公开(公告)号：US12012462B2

公开(公告)日：2024-06-18

申请号：US17046731

申请日：2019-04-10

Applicant: AMGEN INC. ,  KiTe Pharma, Inc.

Inventor： Michael John Giffin ,  Melissa Thomas ,  Christopher Murawsky ,  Ryan B. Case ,  Lawren Wu ,  Jed J. Wiltzius ,  Ruben Alvarez Rodriguez ,  Jun Feng

IPC: C07K16/30 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C12N15/86

CPC classification number: C07K16/30 ,  A61P35/00 ,  C07K14/70517 ,  C07K14/70521 ,  C12N15/86 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C12N2740/15041

Abstract: Antigen binding molecules, chimeric receptors, and engineered immune cells to DLL3 are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the DLL3 antigen binding molecules and engineered immune cells.

公开(公告)号：US20140371427A1

公开(公告)日：2014-12-18

申请号：US14363735

申请日：2012-12-07

Applicant: AMGEN INC.

Inventor： Thomas M. Dillon ,  Yi-Te Chou ,  Yautyan Chen ,  Pavel Bondarenko ,  Jed J. Wiltzius ,  Diana Woehle

IPC: C07K1/18

CPC classification number: C07K1/18 ,  C07K16/00 ,  C07K16/06 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/53

Abstract: Methods for producing an IgG2 antibody preparation enriched for one of several IgG2 structural isoforms, differing by disulfide connectivity in the hinge region of the antibody, are disclosed.

Abstract translation: 公开了用于产生IgG2抗体制剂的方法，所述IgG2抗体制剂富含多种IgG2结构同种型之一，其不同于抗体铰链区中的二硫键连接。