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公开(公告)号：US20190008830A1
公开(公告)日：2019-01-10
申请号：US16039098
申请日：2018-07-18
发明人： Motoichi Kurisawa , Yongvongsoontorn Nunnarpas , Jackie Y. YING , Joo Eun CHUNG , Ki Hyun BAE , Min-Han TAN , Esther LEE
IPC分类号： A61K31/404 , C08G65/332 , C08G65/331 , A61K31/704 , A61K47/60 , C08L89/00 , C08L5/16 , C08L5/02 , C08L5/00 , C08L3/02 , C08L1/02
摘要： The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.
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公开(公告)号：US20140011227A1
公开(公告)日：2014-01-09
申请号：US13867533
申请日：2013-04-22
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , A61K35/35 , A61K35/36 , A61K47/26 , C12N5/0627 , C12N5/0666 , C12N11/10 , C12N2501/12 , C12N2501/15 , G01N33/5088
摘要： A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.
摘要翻译： 纤维结构，其包含在纤维基质内的毛囊细胞的组合。
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公开(公告)号：US20230278868A1
公开(公告)日：2023-09-07
申请号：US18008148
申请日：2021-06-02
发明人： Jackie Y. YING , Jian Liang CHEONG
IPC分类号： C01B32/158 , C01B32/914 , H01M50/431 , H01M10/052 , H01M10/058 , C01B21/06 , C01B21/082
CPC分类号： C01B32/158 , C01B32/914 , H01M50/431 , H01M10/052 , H01M10/058 , C01B21/06 , C01B21/0828 , H01M2010/0495
摘要： There is provided a coral-like composite material comprising highly dispersed conductive metal nitride, metal carbide or metal carbonitride nanoparticles on mesoporous carbon nanosheets, and a method of preparing the same. There is also provided a coating material for a modified separator of a lithium-sulfur battery comprising the coral-like composite material as described herein, a conducting carbon material and a binder, and a method of preparing the same.
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公开(公告)号：US20180346626A1
公开(公告)日：2018-12-06
申请号：US15779513
申请日：2016-11-22
发明人： Jackie Y. YING , Nandanan ERATHODIYIL , Hong WU , Hsi-Min CHAN
IPC分类号： C08F220/18 , C08K5/09 , C08L33/24 , A61L27/34 , A61L27/52
摘要： A polymeric composition comprising (i) a plurality of monomers selected from (a) a carboxylic acryloyi monomer; (b) a sulfonic acryloyi monomer; (c) an amine acryloyi monomer; (d) a hydroxyl acryloyi monomer; (e) an alkyl acryloyi monomer; and (f) a polyalkylene hydroxyl acryloyi monomer; (ii) a divalent metallic crosslinking agent; and (c) a stabilizing agent is disclosed herein. Also provided are the use of said polymeric composition as a hydrogel coating material, a method of synthesizing the polymeric composition and the use of the hydrogel material.
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公开(公告)号：US20160265029A1
公开(公告)日：2016-09-15
申请号：US15036398
申请日：2014-11-07
CPC分类号： C12Q1/686 , B01L7/52 , B01L2200/026 , B01L2200/147 , B01L2300/023 , B01L2300/024 , B01L2300/0829 , B01L2300/1822 , G01N21/251 , G01N21/253 , G01N21/78 , G01N2201/062 , G01N2201/0638 , G01N2201/0683
摘要： A colorimetric-based DNA diagnostic system which includes a detector module, a processor and a memory is provided. The detector module is disposed to record an image of a DNA sample illuminated by a light source. The memory includes computer program code which along with the memory is configured, with the processor, to perform (a) sending a signal to adjust the temperature of the DNA sample to be within an approximate temperature range over which the color of the DNA sample changes, (b) sending a signal to the detector module to capture an image of the DNA sample at defined intervals within the approximate temperature range, (c) processing the captured images to extract color information, and (d) processing the extracted color information to objectively determine a melting temperature within the approximate temperature range at which the color of the DNA sample changes.
摘要翻译： 提供了一种基于比色的DNA诊断系统，其包括检测器模块，处理器和存储器。 检测器模块设置成记录由光源照射的DNA样品的图像。 存储器包括计算机程序代码，其与存储器一起配置处理器，以执行（a）发送信号以将DNA样本的温度调节到DNA样本的颜色变化的近似温度范围内 （b）向检测器模块发送信号以在大致温度范围内以规定的间隔捕获DNA样品的图像，（c）处理所捕获的图像以提取颜色信息，以及（d）将所提取的颜色信息处理为 客观地确定在DNA样品的颜色变化的近似温度范围内的熔融温度。
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公开(公告)号：US20180355310A1
公开(公告)日：2018-12-13
申请号：US15780236
申请日：2016-11-30
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , B82Y5/00 , B82Y30/00 , C12N2533/30 , C12N2537/00 , C12N2539/00
摘要： A cell culture substrate comprising a substrate having a coating of a plurality of amine functionalized nanoparticles is disclosed. In one embodiment, the amine functionalized nanoparticle is a polymer of an acrylamide monomer, a cross-linker and an amine monomer. There is also provided a method of making the cell culture substrate either by drying the amine functionalized nanoparticles when spread onto the said substrate or by covalent linkages of the substrate with thiol terminated nanoparticles. In addition, there is provided a method of culturing stem cells on the cell culture substrate having a coating of a plurality of the amine functionalized nanoparticles thereon.
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公开(公告)号：US20170285021A1
公开(公告)日：2017-10-05
申请号：US15506964
申请日：2015-08-31
发明人： Jackie Y. YING , Yong Yeow LEE , Jianhao BAI
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , G01N33/558
摘要： This invention relates to a test strip for paper based assay, the test strip comprising a substrate addition zone for receiving a substrate and a test zone, the test zone comprising a capture agent, wherein the substrate addition zone is located upstream of the test zone. The invention 5 also relates to a paper-based enzyme assay comprising a test strip of the invention and methods of detecting the presence of an analyte in a sample using a test strip of the invention.
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公开(公告)号：US20170258926A1
公开(公告)日：2017-09-14
申请号：US15309675
申请日：2015-05-08
发明人： Motoichi KURISAWA , Yongvongsoontorn NUNNARPAS , Jackie Y. YING , Joo Eun CHUNG , Ki Hyun BAE , Min-han TAN , Esther LEE
IPC分类号： A61K9/127 , A61K31/704 , A61K31/353 , C08G65/332 , A61K9/107 , A61K31/404 , C07D405/14
CPC分类号： A61K31/404 , A61K9/107 , A61K31/353 , A61K31/704 , A61K47/10 , A61K47/48215 , A61K47/60 , B82Y5/00 , C08G65/331 , C08G65/3315 , C08G65/3317 , C08G65/3318 , C08G65/332 , C08G65/3326 , C08G65/3328 , C08G65/33396 , C08L1/02 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/16 , C08L89/00 , C08L2203/02
摘要： The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.
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9.发明申请METHOD FOR DIFFERENTIATING INDUCED PLURIPOTENT STEM CELLS INTO RENAL PROXIMAL TUBULAR CELL-LIKE CELLS 审中-公开将诱导性肺源性干细胞分化为肾小管细胞样细胞的方法公开(公告)号：US20160281062A1
公开(公告)日：2016-09-29
申请号：US15035739
申请日：2014-11-11
发明人： Daniele ZINK , Jackie Y. YING
CPC分类号： C12N5/0686 , A61K35/22 , A61K35/545 , A61L27/3604 , A61L27/3641 , A61L27/3839 , A61L27/3895 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/64 , A61L2430/26 , A61L2430/40 , C12N2501/155 , C12N2501/727 , C12N2506/45 , C12N2533/90
摘要： There is provided a method of differentiating an induced pluripotent stem cell (iPSC) into a renal proximal tubular cell (PTC)-like cell. The method comprises culturing an undifferentiated iPSC in a renal epithelial cell culture medium in the presence of one or more extracellular matrix (ECM) molecules, bone morphogenic protein 2 (BMP2) and bone morphogenic protein 7 (BMP7), for a period of from about 8 to about 10 days, under conditions sufficient to induce differentiation of the iPSC into a PTC-like cell. A cell population of differentiated PTC-like cells is also provided, as well as uses and methods of use of the cell population.
摘要翻译： 提供了将诱导多能干细胞（iPSC）分化成肾近端肾小管（PTC）样细胞的方法。 该方法包括在一个或多个细胞外基质（ECM）分子，骨形态发生蛋白2（BMP2）和骨形态发生蛋白7（BMP7）的存在下，在肾上皮细胞培养基中培养未分化的iPSC，时间为约 在足以诱导iPSC分化成PTC样细胞的条件下，8至约10天。 还提供了分化的PTC样细胞的细胞群，以及细胞群体的使用和使用方法。
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公开(公告)号：US20230282833A1
公开(公告)日：2023-09-07
申请号：US18016315
申请日：2021-07-14
发明人： Jackie Y. YING , Jian LIang CHEONG
摘要： There is provided a hydrogel binder and a method of synthesizing the same. There is also provided a free-standing electrode comprising the hydrogel binder and a method of preparing the free-standing electrode comprising the hydrogel binder. There is further provided a battery comprising the free-standing electrode as defined herein.
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