公开(公告)号：US20180065103A1

公开(公告)日：2018-03-08

申请号：US15698350

申请日：2017-09-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： Eric Schopf ,  Melissa Moore ,  R. Michael van Dam ,  Brandon Maraglia ,  Alexander Hsiao

IPC: B01J19/00 ,  B01J19/24

CPC classification number: B01J19/004 ,  A61K2121/00 ,  B01J19/24 ,  B01J2219/00164 ,  B01J2219/00191 ,  G21F7/04 ,  G21G1/0005 ,  G21G4/08

Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.

公开(公告)号：US10589250B2

公开(公告)日：2020-03-17

申请号：US15698350

申请日：2017-09-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： Eric Schopf ,  Melissa Moore ,  R. Michael van Dam ,  Brandon Maraglia ,  Alexander Hsiao

IPC: B01J19/00 ,  B01J19/24 ,  G21G4/08 ,  G21G1/00 ,  G21F7/04

Abstract: A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.

公开(公告)号：US10473668B2

公开(公告)日：2019-11-12

申请号：US15315369

申请日：2015-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： R. Michael Van Dam ,  Melissa Moore ,  Brandon Maraglia ,  Daniel Thompson

IPC: G01N33/60 ,  A61B6/03 ,  A61B6/00 ,  G21H5/02 ,  G21G1/00 ,  G21F5/015

Abstract: A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.

公开(公告)号：US20170102391A1

公开(公告)日：2017-04-13

申请号：US15315369

申请日：2015-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SOFIE BIOSCIENCES, INC.

Inventor： R. Michael Van Dam ,  Melissa Moore ,  Brandon Maraglia ,  Daniel Thompson

IPC: G01N33/60 ,  G21G1/00 ,  G21H5/02 ,  A61B6/03 ,  A61B6/00

CPC classification number: G01N33/60 ,  A61B6/037 ,  A61B6/48 ,  A61B6/542 ,  C07B59/00 ,  G21F5/015 ,  G21G1/0005 ,  G21H5/02

Abstract: A self-shielded, bench-top radiochemistry system, including a radioactive isotope dispensing module configured to draw an isotope out of a vial and dispense one or more metered doses of the isotope to a concentration module that concentrates the metered dose into a droplet amount of isotope and a synthesizer module that delivers the droplet amount of isotope along with one or more reagents to an electrowetting on dielectrics (EWOD) chip to produce a radiolabeled molecule.