公开(公告)号：US20250026055A1

公开(公告)日：2025-01-23

申请号：US18903590

申请日：2024-10-01

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315 ,  B29K705/00 ,  B29L31/00

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US12128593B2

公开(公告)日：2024-10-29

申请号：US17687725

申请日：2022-03-07

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315 ,  B29K705/00 ,  B29L31/00

CPC classification number: B29C45/14598 ,  A61M5/31511 ,  B29C45/14065 ,  B29C45/14221 ,  A61M2207/00 ,  B29C2045/14155 ,  B29K2705/00 ,  B29L2031/7544

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US20210213210A1

公开(公告)日：2021-07-15

申请号：US17134630

申请日：2020-12-28

Applicant: AMGEN INC.

Inventor： Jan Jensen

IPC: A61M5/32 ,  A61M5/24 ,  A61M5/20

Abstract: Needle shield removers, drug delivery devices, and associated methods are provided that include a tubular body formed from a sheet with a closure having from a plurality of teeth extending laterally outwardly from one longitudinal edge of the sheet and a plurality of grooves extending laterally inwardly into the sheet of material from a second longitudinal edge of the sheet. The plurality of teeth are frictionally received within the plurality of grooves to thereby hold the body in a tubular configuration. The needle shield removers can further include a first plurality of barbs arrayed around a circumference of the body adjacent to a first end thereof and a second plurality of barbs arrayed around a circumference of the body adjacent to a second end thereof.

公开(公告)号：US20220281146A1

公开(公告)日：2022-09-08

申请号：US17687725

申请日：2022-03-07

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Jan Jensen

IPC: B29C45/14 ,  A61M5/315

Abstract: A method of manufacturing a plunger of a drug delivery device includes forming a plunger body. The method includes loading the plunger body into a cavity of a first molding tool of a molding system. The cavity is at least partially defined by a first molding portion and a second molding portion. The method includes coupling a second molding tool to the first molding tool to form a plurality of channels defined by grooves in the first and second molding tools, and injecting molten plastic into the plurality of channels to form an overmolded plunger body. The overmolded plunger body includes a head coupled to the first end of the plunger body and a foot coupled to the second end of the plunger body. The foot is at least partially coupled to the inner wall and the head is coupled to the outer wall of the plunger body.

公开(公告)号：US11878149B2

公开(公告)日：2024-01-23

申请号：US17036129

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Soren Forbech Skall ,  Lars Eilertsen ,  Matias Melander ,  Jan Jensen

IPC: A61M5/315 ,  A61M5/20 ,  A61M5/31 ,  A61M5/32

CPC classification number: A61M5/31536 ,  A61M5/20 ,  A61M5/3137 ,  A61M5/3157 ,  A61M5/3204 ,  A61M2205/581 ,  A61M2205/582

Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.

公开(公告)号：US20210093793A1

公开(公告)日：2021-04-01

申请号：US17036129

申请日：2020-09-29

Applicant: AMGEN INC.

Inventor： Emil Finkelstein ,  Soren Forbech Skall ,  Lars Eilertsen ,  Matias Melander ,  Jan Jensen

IPC: A61M5/315

Abstract: A drug delivery device may include a housing defining a longitudinal axis and having an opening and a drug storage container including a delivery member having an insertion end configured to extend at least partially through the opening during a delivery state. The device may also include plunger moveable toward the distal end of the drug storage container to expel a drug from the drug storage container through the delivery member, the plunger including a body portion having an inner wall defining an axial chamber and an outer wall cooperating with the inner wall to define a body thickness. The device may further include a plunger biasing member disposed at least partially within the axial chamber, the plunger biasing member configured to urge the plunger toward the distal end of the drug storage container.