公开(公告)号：US20150367028A1

公开(公告)日：2015-12-24

申请号：US14719674

申请日：2015-05-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Charlotte A.E. Hauser ,  Ulung Gondo Kusumo Khoe ,  Archana Mishra

IPC: A61L27/22 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61L27/22 ,  A61K8/042 ,  A61K8/64 ,  A61K38/00 ,  A61L27/52 ,  A61L27/54 ,  A61L2430/00 ,  A61Q19/00 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06069 ,  C07K5/06104 ,  C07K5/06113 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/1008 ,  C07K5/101 ,  C07K7/06

Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming, a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly: A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.

Abstract translation: 本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的hy-ggel。 两亲性线性肽/拟肽能够形成水凝胶。 这些肽/拟肽包括具有脂族氨基酸的疏水部分和至少一种酸性，中性或碱性极性氨基酸的短亲水序列。 两亲性线性肽/拟肽是由非重复脂肪族氨基酸组成的，它们可以是L-或D-形式。 多个这样的肽/拟肽组装成超分子螺旋纤维，并在组装后形成肽水凝胶：在生理pH下在水溶液中形成相应的水凝胶，因此可用于特别是细胞培养，组织工程和药物释放。 这种刚性，生物相容性和捕获高达99.9％的水的水凝胶也非常适合于利用电子设备的应用。

公开(公告)号：US20150352220A1

公开(公告)日：2015-12-10

申请号：US14655223

申请日：2013-12-24

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Michael R. Reithofer ,  Charlotte A.E. Hauser ,  Kiat Hwa CHAN ,  Archana Mishra

IPC: A61K47/48 ,  A61K31/282

CPC classification number: A61K47/48246 ,  A61K31/282 ,  A61K31/555 ,  A61K38/08 ,  A61K47/64

Abstract: The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

Abstract translation: 本发明涉及包含具有共价连接的生物活性剂和任选的第二肽的第一肽的水凝胶。 本发明还涉及水凝胶用于递送生物活性剂或作为植入物的用途。 本发明还涉及包含该水凝胶的药物递送装置，植入物，药物或化妆品组合物。 本发明还涉及疾病的局部治疗方法以及制备第一种肽和水凝胶的方法。