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公开(公告)号：US09982054B2
公开(公告)日：2018-05-29
申请号：US15178652
申请日：2016-06-10
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US11965029B2
公开(公告)日：2024-04-23
申请号：US17339301
申请日：2021-06-04
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC classification number: C07K16/2866 , C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20190203209A1
公开(公告)日：2019-07-04
申请号：US16356807
申请日：2019-03-18
Applicant: Amgen Inc.
Inventor： Michael R. Comeau , David Fitzpatrick
IPC: C12N15/113 , C07K16/24 , A61K45/06 , A61K39/395 , A61K38/17 , A61K31/7088 , A61K38/20
CPC classification number: C12N15/1136 , A61K31/7088 , A61K38/1793 , A61K38/2046 , A61K39/3955 , A61K45/06 , C07K16/24 , C12N2310/11 , C12N2310/14
Abstract: The invention provides methods and compositions for reducing or preventing fibrosis in a subject suffering from a fibrotic disorder by administering a therapeutically effective amount of at least one antagonist to the cytokine thymic stromal lymphopoietin to the subject. In one embodiment, the methods and compositions further comprise administering at least one additional antagonist to an additional profibrotic cytokine, growth factor or chemokine.
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4.发明申请Antigen Binding Proteins Capable of Binding Thymic Stromal Lymphopoietin 审中-公开具有结合胸腺基质淋巴细胞生成素的抗原结合蛋白公开(公告)号：US20160152700A1
公开(公告)日：2016-06-02
申请号：US15014828
申请日：2016-02-03
Applicant: AMGEN INC.
Inventor： Michael R. Comeau , James F. Smothers , Bo-Rin P. Yoon , Christopher Mehlin
IPC: C07K16/24
CPC classification number: C07K16/24 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.
Abstract translation: 本公开提供了与抗人结合蛋白相关的组合物和方法，其结合人胸腺基质淋巴细胞生成素（TSLP），包括抗体。 在具体实施方案中，本公开提供完全人，人源化和嵌合抗TSLP抗体及其抗体的衍生物。 本公开进一步提供编码此类抗体和抗体片段及衍生物的核酸，以及制备和使用此类抗体的方法，包括治疗和预防TSLP相关炎症和纤维化病症的方法。
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公开(公告)号：US10287348B2
公开(公告)日：2019-05-14
申请号：US15014828
申请日：2016-02-03
Applicant: AMGEN INC.
Inventor： Michael R. Comeau , James F. Smothers , Bo-Rin P. Yoon , Christopher Mehlin
IPC: A61K39/00 , C07K16/24 , A61K39/395
Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.
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Patent Agency Ranking
公开(公告)号：US20140322238A1
公开(公告)日：2014-10-30
申请号：US14263534
申请日：2014-04-28
Applicant: Amgen Inc.
Inventor： Alison L. Budelsky , Michael R. Comeau , Joel E. Tocker
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K38/00 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/76
Abstract: The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.
Abstract translation: 本发明涉及白细胞介素-17配体和受体家族成员以及IL-17受体A和IL-17受体C形成具有生物活性的异聚受体复合物的发现。 公开了IL-17RA-IL-17RB异聚受体复合物的拮抗剂，以及各种使用方法。
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公开(公告)号：US20200071393A1
公开(公告)日：2020-03-05
申请号：US16406811
申请日：2019-05-08
Applicant: Amgen Inc.
Inventor： Michael R. Comeau , James F. Smothers , Bo-Rin P. Yoon , Christopher Mehlin
IPC: C07K16/24
Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-TSLP antibodies and derivatives of such antibodies. The disclosure further provides nucleic acids encoding such antibodies and antibody fragments and derivatives, and methods of making and using such antibodies including methods of treating and preventing TSLP-related inflammatory and fibrotic disorders.
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公开(公告)号：US10227414B2
公开(公告)日：2019-03-12
申请号：US15601868
申请日：2017-05-22
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
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公开(公告)号：US20160208004A1
公开(公告)日：2016-07-21
申请号：US14994108
申请日：2016-01-12
Applicant: AMGEN INC.
Inventor： Alison L. Budelsky , Michael R. Comeau , Joel E. Tocker
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K38/00 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/76
Abstract: The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA-IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.
Abstract translation: 本发明涉及白细胞介素-17配体和受体家族成员以及IL-17受体A和IL-17受体C形成具有生物活性的异聚受体复合物的发现。 公开了IL-17RA-IL-17RB异聚受体复合物的拮抗剂，以及各种使用方法。
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公开(公告)号：US09382318B2
公开(公告)日：2016-07-05
申请号：US13897096
申请日：2013-05-17
Applicant: Amgen Inc.
Inventor： Dirk E. Smith , Ian Foltz , Chadwick T. King , Ai Ching Lim , Rutilio Clark , Michael R. Comeau , Randal R. Ketchem , Donghui Shi , Xiaoshan Min , Zhulun Wang
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/11
Abstract: Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.
Abstract translation: 本文描述的是与抗原结合蛋白相关的组合物和方法，其结合人ST2，包括抗体。 在具体实施方案中，本公开提供完全人抗-ST2抗体及其衍生物及其变体。 还提供了编码这种抗体和抗体片段，变体和衍生物的核酸。 此外，提供制备和使用这些抗体的方法，包括治疗和预防自身免疫性和炎症性疾病的方法。
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