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公开(公告)号：US20240299437A1
公开(公告)日：2024-09-12
申请号：US18261882
申请日：2022-02-25
发明人： HAN OH PARK , SANG KYU LEE , OH SEUNG KWON , EUN AH GOH
IPC分类号： A61K31/7105 , A61K8/60 , A61K9/51 , A61K31/713 , A61K47/54 , A61K47/58 , A61K47/60 , A61K47/69 , A61P17/00 , A61Q5/00 , A61Q7/00 , C12N15/113
CPC分类号： A61K31/7105 , A61K8/606 , A61K9/51 , A61K31/713 , A61K47/543 , A61K47/554 , A61K47/58 , A61K47/60 , A61K47/6929 , A61P17/00 , A61Q5/00 , A61Q7/00 , C12N15/113
摘要： The present invention relates to a composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded miRNA as an active ingredient and, more specifically, to: miR-3139, miR-3189, miR-3199 or miR-8485, which are double-stranded miRNA; a double-stranded oligonucleotide structure comprising same; or a pharmaceutical or cosmetic composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising nanoparticles containing the structure as an active ingredient. A composition according to the present invention can prevent hair graying and reduce the rate of progress thereof by activating melanocytes and promoting melanogenesis and can allow the hair already affected by graying to be improved to a state before graying. In addition, the composition promotes the activation of melanocytes and the proliferation of dermal papilla cells and keratinocytes that are present in hair follicles, and induces outer root sheath development and hair growth so that the effects of promoting hair growth and/or preventing hair loss can be exhibited.
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公开(公告)号：US20230348912A1
公开(公告)日：2023-11-02
申请号：US17998662
申请日：2021-05-13
发明人： Jun Hong PARK , Han-Oh PARK , Sung Il YUN , Tae Rim KIM , Soo Hyun HWANG , Kang SONG , Sang Hyuk JUNG , Jangseon KIM , Mi Sun LEE , Soonja CHOI , Seung Seob SON
IPC分类号： C12N15/113 , A61K48/00 , A61K47/60 , A61K47/69 , A61P3/04
CPC分类号： C12N15/1136 , A61K48/0025 , A61K47/60 , A61K47/6929 , A61P3/04
摘要： The present invention relates to a double-stranded oligonucleotide capable of inhibiting amphiregulin expression in a very specific and highly efficient manner, preferably a double-stranded oligonucleotide comprising a sequence in the form of an RNA/RNA, DNA/DNA or DNA/RNA hybrid, and the use of a double-stranded oligonucleotide structure, which comprises the double-stranded oligonucleotide, and nanoparticles, for preventing or treating obesity.
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公开(公告)号：US20230203491A1
公开(公告)日：2023-06-29
申请号：US17999399
申请日：2021-05-21
发明人： Han-Oh PARK , Jangseon KIM , Mi Sun LEE , Soonja CHOI , Eun-Kwang LEE , Sang Jin BYUN
IPC分类号： C12N15/113 , A61K9/51 , A61P31/14 , A61P11/00 , A61K31/713
CPC分类号： C12N15/1131 , A61K9/51 , A61P31/14 , A61P11/00 , A61K31/713 , C12N2310/3235 , C12N2310/3231 , C12N2310/315 , C12N2310/312 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to: a double-stranded oligonucleotide which can highly specifically and efficiently inhibit the proliferation of Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), preferably a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or a DNA/RNA hybrid; a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide; and a use thereof for treating COVID-19.
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公开(公告)号：US20230123164A1
公开(公告)日：2023-04-20
申请号：US17907432
申请日：2021-04-12
申请人： BIONEER CORPORATION , SIRNAGEN THERAPEUTICS CORPORATION , SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人： Seung Seob SON , Tae Rim KIM , Eun Young LEE , Nam-Jun CHO , Sung Il YUN , Jun Hong PARK , Han-Oh PARK
摘要： The present invention relates to a composition using a urine sample for diagnosis of a kidney disease and, more specifically, to a urine test composition and a kit for diagnosis of a kidney disease, each comprising an agent specifically detecting amphiregulin from a urine sample, and a method for diagnosing a kidney disease by using the composition. According to the present invention, not only is there an advantage of being able to conveniently diagnose a kidney disease in a non-invasive manner using a urine sample for a kidney disease to which early diagnosis is important, but also the application of the present invention to a patient diagnosed with chronic kidney disease can advantageously predict the plausibility of progression into end-stage renal disease in advance.
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