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1.发明申请公开(公告)号：US20140219979A1
公开(公告)日：2014-08-07
申请号：US14221887
申请日：2014-03-21
Inventor： Irun R. Cohen , Alexandra Zanin-Zhorov , Guy Tal , Francisco Quintana , Meirav Pisner , Ofer Lider
CPC classification number: A61K38/1709 , A61K35/17 , A61K39/0008 , A61K2035/124 , A61K2039/5158 , A61K2039/53 , C12N5/0636 , C12N2501/07
Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.
Abstract translation: 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。
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公开(公告)号：US20250092158A1
公开(公告)日：2025-03-20
申请号：US18832710
申请日：2022-08-04
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Deborah FASS , Sarel FLEISHMAN , Lev KHMELNITSKY , Ariel TENNENHOUSE
IPC: C07K16/40 , A61K39/00 , A61K47/68 , G01N33/573
Abstract: The present invention provides humanized monoclonal antibodies that specifically recognize human QSOX1 and inhibit its activity. The humanized antibodies of the present invention were designed following in-silico selection of specific variable region segments, based on their energy scores, and were produced and confirmed to function properly in binding and inhibiting human QSOX1. The present invention further provides pharmaceutical compositions comprising the humanized antibodies and methods for their use in cancer therapy and diagnosis.
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公开(公告)号：US12232496B2
公开(公告)日：2025-02-25
申请号：US17040227
申请日：2019-03-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD
Inventor： Asaph Aharoni , Elisa Korenblum
IPC: A01N63/20 , A01G29/00 , A01N63/38 , A61K36/185 , A61K36/81 , C07D305/14 , C07J17/00
Abstract: Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.
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公开(公告)号：US20250051833A1
公开(公告)日：2025-02-13
申请号：US18721921
申请日：2022-12-26
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Sergey N. SEMENOV , Ekaterina V. SKORB
IPC: C12Q1/6834 , C12Q1/6876
Abstract: Provided herein a supramolecular assembly comprising a solid porous particle comprising a single-stranded polynucleotide encapsulated by non-covalent organic structure. Specifically, the non-covalent organic structure is melamine-cyanurate, and the single-stranded polynucleotide is ssDNA or ssRNA.
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公开(公告)号：US20250032566A1
公开(公告)日：2025-01-30
申请号：US18713665
申请日：2022-12-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rotem SOREK , Erez YIRMIYA , Azita LEAVITT , Gil AMITAI , Jeremy Elliot GARB
Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.
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Patent Agency Ranking
公开(公告)号：US12198012B2
公开(公告)日：2025-01-14
申请号：US18299821
申请日：2023-04-13
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: A quantum computing system, method, and computer readable medium involves initializing a state of a resonator-coupled quantum emitter having at least four levels arranged in an N-configuration, the N-configuration having a first ground state, a second ground state, a first excited state and a second excited state. A frequency of a first transition between the first ground state and the first excited state is tuned, a frequency of a second transition between the second ground state and the second excited state is tuned, and a frequency of a third transition between the second ground state and the first excited state is tuned. A plurality of photons are fed at a frequency corresponding to the frequency of the second transition, thereby entangling the plurality of photons to the resonator-coupled quantum emitter. Likewise, a photon at a frequency corresponding to the frequency of at least one of the first transition or the third transition is fed, thereby mapping a state of the resonator-coupled quantum emitter into a photon.
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公开(公告)号：US12190206B2
公开(公告)日：2025-01-07
申请号：US18300644
申请日：2023-04-14
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: A quantum computing system, method and computer readable medium involve a vacuum enclosure for sustaining a vacuum below 10−3 millibar, optical resonators tuned to a resonance of an alkali atom, and a trapping laser for maintaining the alkali atom within a mode of the optical resonators. An atom excitation laser induces photon emissions, a plurality of waveguides couple photons to and from the optical resonators, and a plurality of detectors detect a presence or absence of an atom-resonator coupling. A processor receives output signals from the detectors and controls optical switches for switching between two or more of the plurality of waveguides.
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公开(公告)号：US20240402165A1
公开(公告)日：2024-12-05
申请号：US18688809
申请日：2022-09-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Ulyana SHIMANOVICH , Aleksei V. SOLOMONOV , Alexander TESLER
IPC: G01N33/543
Abstract: This invention provides nanostructures comprising a base. and nano-protrusions attached to the base. The invention further provides arrays of such nanostructures on substrates. Also provided by this invention are analysis and catalysis. separation and purification systems and methods. comprising or making use of the novel nanostructures. Particles and films comprising nano-protrusions are included in this invention as well.
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公开(公告)号：US20240368790A1
公开(公告)日：2024-11-07
申请号：US18686465
申请日：2022-08-31
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Igor LUBOMIRSKY , Valery KAPLAN
Abstract: Provided herein is an apparatus for electrolytic atomic hydrogen decrepitation and methods of use thereof.
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公开(公告)号：US20240352538A1
公开(公告)日：2024-10-24
申请号：US18764250
申请日：2024-07-04
Applicant: Yeda Research and Development Co. Ltd. , SeqLL Inc.
Inventor： Efrat SHEMA-YAACOBY , Erez NIR , Vadim FEDYUK , Ekaterina ANDREISHCHEVA , Daniel JONES , Abhijeet SHINDE
IPC: C12Q1/6886 , C12Q1/6804
CPC classification number: C12Q1/6886 , C12Q1/6804 , C12Q2600/156
Abstract: A method of analyzing nucleosomes is provided. The method comprising: (a) isolating a plurality of nucleosome molecules from a biological sample; (b) enzymatically linking adenine nucleotides to free DNA ends of the plurality of nucleosome molecules, wherein at least a portion of the adenine nucleotides comprises a label, such that the plurality of nucleosome molecules become attached to a labeled poly(A) tail; (c) hybridizing the plurality of nucleosome molecules attached to the labeled poly(A) tail to a solid support coated with poly(T); and (d) imaging the solid support, whereby the plurality of nucleosome molecules are visualized.
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