公开(公告)号：US20070092558A1

公开(公告)日：2007-04-26

申请号：US11551437

申请日：2006-10-20

Applicant: George Heavner ,  Marian Nakada ,  Sam Wu

Inventor： George Heavner ,  Marian Nakada ,  Sam Wu

IPC: A61K31/704 ,  A61K9/127

CPC classification number: A61K9/127 ,  A61K9/1271 ,  A61K31/704 ,  A61K47/62 ,  A61K47/6911

Abstract: Methods of preparing targeting ligand bound avidin-lipid vesicles for use in preparing a targeted, therapeutic liposome composition are disclosed. Each vesicle comprises an avidin molecule coupled to the polymer-conjugated biotin which retains multiple free site biotin-binding sites such that the vesicle may be used to further couple a biotinylated-targeting ligand.

Abstract translation: 公开了制备用于制备靶向治疗脂质体组合物的靶向配体结合的亲和素 - 脂质囊泡的方法。 每个囊泡包含与聚合物缀合的生物素偶联的抗生物素蛋白分子，其保留多个自由位点生物素结合位点，使得囊泡可用于进一步连接生物素化靶向配体。

公开(公告)号：US20050084491A1

公开(公告)日：2005-04-21

申请号：US10873848

申请日：2004-06-22

Applicant: David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

Inventor： David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

IPC: A61K38/04 ,  A61K39/395 ,  C07K20060101 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  C12P21/04 ,  C12Q1/68

CPC classification number: C07K7/06 ,  C07K14/70557

Abstract: The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.

Abstract translation: 本发明涉及在肿瘤学应用中具有治疗活性的α融合整联蛋白的拮抗剂，以及使用与已证实具有抗肿瘤活性的已知单克隆抗体竞争αV-整联蛋白结合的肽来选择此类拮抗剂的方法。 要求保护的肽表示存在于治疗性抗体选择性结合的配体上的构象表位或模拟表位。

公开(公告)号：US20090323351A1

公开(公告)日：2009-12-31

申请号：US12164191

申请日：2008-06-30

Applicant: Che-Kai Chen ,  Yao-Hung Wong ,  Sam Wu

Inventor： Che-Kai Chen ,  Yao-Hung Wong ,  Sam Wu

IPC: F21V7/00

CPC classification number: F21V23/009 ,  F21K9/68 ,  F21V29/74 ,  F21Y2115/10

Abstract: A lamp structure provided comprises: a slim light emitting source including at least one LED packaged on a multilayered printed circuit board type aluminum base; a funnel-shaped reflector being concaved toward a center thereof and defined with at least one hole for partially accommodating the LED, and an inner surface of the reflector being coated to form a light reflecting surface; a flat lens whose surface being treated with sand blast; a lamp housing with a receiving chamber for accommodation of the slim light emitting source, the reflector, the flat lens, and a driver, the lamp housing being formed with a plurality of heat dissipation fins; and the driver inserted in the other end of the receiving chamber of the lamp and having a positive and negative leads connected to the slim light emitting source for enabling it to produce light.

Abstract translation: 提供的灯结构包括：细长发光源，包括封装在多层印刷电路板型铝基底上的至少一个LED; 漏斗状反射器朝向其中心凹陷并且限定有用于部分容纳LED的至少一个孔，并且反射器的内表面被涂覆以形成光反射表面; 表面用喷砂处理的平板透镜; 具有用于容纳所述细长发光源，所述反射器，所述平坦透镜和驱动器的接收室的灯壳体，所述灯壳体形成有多个散热翅片; 并且驱动器插入灯的接收室的另一端并且具有连接到细长发光源的正极和负极以使其能够产生光。

公开(公告)号：US20070235149A1

公开(公告)日：2007-10-11

申请号：US11392271

申请日：2006-03-28

Applicant: Tomasz Hillar ,  Michal Trzaskowski ,  Urszula Kiszkiel ,  Czeslaw Trzaskowski ,  Sam Wu

Inventor： Tomasz Hillar ,  Michal Trzaskowski ,  Urszula Kiszkiel ,  Czeslaw Trzaskowski ,  Sam Wu

IPC: E05F15/00

CPC classification number: E05F15/41 ,  E05F15/686 ,  E05Y2201/654 ,  E05Y2201/668 ,  E05Y2400/337 ,  E05Y2600/458 ,  E05Y2900/106

Abstract: A door opening system includes a power transmission mechanism, a trolley, and a connecting arm. The power transmission mechanism includes a motor, a drive wheel driven rotatably by the motor, an indirect wheel, and a tension wheel. A transmission rope is trained on the drive, indirect and tension wheels in a closed loop such that parts of the transmission rope extend along a spiral path on the drive and indirect wheels, and do not contact each other, and such that rotation of the drive wheel drives the indirect and tension wheels rotatably. The trolley is coupled to the transmission rope, and is disposed between the indirect and tension wheels of the power transmission mechanism. The connecting arm has a first end coupled to the trolley, and a second end adapted to be coupled to the garage door.

Abstract translation: 门开启系统包括动力传递机构，手推车和连接臂。 动力传递机构包括马达，由马达可旋转地驱动的驱动轮，间接轮和张力轮。 在闭合回路中的驱动，间接和张紧轮上训练传动绳，使得传动绳的部分沿着驱动器和间接轮上的螺旋路径延伸，并且不会彼此接触，并且使得驱动器的旋转 轮子可旋转地驱动间接和张紧轮。 手推车耦合到传动绳索，并且设置在动力传递机构的间接轮和张紧轮之间。 连接臂具有联接到台车的第一端和适于联接到车库门的第二端。

公开(公告)号：US08782081B2

公开(公告)日：2014-07-15

申请号：US13105016

申请日：2011-05-11

Applicant: Mark Zhenguo Guan ,  Sam Wu

Inventor： Mark Zhenguo Guan ,  Sam Wu

IPC: G06F17/30

CPC classification number: G06F17/30389 ,  G06F17/3056

Abstract: A database query template and metadata mapping provide an end-user to generate customized database reports via a user interface. The parameters and data available to the end-user can be modified by editing the database query template and metadata mapping without modifications of the underlying system. A database query template includes query language keywords, variables, and template-tokens and defines the metrics, dimensions, data comparisons, filters, and aggregations available to an end-user. Template tokens include restriction tokens for comparing and filtering data, options-section-tokens for defining and omitting sections of the query template, and descriptor tokens for identifying dimensions and metrics of the database. The database query template is transformed into a database query based on values input by a user. The metadata mapping associates the variables of the database query template to the database data model and can include data constraints for validation of user input.

Abstract translation: 数据库查询模板和元数据映射提供最终用户通过用户界面生成定制的数据库报告。 可以通过编辑数据库查询模板和元数据映射来修改最终用户可用的参数和数据，而不会修改底层系统。 数据库查询模板包括查询语言关键字，变量和模板令牌，并定义最终用户可用的指标，维度，数据比较，过滤器和聚合。 模板令牌包括用于比较和过滤数据的限制令牌，用于定义和省略查询模板的部分的选项部分标记以及用于识别数据库的维度和度量的描述符令牌。 基于用户输入的值将数据库查询模板转换为数据库查询。 元数据映射将数据库查询模板的变量与数据库数据模型相关联，并且可以包括用于验证用户输入的数据约束。

公开(公告)号：US07365154B2

公开(公告)日：2008-04-29

申请号：US10873848

申请日：2004-06-22

Applicant: David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

Inventor： David Shealy ,  Sam Wu ,  Yan Chen ,  Audrey Baker

IPC: A61K38/04

CPC classification number: C07K7/06 ,  C07K14/70557

Abstract: The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.

Abstract translation: 本发明涉及在肿瘤学应用中具有治疗活性的α融合整联蛋白的拮抗剂，以及使用与已证实具有抗肿瘤活性的已知单克隆抗体竞争αV-整联蛋白结合的肽来选择此类拮抗剂的方法。 要求保护的肽表示存在于治疗性抗体选择性结合的配体上的构象表位或模拟表位。

公开(公告)号：US20120290620A1

公开(公告)日：2012-11-15

申请号：US13105016

申请日：2011-05-11

Applicant: Mark Zhenguo Guan ,  Sam Wu

Inventor： Mark Zhenguo Guan ,  Sam Wu

IPC: G06F17/30

CPC classification number: G06F17/30389 ,  G06F17/3056

Abstract: A database query template and metadata mapping provide an end-user to generate customized database reports via a user interface. The parameters and data available to the end-user can be modified by editing the database query template and metadata mapping without modifications of the underlying system. A database query template includes query language keywords, variables, and template-tokens and defines the metrics, dimensions, data comparisons, filters, and aggregations available to an end-user. Template tokens include restriction tokens for comparing and filtering data, options-section-tokens for defining and omitting sections of the query template, and descriptor tokens for identifying dimensions and metrics of the database. The database query template is transformed into a database query based on values input by a user. The metadata mapping associates the variables of the database query template to the database data model and can include data constraints for validation of user input.

Abstract translation: 数据库查询模板和元数据映射提供最终用户通过用户界面生成定制的数据库报告。 可以通过编辑数据库查询模板和元数据映射来修改最终用户可用的参数和数据，而不会修改底层系统。 数据库查询模板包括查询语言关键字，变量和模板令牌，并定义最终用户可用的指标，维度，数据比较，过滤器和聚合。 模板令牌包括用于比较和过滤数据的限制令牌，用于定义和省略查询模板的部分的选项部分标记以及用于识别数据库的维度和度量的描述符令牌。 基于用户输入的值将数据库查询模板转换为数据库查询。 元数据映射将数据库查询模板的变量与数据库数据模型相关联，并且可以包括用于验证用户输入的数据约束。

公开(公告)号：US07824077B2

公开(公告)日：2010-11-02

申请号：US12164191

申请日：2008-06-30

Applicant: Che-Kai Chen ,  Yao-Hung Wong ,  Sam Wu

Inventor： Che-Kai Chen ,  Yao-Hung Wong ,  Sam Wu

IPC: F21V29/00

CPC classification number: F21V23/009 ,  F21K9/68 ,  F21V29/74 ,  F21Y2115/10

Abstract: A lamp structure has a slim light emitting source including at least one LED packaged on a multilayered printed circuit board type aluminum base. A funnel-shaped reflector is concaved toward a center thereof and defined with at least one hole for partially accommodating the LED. An inner surface of the reflector is coated to form a light reflecting surface. A flat lens includes a surface being treated with sand blast. A lamp housing has a receiving chamber for accommodation of the slim light emitting source, the reflector, the flat lens, and a driver. The lamp housing is formed with a plurality of heat dissipation fins. The driver is inserted in the other end of the receiving chamber of the lamp housing and has positive and negative leads connected to the slim light emitting source for enabling it to produce light.

Abstract translation: 灯结构具有纤细的发光源，其包括封装在多层印刷电路板型铝基底上的至少一个LED。 漏斗状反射器朝向其中心凹陷并且限定有用于部分容纳LED的至少一个孔。 反射器的内表面被涂覆以形成光反射表面。 平面透镜包括用喷砂处理的表面。 灯壳体具有用于容纳超薄发光源，反射器，平坦透镜和驱动器的容纳室。 灯壳体形成有多个散热片。 驱动器插入灯壳的接收室的另一端，并且具有连接到细长发光源的正极和负极以使其能够产生光。

公开(公告)号：US20070234050A1

公开(公告)日：2007-10-04

申请号：US11398296

申请日：2006-04-04

Applicant: Tomasz Hillar ,  Michal Trzaskowski ,  Urszula Kiszkiel ,  Czeslaw Trzaskowski ,  Sam Wu

Inventor： Tomasz Hillar ,  Michal Trzaskowski ,  Urszula Kiszkiel ,  Czeslaw Trzaskowski ,  Sam Wu

IPC: H04L9/00

CPC classification number: G06F21/606 ,  H04L9/3226 ,  H04L9/3236 ,  H04L63/0428 ,  H04L2209/605

Abstract: A communications system includes a transmitting device for processing packets to be sent, and a receiving device for processing the transmitted packets. The transmitting device includes a first memory unit, a first communications unit, and a first processing unit coupled therebetween. The first processing unit is operable so as to compose an initial packet segment, encrypt the initial packet segment, form a transmit packet, and enable the first communications unit to transmit the transmit packet. The receiving device includes a second communications unit, a second memory unit, and a second processing unit coupled therebetween. The second processing unit is operable so as to determine if there is any error in the transmit packet, decrypt the encrypted packet segment of the transmit packet, verify the transmit packet, and process the data transmitted in the transmit packet.

Abstract translation: 通信系统包括用于处理要发送的分组的发送装置和用于处理所发送的分组的接收装置。 发送装置包括第一存储器单元，第一通信单元和耦合在其间的第一处理单元。 第一处理单元可操作以组成初始分组段，加密初始分组段，形成发送分组，并使第一通信单元能够发送传输分组。 接收设备包括第二通信单元，第二存储器单元和耦合在其间的第二处理单元。 第二处理单元可操作以确定发送分组中是否存在任何错误，解密发送分组的加密分组段，验证发送分组，以及处理在发送分组中发送的数据。