公开(公告)号：US20230265145A1

公开(公告)日：2023-08-24

申请号：US18001913

申请日：2021-06-25

Applicant: AMGEN INC.

Inventor： Hailing HSU ,  Ian FOLTZ ,  Marissa MOCK ,  Victor Mitch LUNA ,  Ming ZHANG ,  Sharon Lynn WANNBERG ,  Gamze Ozlem CAMDERE TAPIA ,  Timothy Patrick RILEY

IPC: C07K14/54 ,  C07K16/28

CPC classification number: C07K14/5428 ,  C07K16/2803 ,  A61K38/00 ,  C07K2319/00

Abstract: Abstract: The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.

公开(公告)号：US20210079051A1

公开(公告)日：2021-03-18

申请号：US17094968

申请日：2020-11-11

Applicant: AMGEN INC.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. ZHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth William WALKER

IPC: C07K14/475

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20250066470A1

公开(公告)日：2025-02-27

申请号：US18435746

申请日：2024-02-07

Applicant: AMGEN INC.

Inventor： Sue J. SOHN ,  Marissa MOCK ,  Ian Nevin FOLTZ ,  Agnieszka KIELCZEWSKA ,  Kathy MANCHULENKO ,  Yannick BULLIARD ,  Xiaoshan MIN

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: Provided herein are TIGIT binding proteins, CD112R binding proteins, and combinations thereof. Also provided are compositions comprising TIGIT binding proteins and CD112R binding proteins, optionally further comprising PD-1 binding proteins. Related conjugates, fusion proteins, nucleic acids, vectors, host cells and kits are additionally provided. Further provided are pharmaceutical compositions comprising a TIGIT binding protein, CD112R binding protein, or a combination thereof, optionally, further comprising a PD-1 antigen binding protein, or a conjugate, fusion protein, nucleic acid, vector, or host cell, and a pharmaceutically acceptable carrier, diluent, or excipient, and methods of treating subjects in need thereof.

公开(公告)号：US20220017616A1

公开(公告)日：2022-01-20

申请号：US17375958

申请日：2021-07-14

Applicant: AMGEN INC.

Inventor： Sue J. SOHN ,  Marissa MOCK ,  Ian Nevin FOLTZ ,  Agnieszka KIELCZEWSKA ,  Kathy MANCHULENKO ,  Yannick BULLIARD ,  Xiaoshan MIN

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided herein are TIGIT binding proteins, CD112R binding proteins, and combinations thereof. Also provided are compositions comprising TIGIT binding proteins and CD112R binding proteins, optionally further comprising PD-1 binding proteins. Related conjugates, fusion proteins, nucleic acids, vectors, host cells and kits are additionally provided. Further provided are pharmaceutical compositions comprising a TIGIT binding protein, CD112R binding protein, or a combination thereof, optionally, further comprising a PD-1 antigen binding protein, or a conjugate, fusion protein, nucleic acid, vector, or host cell, and a pharmaceutically acceptable carrier, diluent, or excipient, and methods of treating subjects in need thereof.

公开(公告)号：US20160168213A1

公开(公告)日：2016-06-16

申请号：US14908459

申请日：2014-07-31

Applicant: AMGEN INC.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth WALKER

IPC: C07K14/475

CPC classification number: C07K14/475 ,  C07K2319/30

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract translation: 提供了包含GDF15的构建体及其突变体。 在各种实施方案中，包含GDF15及其突变体的构建体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。

公开(公告)号：US20240368236A1

公开(公告)日：2024-11-07

申请号：US18639202

申请日：2024-04-18

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth William WALKER

IPC: C07K14/475

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

公开(公告)号：US20230381276A1

公开(公告)日：2023-11-30

申请号：US18072959

申请日：2022-12-01

Applicant: AMGEN INC.

Inventor： Khaled M.K.Z. ALI ,  Neeraj Jagdish AGRAWAL ,  Gunasekaran KANNAN ,  Ian FOLTZ ,  Zhulun WANG ,  Darren BATES ,  Marissa MOCK ,  Shunsuke TAKENAKA

IPC: A61K38/20 ,  C12N15/63 ,  A61P35/00 ,  C07K16/28 ,  C07K14/54 ,  A61K47/68

CPC classification number: A61K38/20 ,  C12N15/63 ,  A61P35/00 ,  C07K16/283 ,  C07K14/54 ,  A61K47/6849 ,  A61K47/6813 ,  C12N2740/10041

Abstract: Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

公开(公告)号：US20180079790A1

公开(公告)日：2018-03-22

申请号：US15826442

申请日：2017-11-29

Applicant: Amgen Inc.

Inventor： Yumei XIONG ,  Yi ZHANG ,  Jackie Z. SHENG ,  Agnes Eva HAMBURGER ,  Murielle M. VENIANT-ELLISON ,  Grant SHIMAMOTO ,  Xiaoshan MIN ,  Zhulun WANG ,  Jie TANG ,  Gunasekaran KANNAN ,  Marissa MOCK ,  Kenneth William WALKER

IPC: C07K14/475

CPC classification number: C07K14/475 ,  C07K2319/30

Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.