2 R4a wherein R4a is alkyl, aryl or a group of formula --CH.sub.2 COR4b wherein R4b is alkyl or aryl;Y is optionally substituted alkoxy, cycloalkoxy, arylalkoxy or a group of formula --NR6R7 wherein R6 is hydrogen or alkyl and R7 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), aryl or arylalkyl or R7 is a group of formula --COOR8 wherein R8 is alkyl are useful intermediates in the synthesis of beta-lactam antibiotics.
摘要翻译: 式I化合物:其中:R 1是氢或烷基; R2是任选被一个或多个烷氧基或卤素原子取代的烷基; X是式-OR3的基团,其中R3是烷基,环烷基或芳基烷基; 或X是式-NHCVR4的基团,其中V是氧或硫,R4是氢,烷基,环烷基(其烷基和环烷基可以被取代),烯基,芳基,芳基烷基,氨基,单或二 - 烷基氨基或 基团,其中R 5为任选取代的烷基,芳基或芳基烷基; 或X是式-NHSO 2 R 4 a的基团,其中R 4a是烷基,芳基或式-CH 2 COR 4 b基团,其中R 4b是烷基或芳基; Y是任选取代的烷氧基,环烷氧基,芳基烷氧基或式-NR6R7基团,其中R6是氢或烷基,R7是烷基,环烷基(其中烷基和环烷基可以被取代),芳基或芳烷基或R7是式 - 其中R8是烷基的COOR8是合成β-内酰胺抗生素的有用的中间体。
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公开(公告)号:US4327893A
公开(公告)日:1982-05-04
申请号:US154476
申请日:1980-05-29
申请人: Lothar Bachmann , John A. Powell , Ralph W. Turner
发明人: Lothar Bachmann , John A. Powell , Ralph W. Turner
摘要: A guillotine damper for a duct is provided with a thrust frame upstream of the path of a blade that is movable into and out of an operative position in sealing engagement with a seat downstream of the blade path when the flow path is not obstructed by the blade and in sealing engagement with and seating the blade against the seat when the blade is positioned to block the duct. Devices are provided with each utilizing resilient components to thrust the frame into its sealing positions and a hydraulic component to retract the frame when the blade is to be moved into or out of its duct blocking position. Each device exerts the force of either component to the frame through a series of mechanical elements spaced a substantial distance apart along the sides of the frames and connected thereto.
摘要翻译: 用于管道的闸板式阻尼器在叶片的路径的上游设置有推力框架,该推力框架可移动地进入和离开操作位置,当叶片路径未被叶片阻塞时与叶片路径下游的座密封接合 并且当刀片被定位成阻塞管道时,将刀片密封接合并将刀片固定在座椅上。 设备设有各自的利用弹性部件以将框架推入其密封位置,以及液压部件,以在叶片移入或移出其管道阻塞位置时缩回框架。 每个装置通过沿着框架的侧面间隔相当距离并连接到框架的一系列机械元件将任一部件的力施加到框架。
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公开(公告)号:US5296613A
公开(公告)日:1994-03-22
申请号:US917376
申请日:1992-07-23
IPC分类号: C07D205/08 , C07D309/30 , C07D477/04
CPC分类号: C07D477/04 , C07D205/08 , C07D309/30
摘要: Compounds of formula I: ##STR1## wherein: R1 is hydrogen or alkyl;R2 is alkyl optionally substituted by one or more alkoxy groups or halogen atoms;X is a group of formula --OR3 wherein R3 is alkyl, cycloalkyl, or arylalkyl; or X is a group of formula --NHCVR4 wherein V is oxygen or sulphur, R4 is hydrogen, alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), alkenyl, aryl, arylalkyl, amino, mono- or di-alkylamino or a group of the formula --OR5 wherein R5 is optionally substituted alkyl, aryl or arylalkyl; or X is a group of formula --NHSO.sub.2 R4a wherein R4a is alkyl, aryl or a group of formula --CH.sub.2 COR4b wherein R4b is alkyl or aryl;Y is optionally substituted alkoxy, cycloalkoxy, arylalkoxy or a group of formula --NR6R7 wherein R6 is hydrogen or alkyl and R7 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), aryl or arylalkyl or R7 is a group of formula --COOR8 wherein R8 is alkyl are useful intermediates in the synthesis of beta-lactam antibiotics.
摘要翻译: 式I化合物:其中:R 1是氢或烷基; R2是任选被一个或多个烷氧基或卤素原子取代的烷基; X是式-OR3的基团,其中R3是烷基,环烷基或芳基烷基; 或X是式-NHCVR4的基团,其中V是氧或硫,R4是氢,烷基,环烷基(其烷基和环烷基可以被取代),烯基,芳基,芳基烷基,氨基,单或二 - 烷基氨基或 基团,其中R 5为任选取代的烷基,芳基或芳基烷基; 或X是式-NHSO 2 R 4 a的基团,其中R 4a是烷基,芳基或式-CH 2 COR 4 b基团,其中R 4b是烷基或芳基; Y是任选取代的烷氧基,环烷氧基,芳基烷氧基或式-NR6R7基团,其中R6是氢或烷基,R7是烷基,环烷基(其中烷基和环烷基可以被取代),芳基或芳烷基或R7是式 - 其中R8是烷基的COOR8是合成β-内酰胺抗生素的有用的中间体。
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公开(公告)号:US4736057A
公开(公告)日:1988-04-05
申请号:US670017
申请日:1984-11-09
IPC分类号: C07D317/72 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/22 , A61K31/335 , A61K31/357 , A61P7/02 , A61P9/10 , A61P9/12 , A61P11/00 , A61P43/00 , C07C33/34 , C07C45/30 , C07C45/40 , C07C45/41 , C07C47/235 , C07C51/00 , C07C57/46 , C07C57/48 , C07C57/62 , C07C59/42 , C07C59/46 , C07C59/54 , C07C59/72 , C07C59/76 , C07C59/86 , C07C59/90 , C07C67/00 , C07C69/035 , C07C69/612 , C07C69/65 , C07C69/73 , C07C69/76 , C07C201/00 , C07C205/56 , C07C231/00 , C07C231/12 , C07C233/54 , C07C301/00 , C07C303/40 , C07C311/02 , C07C311/51 , C07C317/14 , C07D319/08
CPC分类号: C07D319/08 , C07C317/00 , C07C321/00 , C07C33/34 , C07C403/20 , C07C45/305 , C07C45/40 , C07C45/41 , C07C47/235 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/72 , C07C59/86 , C07C59/90 , C07C2101/14
摘要: This invention concerns novel (4-substituted-2-phenylcyclohexyl)alkenoic and alkanoic acid derivatives of the formula I wherein one of Ra and Rb is hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)alkenyloxy or phenyl(1-4C)alkoxy and the other of Ra and Rb is hydrogen, (1-6C)alkyl, (1-6C)alkoxy or (3-6C)alkenyloxy; or Ra and Rb together form a (2-4C)alkylenedioxy or oxo group; benzene ring X optionally bears a substituent selected from halogeno, (1-6C)alkyl, (1-6C)alkoxy, hydroxy, (2-6C)alkanoyloxy, (1-6C)alkanoylamino, trifluoromethyl and nitro; n is 3-5; Y is ethylene or vinylene; and in the cyclohexane ring, the substituents at positions 1 and 2 have cis- or trans-relative stereochemistry; and the pharmaceutically acceptable salts, (1-6C)alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I possess valuable pharmacological properties of use in medicines. The invention also concerns processes for the manufacture of, and pharmaceutical compositions containing a novel compound of formula I.
摘要翻译: 本发明涉及式I的新型(4-取代-2-苯基环己基)链烯酸衍生物,其中Ra和Rb之一是氢,羟基,(1-6C)烷基,(1-6C)烷氧基,(3- 6C)烯氧基或苯基(1-4C)烷氧基,另一个R a和R b是氢,(1-6C)烷基,(1-6C)烷氧基或(3-6C)烯氧基; 或R a和R b一起形成(2-4C)亚烷基二氧基或氧代基团; 苯环X任选带有选自卤代,(1-6C)烷基,(1-6C)烷氧基,羟基,(2-6C)烷酰氧基,(1-6C)烷酰基氨基,三氟甲基和硝基的取代基; n为3-5; Y为乙烯或亚乙烯基; 在环己烷环中,位置1和2的取代基具有顺式或反式相对立体化学; 和其药学上可接受的盐,(1-6C)烷基酯和(1-6C)烷基磺酰胺。 式I化合物具有药用中有价值的药理学性质。 本发明还涉及制备含有新型式I化合物的药物组合物和方法。
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公开(公告)号:US4673496A
公开(公告)日:1987-06-16
申请号:US774139
申请日:1985-09-09
申请人: Ralph W. Turner, Jr.
发明人: Ralph W. Turner, Jr.
CPC分类号: B01D33/073 , B01D33/44
摘要: Pulp sheet take-off apparatus which allows removal of drum valve parts from existing high vacuum rotary drum filters and significantly increases the production capability of existing and newly designed high vacuum rotary drum filters includes an enclosed take-off chamber that is mounted immediately adjacent and parallel to the face of the filter drum on the descending side thereof, the chamber being connected by piping to the filter drum barometric leg or other subatmospheric pressure source as a means of maintaining subatmospheric pressure in the chamber equal to or less than the internal pressure of the filter drum. A fixed pulp sheet slide is arranged to remove the pulp sheet from the filter surface while atmospheric air is prevented from entering into the chamber, and pulp sheet discharge mechanism includes a vaned discharge roll that is mounted immediately adjacent and parallel to the top surface of the stock slide structure and includes means for biasing the discharge roll against the pulp sheet and means for rotating the discharge roll in the direction of pulp sheet movement to draw the pulp sheet out of the take-off chamber between the roll and the stock slide structure. The pulp sheet may be discharged to atmosphere or directly to an air tight repulping or shredding vat following the filter drum, the repulping and shredding vats being directly connected to and maintaining the same subatmospheric pressure as the take-off chamber.
摘要翻译: 纸浆送纸装置允许从现有的高真空旋转鼓式过滤器中去除鼓阀部件并显着提高现有和新设计的高真空旋转鼓式过滤器的生产能力,包括一个紧密相邻并平行安装的封闭式起飞室 在其下降侧的过滤鼓的表面上,该室通过管道连接到过滤鼓气压或其它低于大气压的压力源,作为将室内的低于大气压的压力等于或小于 过滤鼓。 固定的纸浆片滑动件布置成从过滤器表面移除纸浆片,同时防止大气进入到室中,纸浆排出机构包括直接安装在平行于 储存滑块结构,并且包括用于将排出辊偏压在纸浆片上的装置,以及用于沿纸浆片移动方向旋转排出辊的装置,以将纸浆片从辊和储存滑块结构之间的取出室中拉出。 纸浆片材可以排放到大气中或直接排放到过滤鼓之后的气密重新榨制或切碎的大桶中,重新排放和切碎的桶直接连接并保持与起飞室相同的低于大气压的压力。
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