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公开(公告)号：US12116407B2
公开(公告)日：2024-10-15
申请号：US17269991
申请日：2019-09-25
Applicant: Academia Sinica
Inventor： Shie-Liang Hsieh , Pei-Shan Sung , Ming-Ting Huang , An-Suei Yang , Chung-Ming Yu
CPC classification number: C07K16/2803 , A61P25/28 , A61P31/20 , A61K2039/505 , C07K2317/56 , C07K2317/76 , C07K2317/77
Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.
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公开(公告)号：US10752673B2
公开(公告)日：2020-08-25
申请号：US15619835
申请日：2017-06-12
Applicant: Academia Sinica
Inventor： An-Suei Yang , Hong-Sen Chen , Chung-Ming Yu , Shin-Chen Hou , Wei-Ying Kuo , Yi-Kai Chiu , Yueh-Liang Tsou , Hung-Ju Hsu , Hwei-Jiung Wang , Shih-Hsien Chuang , Chao-Pin Lee
Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
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公开(公告)号：US09309522B2
公开(公告)日：2016-04-12
申请号：US13897850
申请日：2013-05-20
Applicant: Academia Sinica
Inventor： An-Suei Yang , Yu-Ching Lee , Ing-Chien Chen , Chung-Ming Yu , Hung-Ju Hsu , Yi-Jen Huang , Hung-Ju Chang , Keng-Chang Tsai , Hung-Pin Peng
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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公开(公告)号：US11434277B2
公开(公告)日：2022-09-06
申请号：US16757460
申请日：2018-10-19
Applicant: ACADEMIA SINICA
Inventor： An-Suei Yang , Ing-Chien Chen , Yi-Kai Chiu , Chung-Ming Yu , Cheng-Chung Lee , Chao-Ping Tung , Yueh-Liang Tsou , Yi-Jen Huang , Chia-Lung Lin , Hong-Sen Chen , Hwei-Jiung Wang
Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.
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公开(公告)号：US10562976B2
公开(公告)日：2020-02-18
申请号：US16166220
申请日：2018-10-22
Applicant: Academia Sinica
Inventor： An-Suei Yang , Wei-Ying Kuo , Hung-Ju Hsu , Hong-Sen Chen , Yu-Chi Chou , Yueh-Liang Tsou , Hung-Pin Peng , Jhih-Wei Jian , Chung-Ming Yu , Yi-Kai Chiu , Ing-Chein Chen , Chao-Ping Tung , Michael Hsiao , Hwei-Jiung Wang
Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.
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Patent Agency Ranking
公开(公告)号：US10415033B2
公开(公告)日：2019-09-17
申请号：US16202106
申请日：2018-11-28
Applicant: Academia Sinica
Inventor： An-Suei Yang , Jhih-Wei Jian , Hong-Sen Chen , Yi-Kai Chiu , Hung-Pin Peng , Chao-Ping Tung , Chung-Ming Yu , Wei-Ying Kuo , Hung-Ju Hsu
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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公开(公告)号：US10336815B2
公开(公告)日：2019-07-02
申请号：US15232819
申请日：2016-08-10
Applicant: Academia Sinica
Inventor： An-Suei Yang , Ing-Chien Chen , Chao-Ping Tung , Chung-Ming Yu
Abstract: Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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公开(公告)号：US12103969B2
公开(公告)日：2024-10-01
申请号：US17266092
申请日：2018-09-25
Applicant: Academia Sinica
Inventor： Shie-Liang Hsieh , Tsung-Yu Tsai , An-Suei Yang , Chung-Ming Yu , Cheng-Yuan Peng
CPC classification number: C07K16/2803 , A61P25/28 , A61P31/20 , A61K2039/505 , C07K2317/56 , C07K2317/76 , C07K2317/77
Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.
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公开(公告)号：US10472411B2
公开(公告)日：2019-11-12
申请号：US16409994
申请日：2019-05-13
Applicant: Academia Sinica
Inventor： An-Suei Yang , Hong-Sen Chen , Ing-Chien Chen , Chao-Ping Tung , Shin-Chen Hou , Chung-Ming Yu , Chi-Kai Yang , Yi-Kai Chiu
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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公开(公告)号：US10336816B2
公开(公告)日：2019-07-02
申请号：US15547523
申请日：2016-02-23
Applicant: Academia Sinica
Inventor： An-Suei Yang , Hong-Sen Chen , Ing-Chien Chen , Chao-Ping Tung , Shin-Chen Hou , Chung-Ming Yu , Chi-Kai Yang , Yi-Kai Chiu
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
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