公开(公告)号：US20180179146A1

公开(公告)日：2018-06-28

申请号：US15736406

申请日：2016-06-03

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Yong Jin KIM ,  Hong-Ju SHIN ,  John Hwan LEE

IPC: C07C231/02

Abstract: The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

公开(公告)号：US20170283347A1

公开(公告)日：2017-10-05

申请号：US15506972

申请日：2015-08-24

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Song Seok SHIN ,  Byoung Young WOO ,  Heung Soo BAEK ,  Yong Deog HONG ,  Hong-Ju SHIN ,  Yeon Su JEONG ,  Jon Hwan LEE

IPC: C07C13/615 ,  C07C233/57 ,  C07C15/04

Abstract: Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

公开(公告)号：US20150306024A1

公开(公告)日：2015-10-29

申请号：US14794440

申请日：2015-07-08

Applicant: Amorepacific Corporation

Inventor： Jeong-Hwan KIM ,  Won Seok PARK ,  Hyun Ju KOH ,  Hong-Ju SHIN ,  Do-Hoon KIM ,  Jong Hee PARK ,  Chang-Geun YI ,  Hyoung Jun KIM ,  Jung A SEO

IPC: A61K8/97 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A61K36/254 ,  A61K36/481 ,  A61K36/484 ,  A61K36/708 ,  A61K36/73 ,  A61K36/756 ,  A61K36/78 ,  A61Q19/00 ,  A61Q19/02

Abstract: Disclosed is a composition containing an active ingredient or ingredients comprising an extract or extracts of one or more constituents selected from the group consisting of Astragalus membranaceus, Saururus chinensis, Glycyrrhizae radix, rose, rhubarb, Acanthopanax senticosus and cortex Phellodendri. The composition is efficacious in suppressing acneiform pigment deposition and/or pitted scars, and can be used to advantage in various ways in the fields of cosmetics, foods and drugs.

Abstract translation: 本发明公开了含有活性成分或成分的组合物，其含有选自黄芪，中华黄芪，甘草，玫瑰，大黄，刺五加和皮质黄酮的一种或多种成分的提取物或提取物。 该组合物有效地抑制粉刺沉积和/或凹痕的疤痕，并且可以在化妆品，食品和药物领域以各种方式有利地使用。

公开(公告)号：US20180116933A1

公开(公告)日：2018-05-03

申请号：US15561428

申请日：2016-03-29

Applicant: Amorepacific Corporation

Inventor： Yung Hyup JOO ,  Heung Soo BAEK ,  Jeong Ah HWANG ,  Hae Kwang LEE ,  Yongjin KIM ,  Hong-Ju SHIN ,  Jon Hwan LEE

IPC: A61K8/42 ,  A61Q19/08 ,  A61K31/166 ,  A23L33/00 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L2/52

CPC classification number: A61K8/42 ,  A23L2/52 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23L33/30 ,  A23V2002/00 ,  A61K8/30 ,  A61K8/34 ,  A61K31/166 ,  A61Q19/08

Abstract: 5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present specification can exhibit excellent anti-oxidative and anti-aging effects while having no toxicity. For example, the compound exhibits excellent anti-oxidative and anti-aging effects by scavenging free radicals or inhibiting MMP-1 expression.

公开(公告)号：US20180267022A1

公开(公告)日：2018-09-20

申请号：US15542263

申请日：2016-02-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Chang Seok LEE ,  Heung Soo BAEK ,  Yung Hyup JOO ,  Jeong Hwan KIM ,  Hong-Ju SHIN ,  Mi Young PARK ,  Song Seok SHIN

IPC: G01N33/50

CPC classification number: G01N33/5044 ,  G01N33/5014

Abstract: In one aspect of the present specification, provided is a method for predicting a side effect of a whitening ingredient, the method comprising measuring at least one of i) the increase in toxicity according to long-term use of a whitening ingredient, ii) the difference between a concentration having whitening effect and a concentration having cell toxicity, and iii) the increase in sensitivity to the whitening ingredient according to ultraviolet pretreatment. In addition, the method has an effect of effectively predicting whether a side effect will occur if the whitening ingredient is used for a long time.

公开(公告)号：US20180065922A1

公开(公告)日：2018-03-08

申请号：US15561585

申请日：2016-03-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yung Hyup JOO ,  Soo Jeong CHOI ,  Heung Soo BAEK ,  Chang Seok LEE ,  Jeong Hwan KIM ,  Yongjin KIM ,  Hong-Ju SHIN ,  Ho Sik RHO ,  Song Seok SHIN ,  Jon Hwan LEE

IPC: C07C233/70 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02

CPC classification number: C07C233/70 ,  A23L29/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/02 ,  C07C231/12 ,  C07C235/48

Abstract: Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.