公开(公告)号：US20200071312A1

公开(公告)日：2020-03-05

申请号：US16552554

申请日：2019-08-27

Applicant: National Health Research Institutes ,  Academia Sinica

Inventor： Chih-Hao Chen ,  Chuan Shih ,  Chiung-Tong Chen ,  Hwei-Jiung Wang ,  Kai-Fa Huang

IPC: C07D417/14 ,  C07D403/14 ,  A61P25/28 ,  C07D413/14

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：US09229012B2

公开(公告)日：2016-01-05

申请号：US13942529

申请日：2013-07-15

Applicant: Taipei Medical University ,  Academia Sinica

Inventor： Wei-Chung Yang ,  Hwei-Jiung Wang ,  Shui-Tsung Chen ,  Ken-Fen Lu ,  Ming-Chi Peng

IPC: G01N33/53 ,  G01N33/68 ,  C07K16/18 ,  C07K16/38

CPC classification number: G01N33/6893 ,  C07K16/18 ,  C07K16/38 ,  C07K2317/34 ,  G01N2333/8125 ,  G01N2800/364

Abstract: Provided herein are monoclonal antibodies with a high binding affinity to isoforms of alpha 1-antitrypsin (A1AT), hybridoma cells producing the same, and their uses in diagnosing and/or detecting endometriosis from a serum sample of a subject suspicious of having endometriosis or a subject under health examination.

Abstract translation: 本文提供对α1-抗胰蛋白酶（A1AT）的同种型具有高结合亲和力的单克隆抗体，产生相同的杂交瘤细胞的单克隆抗体及其在诊断和/或检测可疑患有子宫内膜异位症的受试者血清样品中的子宫内膜异位症的用途 受检体检。

公开(公告)号：US10752673B2

公开(公告)日：2020-08-25

申请号：US15619835

申请日：2017-06-12

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Hong-Sen Chen ,  Chung-Ming Yu ,  Shin-Chen Hou ,  Wei-Ying Kuo ,  Yi-Kai Chiu ,  Yueh-Liang Tsou ,  Hung-Ju Hsu ,  Hwei-Jiung Wang ,  Shih-Hsien Chuang ,  Chao-Pin Lee

IPC: A61K39/395 ,  A61K39/00 ,  A61K39/02 ,  C07K16/00 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32 ,  C07K19/00

Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

公开(公告)号：US10584120B1

公开(公告)日：2020-03-10

申请号：US16552554

申请日：2019-08-27

Applicant: National Health Research Institutes ,  Academia Sinica

Inventor： Chih-Hao Chen ,  Chuan Shih ,  Chiung-Tong Chen ,  Hwei-Jiung Wang ,  Kai-Fa Huang

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P25/28 ,  C07D409/14 ,  A61K45/06

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

公开(公告)号：US20230097801A1

公开(公告)日：2023-03-30

申请号：US17829917

申请日：2022-06-01

Applicant: National Health Research Institutes ,  Academia Sinica

Inventor： Chih-Hao Chen ,  Wan-Ching Yen ,  Teng-Kuang Yeh ,  Chiung-Tong Chen ,  Hwei-Jiung Wang ,  Kai-Fa Huang

IPC: A61K31/41 ,  A61K31/427 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/381 ,  A61P35/00 ,  A61K45/06

Abstract: Disclosed are methods for treatments of conditions involving CD47 upregulation using a compound of formula (I): Variables R1-R9, X, and Het are defined therein. Also disclosed are methods for increasing phagocytosis of a cell using such a compound and pharmaceutical compositions each containing the compound and an anti-cancer agent.

公开(公告)号：US11434277B2

公开(公告)日：2022-09-06

申请号：US16757460

申请日：2018-10-19

Applicant: ACADEMIA SINICA

Inventor： An-Suei Yang ,  Ing-Chien Chen ,  Yi-Kai Chiu ,  Chung-Ming Yu ,  Cheng-Chung Lee ,  Chao-Ping Tung ,  Yueh-Liang Tsou ,  Yi-Jen Huang ,  Chia-Lung Lin ,  Hong-Sen Chen ,  Hwei-Jiung Wang

IPC: C07K16/00 ,  C07K16/10

Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.

公开(公告)号：US10562976B2

公开(公告)日：2020-02-18

申请号：US16166220

申请日：2018-10-22

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Wei-Ying Kuo ,  Hung-Ju Hsu ,  Hong-Sen Chen ,  Yu-Chi Chou ,  Yueh-Liang Tsou ,  Hung-Pin Peng ,  Jhih-Wei Jian ,  Chung-Ming Yu ,  Yi-Kai Chiu ,  Ing-Chein Chen ,  Chao-Ping Tung ,  Michael Hsiao ,  Hwei-Jiung Wang

IPC: A61K39/00 ,  A61K39/38 ,  A61K39/395 ,  C07K16/30 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32

Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.