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    Canine distemper virus vaccine
    4.
    发明授权
    Canine distemper virus vaccine 失效
    犬瘟热病毒疫苗

    公开(公告)号：US4990367A

    公开(公告)日：1991-02-05

    申请号：US463763

    申请日：1990-01-12

    申请人： Edmund P. Bass ,  William H. Kelsey ,  Michael D. McFarland

    发明人： Edmund P. Bass ,  William H. Kelsey ,  Michael D. McFarland

    IPC分类号： A61K39/175

    CPC分类号： A61K39/175 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2760/18434

    摘要： A vaccine composition for animals susceptible to infection by canine distemper virus. The vaccine comprises a small but immunologically effective amount of an inactivated canine distemper virus in combination with a non-toxic pharmaceutically acceptable immunologic adjuvant. A preferred method of inactivation of canine distemper virus by either exposure of the virus to an inactivating effective amount of binary ethyleneimine or alternatively exposure of the virus to long wavelength ultraviolet light in the presence of a furocoumarin.

    摘要翻译： 一种易受犬瘟热病毒感染的动物的疫苗组合物。 疫苗包含小的但免疫有效量的灭活的犬瘟热病毒与无毒的药学上可接受的免疫佐剂组合。 通过将病毒暴露于灭活有效量的二元乙烯亚胺或在呋喃香豆素存在下将该病毒替代地暴露于长波长紫外光，来灭活犬瘟热病毒的优选方法。

    Cryopreservation bag assembly for mammalian cell lines
    6.
    发明授权
    Cryopreservation bag assembly for mammalian cell lines 有权

    公开(公告)号：US06670175B2

    公开(公告)日：2003-12-30

    申请号：US10143194

    申请日：2002-05-09

    申请人： De Qian Wang ,  Bruce Gardner ,  Rudiger Heidemann ,  Mokhtar Mered ,  William H. Kelsey

    发明人： De Qian Wang ,  Bruce Gardner ,  Rudiger Heidemann ,  Mokhtar Mered ,  William H. Kelsey

    IPC分类号： C12M100

    CPC分类号： A61J1/10 ,  C12M45/22 ,  C12M47/20 ,  Y10S128/24

    摘要： The invention is a novel cell freezing and storage bag assembly and method for using the assembly in the seed train expansion of mammalian cells. The bag is constructed principally of polytetrafluoroethylene fabric. The bag is designed to hold enough cells that a bioreactor can be inoculated directly. The bag is designed to be filled to a fraction of its maximum capacity so that the cell suspension has a very thin cross-section (less than about 10 millimeters). The bag design includes a transfer set that can be sterilely welded to the source of the mammalian cells. This sterile-weldable transfer set allows the bags to be filled quickly with minimal risk of contamination. In the method, once each bag is filled, it is sealed below the connection with the transfer set and the bag is cut “above” the new seal (on the same side of the seal as the transfer set). When a bioreactor is to be inoculated, the contents of the bag are drained via a sterile-weldable inoculation line. During freezing and storage, the inoculation line is protected from mechanical damage.

    Multivalent felv-infected feline vaccine
    7.
    发明授权
    Multivalent felv-infected feline vaccine 失效
    多价felv感染猫科动物疫苗

    公开(公告)号：US5374424A

    公开(公告)日：1994-12-20

    申请号：US284309

    申请日：1988-12-14

    申请人： William H. Kelsey ,  Edmund P. Bass

    发明人： William H. Kelsey ,  Edmund P. Bass

    IPC分类号： C12N5/06 ,  A61K39/00 ,  A61K39/12 ,  C07K14/15 ,  C12N7/02 ,  C12N9/06 ,  C12Q1/68 ,  C12N7/00

    CPC分类号： C07K14/005 ,  C12N7/00 ,  C12N9/0028 ,  C12Q1/6895 ,  A61K39/00 ,  C12N2740/13022 ,  C12N2740/13051 ,  Y10S424/819

    摘要： A multivalent FeLV-infected feline vaccine composed of (1) a small but immunologically effective amount of inactivated feline leukemia virus; (2) a small but effective amount of an inactivated virus selected from the group consisting of Feline Rhinotracheitis Virus, Feline Calici Virus and Feline Panleukopenia Virus; and (3) a pharmaceutically acceptable immunologica adjuvant. Components (1) and (2) may be inactivated by any of the known techniques. The inactivated feline leukemia virus must be from subgroup A and is the Rickard isolate of the virus designated FeLV-A.sub.R1. This combination vaccine is effective in preventing Viremia, leukemia-associated syndromes, and deaths in cats caused by Feline Leukemia Virus, Feline Rhinotracheitis Virus, Feline Calici Virus and Feline Panleukemia Virus infections.

    摘要翻译： 一种多价FeLV感染的猫科动物疫苗，由（1）小但免疫有效量的灭活猫科白血病病毒组成; （2）小量但有效量的选自猫流感鼻炎病毒，猫科动物病毒和猫泛白细胞减少病毒的灭活病毒; 和（3）药学上可接受的免疫佐剂。 组分（1）和（2）可以通过任何已知技术灭活。 灭活的猫白血病病毒必须来自A亚组，是名为FeLV-AR1的病毒的Rickard分离株。 这种联合疫苗有效地预防由猫白血病病毒，猫鼻气管炎病毒，猫卡里奇病毒和猫白血病病毒感染引起的病毒血症，白血病相关综合征和猫死亡。