公开(公告)号：US11447547B1

公开(公告)日：2022-09-20

申请号：US16219871

申请日：2018-12-13

Applicant: Amgen Inc.

Inventor： Elaheh Binabaji ,  Chio Mui Chan ,  Hadley Krizner ,  Junfen Ma ,  Diana Woehle

IPC: C07K1/113 ,  C07K1/22 ,  C07K16/06 ,  B01D15/38 ,  C07K16/28 ,  C07K16/42

Abstract: The present disclosure relates to methods of re-oxidizing an antigen-binding protein.

公开(公告)号：US20230069095A1

公开(公告)日：2023-03-02

申请号：US17821835

申请日：2022-08-24

Applicant: AMGEN INC.

Inventor： Elaheh Binabaji ,  Chio Mui Chan ,  Hadley Krizner ,  Junfen Ma ,  Diana Woehle

IPC: C07K16/28 ,  C07K1/113 ,  C07K1/22 ,  B01D15/38 ,  C07K16/42 ,  C07K16/06

Abstract: The present disclosure relates to methods of re-oxidizing an antigen-binding protein.

公开(公告)号：US11464857B2

公开(公告)日：2022-10-11

申请号：US15902775

申请日：2018-02-22

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Sekhar Kanapuram ,  Huanchun Cui ,  Chio Mui Chan ,  Elaheh Binabaji

IPC: A61K39/395 ,  C07K16/40 ,  A61K47/18 ,  C07K1/36 ,  A61K9/00 ,  C07K1/16 ,  C07K16/06 ,  C07K16/22

Abstract: Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.

公开(公告)号：US20250163154A1

公开(公告)日：2025-05-22

申请号：US19022273

申请日：2025-01-15

Applicant: AMGEN INC.

Inventor： Junfen Ma ,  Elaheh Binabaji ,  Chio Mui Chan ,  Hadley Krizner ,  Diana Woehle

IPC: C07K16/28 ,  B01D15/38 ,  C07K1/113 ,  C07K1/22 ,  C07K16/06 ,  C07K16/42

Abstract: The present disclosure relates to methods of re-oxidizing an antigen-binding protein.