公开(公告)号：US20200016224A1

公开(公告)日：2020-01-16

申请号：US16471096

申请日：2017-11-21

Applicant: AMOREPACIFIC CORPORATION

Inventor： Su Kyung KIM ,  Jin Oh CHUNG ,  Wan Gi KIM ,  Jeong Kee KIM ,  Song Seok SHIN ,  Soon Mi SHIM ,  Da Yeon LEE ,  Sang Ryun YIM ,  Eun Hye CHOI

IPC: A61K36/82 ,  A61K36/25 ,  A61K36/8962 ,  A61K31/353 ,  A23L33/105

Abstract: The present invention relates to an enhancer for catechin uptake enhancer in enterocytes, wherein, by mixing a green tea extract containing catechin as an active ingredient, a Dendropanax morbifera extract, and an onion extract at a proper ratio, the stability in the digestive organ can be improved and, eventually, the catechin uptake in enterocytes can be enhanced.

公开(公告)号：US20190223486A1

公开(公告)日：2019-07-25

申请号：US16336797

申请日：2017-09-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Jin Oh CHUNG ,  Su Kyung KIM ,  Jeong Kee KIM ,  Wan Gi KIM ,  Song Seok SHIN ,  Soon Mi SHIM ,  Seon Bong LEE ,  Ji Hoon SONG ,  Seung Beom SEO

IPC: A23L33/10 ,  A61K31/357 ,  A61K31/352

Abstract: The present invention relates to a catechin absorption enhancer in small intestinal epithelial cells, and more particularly, to an enhancer for improving an absorption rate of catechin in small intestinal cells and a composition including the same. The composition including the catechin absorption enhancer in the small intestinal epithelial cells according to the invention can enhance the absorption rate of catechin in the small intestinal epithelial cells, which leads to improved bioavailability. Therefore, the present invention can be expected to improve an antioxidant effect, an anti-aging effect, a lipolytic effect, and a variety of other effects of the catechin.

公开(公告)号：US20180267022A1

公开(公告)日：2018-09-20

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok LEE ,  Heung Soo BAEK ,  Yung Hyup JOO ,  Jeong Hwan KIM ,  Hong-Ju SHIN ,  Mi Young PARK ,  Song Seok SHIN

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N33/5014

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20180065922A1

公开(公告)日：2018-03-08

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Soo Jeong CHOI ,  Heung Soo BAEK ,  Chang Seok LEE ,  Jeong Hwan KIM ,  Yongjin KIM ,  Hong-Ju SHIN ,  Ho Sik RHO ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02

CPC classification number: C07C233/70 ,  A23L29/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  C07C231/12 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

公开(公告)号：US20170283347A1

公开(公告)日：2017-10-05

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Song Seok SHIN ,  Byoung Young WOO ,  Heung Soo BAEK ,  Yong Deog HONG ,  Hong-Ju SHIN ,  Yeon Su JEONG ,  Jon Hwan LEE

IPC: C07C13/615 ,  C07C233/57 ,  C07C15/04

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US20170007535A1

公开(公告)日：2017-01-12

申请号：US15121874

申请日：2015-02-27

Applicant: AMOREPACIFIC CORPORATION

Inventor： Se Jin YOO ,  Seon Su HAN ,  Hyang Tae CHOI ,  Song Seok SHIN

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/82 ,  A61K2800/74 ,  A61Q19/00 ,  A61Q19/007

Abstract: When a catechin-free tea water according to the present invention is contained in a cosmetic or pharmaceutical composition, enzymes are inactivated and catechin contained in tea leaves is removed by steaming unprocessed raw tea leaves, thereby preventing the oxidation of tea water. Therefore, a composition containing the tea water according to the present invention can prevent offensive odor generation or discoloration of the composition, thereby enabling the stable use thereof in various industrial fields such as food, cosmetics and medicine. In addition, plenty of skin helpful ingredients, contained in raw tea leaves, can be contained, and thus excellent skin barrier function recovery or skin moisturization effects can be provided.

Abstract translation: 当化妆品或药物组合物中含有本发明的不含儿茶素的茶水时，通过蒸煮未处理的生茶叶来除去茶叶中含有的儿茶素，从而防止茶水的氧化。 因此，含有本发明的茶水的组合物可以防止组合物的异味产生或变色，从而能够在各种工业领域如食品，化妆品和医药中稳定地使用。 此外，可以含有大量含有生皮茶叶的皮肤有益成分，因此可以提供优异的皮肤屏障功能恢复或皮肤保湿效果。

公开(公告)号：US20160324824A1

公开(公告)日：2016-11-10

申请号：US15107955

申请日：2015-01-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik RHO ,  Heung Soo BAEK ,  Yu Jung KIM ,  Song Seok SHIN ,  John Hwan LEE

IPC: A61K31/357 ,  A61K8/49 ,  A61Q19/00 ,  A61K31/36

CPC classification number: A61K31/357 ,  A61K8/498 ,  A61K31/36 ,  A61K2800/74 ,  A61K2800/91 ,  A61K2800/92 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.

Abstract translation: 本发明涉及含有羟基吡喃酮衍生物化合物作为促进脂肪细胞分化的活性成分的化妆品组合物。 根据本发明的组合物具有促进脂肪细胞分化的作用，从而允许脂肪细胞在皮肤层中分化，从而增加皮肤体积或弹性。 因此，本发明的组合物可以各种用作本领域的化妆品组合物或药物组合物，例如皮肤损伤。

公开(公告)号：US20170312230A1

公开(公告)日：2017-11-02

申请号：US15518428

申请日：2015-10-21

Applicant: Amorepacific Corporation

Inventor： Heung Soo BAEK ,  Byeong Yung WOO ,  Se Jin YOO ,  Yung Hyup JOO ,  Song Seok SHIN ,  Mi Hyun OH ,  John Hwan LEE ,  Seo Young KIM

IPC: A61K31/047 ,  A61Q19/10 ,  A61K8/34

CPC classification number: A61K31/047 ,  A61K8/30 ,  A61K8/34 ,  A61Q19/10

Abstract: The present invention relates to a composition which can effectively control bacteria by containing meso-2,3-butanediol, which is an isomer of 2,3-butane diol, and has excellent antiseptic power even without containing a chemical antiseptic agent.

公开(公告)号：US20160106864A1

公开(公告)日：2016-04-21

申请号：US14883327

申请日：2015-10-14

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyung Jun LIM ,  Nok Hyun PARK ,  Yuri CHOI ,  Il-Hong BAE ,  Myeong Jin GOH ,  Jae Won YOU ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: A61K47/48 ,  A61K8/64 ,  A61K9/107 ,  A61Q19/00 ,  A61K9/127 ,  A61K8/06 ,  A61K9/00 ,  A61K8/14

CPC classification number: A61K9/1075 ,  A61K8/0241 ,  A61K8/042 ,  A61K8/062 ,  A61K8/14 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/1271 ,  A61K9/1275 ,  A61K47/62 ,  A61K47/6911 ,  A61K2800/654 ,  A61Q1/02 ,  A61Q19/00 ,  A61Q19/10

Abstract: The present disclosure relates to a drug delivery carrier containing a lipid structure or a polymer particle which is covalently bonded to a cell-penetrating AP-GRR peptide (SEQ ID NO 1) or is modified with the peptide chain containing the peptide. The present disclosure also relates to a composition containing the drug delivery carrier and a physiologically active ingredient encapsulated in the carrier. The drug delivery carrier of the present disclosure can effectively deliver macromolecules that are difficult to be delivered into cells, thereby improving the bioavailability of the macromolecules.

Abstract translation: 本公开内容涉及含有脂质结构或聚合物颗粒的药物递送载体，其共价结合到细胞穿透性AP-GRR肽（SEQ ID NO 1）或用含有肽的肽链进行修饰。 本公开还涉及包含药物递送载体和包封在载体中的生理活性成分的组合物。 本公开的药物递送载体可以有效地递送难以递送到细胞中的大分子，从而提高大分子的生物利用度。

公开(公告)号：US20140011881A1

公开(公告)日：2014-01-09

申请号：US14022789

申请日：2013-09-10

Applicant: Amorepacific Corporation

Inventor： Song Seok SHIN ,  Jin Kwan KIM ,  Sun-Young KIM ,  Ki-Wha LEE ,  Byoung young WOO ,  Joo-Hyun MOH ,  Yeon Su JEONG ,  Kyung Min LIM ,  Jin Kyu CHOI ,  Hyun-Ju KOH ,  Young-Ho PARK

IPC: C07C311/08

CPC classification number: C07C311/08 ,  C07C2601/14 ,  C07D295/145

Abstract: This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same.The present disclosure provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Abstract translation: 本公开涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanilloid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本公开提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。