公开(公告)号：US20160152700A1

公开(公告)日：2016-06-02

申请号：US15014828

申请日：2016-02-03

Applicant: AMGEN INC.

Inventor： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC: C07K16/24

CPC classification number: C07K16/24 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

Abstract translation: 本公开提供了与抗人结合蛋白相关的组合物和方法，其结合人胸腺基质淋巴细胞生成素（TSLP），包括抗体。 在具体实施方案中，本公开提供完全人，人源化和嵌合抗TSLP抗体及其抗体的衍生物。 本公开进一步提供编码此类抗体和抗体片段及衍生物的核酸，以及制备和使用此类抗体的方法，包括治疗和预防TSLP相关炎症和纤维化病症的方法。

公开(公告)号：US10287348B2

公开(公告)日：2019-05-14

申请号：US15014828

申请日：2016-02-03

Applicant: AMGEN INC.

Inventor： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC: A61K39/00 ,  C07K16/24 ,  A61K39/395

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

公开(公告)号：US20250154241A1

公开(公告)日：2025-05-15

申请号：US19022014

申请日：2025-01-15

Applicant: AMGEN INC.

Inventor： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC: C07K16/24 ,  A61K39/00 ,  A61K39/395

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

公开(公告)号：US20160251443A1

公开(公告)日：2016-09-01

申请号：US15058738

申请日：2016-03-02

Applicant: KIRIN-AMGEN, INC.

Inventor： Joel E. Tocker ,  Jacques J. Peschon ,  David Fitzpatrick ,  James F. Smothers ,  Christopher Mehlin ,  Ai Ching Lim

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.

Abstract translation: 本发明涉及IL-17受体A（IL-17RA或IL-17R）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗IL-17受体介导的疾病的组合物和方法 一种或多种IL-17配体的活化。 本发明涉及鉴定IL-17受体A（IL-17RA或IL-17R）上的中和决定簇和与之结合的抗体。 本发明的方面还包括与本文所述的IL-17RA中和抗体竞争结合的抗体。

公开(公告)号：US20200071393A1

公开(公告)日：2020-03-05

申请号：US16406811

申请日：2019-05-08

Applicant: Amgen Inc.

Inventor： Michael R. Comeau ,  James F. Smothers ,  Bo-Rin P. Yoon ,  Christopher Mehlin

IPC: C07K16/24

Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.

公开(公告)号：US09988457B2

公开(公告)日：2018-06-05

申请号：US15048777

申请日：2016-02-19

Applicant: Amgen Inc.

Inventor： Kenneth Allan Brasel ,  James F. Smothers ,  Douglas Pat Cerretti

IPC: C07K16/28 ,  C07H21/04 ,  C07K14/715 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K14/7153 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.

公开(公告)号：US20140356355A1

公开(公告)日：2014-12-04

申请号：US14304472

申请日：2014-06-13

Applicant: Amgen Inc.

Inventor： Joel E. Tocker ,  Jacques J. Peschon ,  David Fitzpatrick ,  James F. Smothers ,  Christopher Mehlin ,  Ai Ching Lim

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to IL-17 Receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases mediated by IL-17 Receptor A activation by one or more IL-17 ligands. The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and antibodies that bind thereto. Aspects of the invention also include antibodies that compete for binding with the IL-17RA neutralizing antibodies described herein.

Abstract translation: 本发明涉及IL-17受体A（IL-17RA或IL-17R）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗IL-17受体介导的疾病的组合物和方法 一种或多种IL-17配体的活化。 本发明涉及鉴定IL-17受体A（IL-17RA或IL-17R）上的中和决定簇和与之结合的抗体。 本发明的方面还包括与本文所述的IL-17RA中和抗体竞争结合的抗体。