公开(公告)号：US09181334B2

公开(公告)日：2015-11-10

申请号：US14236812

申请日：2012-08-03

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  C07K16/18 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising complementarity determining regions of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising complementarity determining regions of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the same as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的互补决定区的重链可变区，以及 包含SEQ ID NO：9,10和11的互补决定区的轻链可变区和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

公开(公告)号：US09115200B2

公开(公告)日：2015-08-25

申请号：US13576969

申请日：2011-02-04

Applicant: Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

Inventor： Fumiyoshi Okano ,  Takanori Saito ,  Shinichi Kobayashi ,  Takayoshi Ido ,  Yoshinori Narita

IPC: C07K16/00 ,  C12P21/08 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/3053 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/34

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。

公开(公告)号：US09030449B2

公开(公告)日：2015-05-12

申请号：US11620071

申请日：2007-01-05

Applicant: Shinichi Kobayashi ,  Fusashi Kimura ,  Atsunari Tsuda ,  Yuki Okuhara

Inventor： Shinichi Kobayashi ,  Fusashi Kimura ,  Atsunari Tsuda ,  Yuki Okuhara

IPC: G09G5/00 ,  G09G3/36

CPC classification number: G09G3/3611 ,  G09G2330/06 ,  G09G2370/08

Abstract: An electro-optical device includes: a display portion that displays images; a power source portion; a converter that has an antenna receiving wireless signals including display controlling signals and image signals from the external based on a wireless transmission method and that converts the wireless signals received from the antenna into wire signals; and a driving circuit that is electrically connected to the power source portion and the converter, respectively, to display the images on the display portion based on the power supplied from the power source portion and the image signals and the display controlling signals output from the converter.

Abstract translation: 电光装置包括：显示图像的显示部; 电源部分; 转换器，其具有基于无线传输方法从天线接收包括显示控制信号和图像信号的无线信号的天线，并且将从天线接收的无线信号转换成有线信号; 以及驱动电路，其分别电连接到电源部分和转换器，以基于从电源部分提供的电力和图像信号以及从转换器输出的显示控制信号在显示部分上显示图像 。

公开(公告)号：US08937160B2

公开(公告)日：2015-01-20

申请号：US13577212

申请日：2011-02-04

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US08828398B2

公开(公告)日：2014-09-09

申请号：US13576953

申请日：2011-02-04

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: A61K39/395

CPC classification number: C07K16/30 ,  A61K39/395 ,  C07K14/4748 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US08803764B2

公开(公告)日：2014-08-12

申请号：US13418650

申请日：2012-03-13

Applicant: Shinichi Kobayashi

Inventor： Shinichi Kobayashi

IPC: G09G5/00 ,  G09G3/00 ,  G09G3/34

CPC classification number: G09G5/10 ,  G02B27/0172 ,  G02B2027/0178 ,  G09G3/003 ,  G09G3/3406 ,  G09G5/37

Abstract: A head-mount type display device adapted to make a user visually recognize a virtual image includes an image light generation section adapted to generate image light representing an image using image data and then emit the image light, a light guide section adapted to guide the image light, which is emitted, to eyes of the user, a receiving section adapted to receive the image data, and a control section, which is connected to the receiving section, controls image display by the image light generation section, and has a transmitting section adapted to transmit the image data to the receiving section. The control section controls luminance of the image light generation section so as to degrade visibility of the virtual image for a predetermined period of time in a case in which a disturbance in data communication between the transmitting section and the receiving section is presumed.

Abstract translation: 适于使用户可视地识别虚像的头戴式显示装置包括适于使用图像数据生成表示图像的图像光然后发射图像光的图像光生成部，适于引导图像的导光部 发射到用户的眼睛的光，适于接收图像数据的接收部分，以及连接到接收部分的控制部分，控制图像光生成部分的图像显示，并且具有发送部分 适于将图像数据发送到接收部分。 在假设发送部分和接收部分之间的数据通信的干扰的情况下，控制部分控制图像光发生部分的亮度，以使虚像的可见度降低预定的时间段。

公开(公告)号：US20140193434A1

公开(公告)日：2014-07-10

申请号：US14236795

申请日：2012-08-03

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Yoshitaka Minamida ,  Takanori Saito

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/732 ,  A61K2300/00

Abstract: It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.

Abstract translation: 旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。 本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区 包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

公开(公告)号：US08646649B2

公开(公告)日：2014-02-11

申请号：US13406951

申请日：2012-02-28

Applicant: Shinichi Kobayashi

Inventor： Shinichi Kobayashi

IPC: B65D83/08 ,  B65H3/00 ,  B65G59/02

CPC classification number: A45C11/18

Abstract: In order to provide a card case in which cards can be securely discharged one by one to the last one, it comprises a storage case which has a card insertion inlet and a card discharging opening, can accommodate several cards inside and comprises a lower case and an upper case; a card push-up piece for pushing up the stored cards as a whole toward the upper case; a card discharging unit with a component with a locking part for locking the uppermost one of the several cards and provided on the upper case so as to be slidable toward the card discharging opening; a guide part provided close to the card discharging opening so as to incline the tip of the card obliquely downward; and a stopper provided close to the card discharging opening so as to prevent the second and lower cards (from the uppermost one) of the several cards from being pushed out of the card discharging opening.

Abstract translation: 为了提供卡可以一个接一个地牢固地排放到最后一个的卡盒，它包括具有卡插入口和卡排出口的存储盒，可以容纳几个卡在内部，并且包括下壳体和 大写字母 用于将存储的卡作为整体朝向上壳体推出的卡片上推片; 卡片排出单元，其具有带有锁定部件的部件，用于锁定多个卡片中的最上面的一个，并设置在上壳体上，以便可朝卡片排出口滑动; 引导部分靠近卡片排出口设置，以使卡片的尖端倾斜向下倾斜; 以及设置在卡排出口附近的止动件，以防止多张卡片中的第二卡片和下卡片（从最上面的卡片）被推出卡片排出口。

公开(公告)号：US08542487B2

公开(公告)日：2013-09-24

申请号：US13224634

申请日：2011-09-02

Applicant: Shinichi Kobayashi

Inventor： Shinichi Kobayashi

IPC: H05K7/20

CPC classification number: H05K7/20572 ,  H05K7/20145

Abstract: A mounting device includes a housing for accommodating electronic units, a fan for sending cooling air to the electronic units and air flow control devices for controlling flow of the cooling air. Each air flow control device includes a first panel having at least one opening for the cooling air to pass therethrough, a second panel, slidably provided to overlap the first panel, for opening or closing the opening of the first panel, a driving force generation mechanism provided in the airflow path for cooling air and having an air receiving member for receiving an air pressure of the cooling air, the driving force generation mechanism for generating a driving force corresponding to the air pressure received by the air receiving member and a link mechanism, for receiving the driving force generated by the driving force generation mechanism and for providing a driving force that slides the second panel.

Abstract translation: 安装装置包括用于容纳电子单元的壳体，用于向电子单元发送冷却空气的风扇和用于控制冷却空气流动的气流控制装置。 每个气流控制装置包括具有用于冷却空气通过的至少一个开口的第一面板，可滑动地设置成与第一面板重叠的第二面板，用于打开或关闭第一面板的开口;驱动力产生机构 设置在用于冷却空气的气流通道中并具有用于接收冷却空气的空气压力的空气接收构件，用于产生与由空气接收构件和连杆机构接收的空气压力相对应的驱动力的驱动力产生机构， 用于接收由驱动力产生机构产生的驱动力并提供滑动第二面板的驱动力。

公开(公告)号：US20130045210A1

公开(公告)日：2013-02-21

申请号：US13577212

申请日：2011-02-04

Applicant: Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。