公开(公告)号：US20180346626A1

公开(公告)日：2018-12-06

申请号：US15779513

申请日：2016-11-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. YING ,  Nandanan ERATHODIYIL ,  Hong WU ,  Hsi-Min CHAN

IPC: C08F220/18 ,  C08K5/09 ,  C08L33/24 ,  A61L27/34 ,  A61L27/52

Abstract: A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.

公开(公告)号：US20180355310A1

公开(公告)日：2018-12-13

申请号：US15780236

申请日：2016-11-30

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Jackie Y. YING ,  Nandanan ERATHODIYIL ,  Karthikeyan NARAYANAN ,  Andrew C.A. WAN

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  B82Y5/00 ,  B82Y30/00 ,  C12N2533/30 ,  C12N2537/00 ,  C12N2539/00

Abstract: A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.