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公开(公告)号：US09309522B2
公开(公告)日：2016-04-12
申请号：US13897850
申请日：2013-05-20
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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公开(公告)号：US11434277B2
公开(公告)日：2022-09-06
申请号：US16757460
申请日：2018-10-19
Applicant: ACADEMIA SINICA
Inventor： An-Suei Yang , Ing-Chien Chen , Yi-Kai Chiu , Chung-Ming Yu , Cheng-Chung Lee , Chao-Ping Tung , Yueh-Liang Tsou , Yi-Jen Huang , Chia-Lung Lin , Hong-Sen Chen , Hwei-Jiung Wang
Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.
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公开(公告)号：US10336815B2
公开(公告)日：2019-07-02
申请号：US15232819
申请日：2016-08-10
Applicant: Academia Sinica
Inventor： An-Suei Yang , Ing-Chien Chen , Chao-Ping Tung , Chung-Ming Yu
Abstract: Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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Patent Agency Ranking
公开(公告)号：US20160176952A1
公开(公告)日：2016-06-23
申请号：US15064036
申请日：2016-03-08
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
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公开(公告)号：US20130323787A1
公开(公告)日：2013-12-05
申请号：US13897850
申请日：2013-05-20
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
IPC: C12N15/73
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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公开(公告)号：US10472411B2
公开(公告)日：2019-11-12
申请号：US16409994
申请日：2019-05-13
Applicant: Academia Sinica
Inventor： An-Suei Yang , Hong-Sen Chen , Ing-Chien Chen , Chao-Ping Tung , Shin-Chen Hou , Chung-Ming Yu , Chi-Kai Yang , Yi-Kai Chiu
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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公开(公告)号：US10336816B2
公开(公告)日：2019-07-02
申请号：US15547523
申请日：2016-02-23
Applicant: Academia Sinica
Inventor： An-Suei Yang , Hong-Sen Chen , Ing-Chien Chen , Chao-Ping Tung , Shin-Chen Hou , Chung-Ming Yu , Chi-Kai Yang , Yi-Kai Chiu
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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公开(公告)号：US09951121B2
公开(公告)日：2018-04-24
申请号：US15064036
申请日：2016-03-08
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
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