公开(公告)号：US20180267022A1

公开(公告)日：2018-09-20

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok LEE ,  Heung Soo BAEK ,  Yung Hyup JOO ,  Jeong Hwan KIM ,  Hong-Ju SHIN ,  Mi Young PARK ,  Song Seok SHIN

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N33/5014

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20180065922A1

公开(公告)日：2018-03-08

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Soo Jeong CHOI ,  Heung Soo BAEK ,  Chang Seok LEE ,  Jeong Hwan KIM ,  Yongjin KIM ,  Hong-Ju SHIN ,  Ho Sik RHO ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02

CPC classification number: C07C233/70 ,  A23L29/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  C07C231/12 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.