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    ANTI-Aß GLOBULOMER 4D10 ANTIBODIES
    1.
    发明申请
    ANTI-Aß GLOBULOMER 4D10 ANTIBODIES 审中-公开
    ANTI-AßGLOBULOMER 4D10抗体

    公开(公告)号：US20170022269A1

    公开(公告)日：2017-01-26

    申请号：US15290699

    申请日：2016-10-11

    Applicant: ABBVIE INC. ,  ABBVIE DEUTSCHLAND GMBH & CO. KG

    Inventor： Stefan Barghorn ,  Heinz Hillen ,  Boris Labkovsky ,  Andreas R. Striebinger ,  Patrick Keller ,  Ulrich Ebert

    IPC: C07K16/18 ,  G01N33/68

    Abstract: Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

    Abstract translation: 本发明涉及对Aβ（20-42）球聚体具有结合亲和力的抗Aβ球聚体抗体，其大于抗体对Aβ（1-42）球聚体的结合亲和力，其抗原结合部分，产生所述 抗体，编码所述抗体的核酸，包含所述核酸的载体，包含所述载体的宿主细胞，产生所述抗体的方法，包含所述抗体的组合物，所述抗体的治疗和诊断用途以及与阿尔茨海默病和其它淀粉样变性有关的相应方法。

    Anti-Aβ globulomer 7C6 antibodies
    2.
    发明授权
    Anti-Aβ globulomer 7C6 antibodies 有权
    抗Aβ球寡糖7C6抗体

    公开(公告)号：US09540432B2

    公开(公告)日：2017-01-10

    申请号：US13893780

    申请日：2013-05-14

    Applicant: ABBVIE INC. ,  ABBVIE DEUTSCHLAND GMBH & CO. KG

    Inventor： Stefan Barghorn ,  Heinz Hillen ,  Boris Labkovsky ,  Andreas R. Striebinger ,  Patrick Keller ,  Ulrich Ebert

    IPC: C07K16/00 ,  C07K16/18 ,  C07K14/47 ,  A61K38/00

    CPC classification number: C07K16/18 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4711 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/387

    Abstract: Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

    Abstract translation: 本发明涉及对Aβ（20-42）球聚体具有结合亲和力的抗Aβ球聚体抗体，其大于抗体对Aβ（1-42）球聚体的结合亲和力，其抗原结合部分，产生所述 抗体，编码所述抗体的核酸，包含所述核酸的载体，包含所述载体的宿主细胞，产生所述抗体的方法，包含所述抗体的组合物，所述抗体的治疗和诊断用途以及与阿尔茨海默病和其它淀粉样变性有关的相应方法。

    Anti-Aβ globulomer 4D10 antibodies
    5.
    发明授权
    Anti-Aβ globulomer 4D10 antibodies 有权

    公开(公告)号：US10538581B2

    公开(公告)日：2020-01-21

    申请号：US15290699

    申请日：2016-10-11

    Applicant: ABBVIE INC. ,  ABBVIE DEUTSCHLAND GMBH & CO. KG

    Inventor： Stefan Barghorn ,  Heinz Hillen ,  Boris Labkovsky ,  Andreas R. Striebinger ,  Patrick Keller ,  Ulrich Ebert

    IPC: C07K16/00 ,  C07K16/18 ,  C07K14/47 ,  G01N33/68 ,  A61K38/00 ,  A61K39/00

    Abstract: Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

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